Objective To retrospectively analyze the characteristics of viral antibodies related to nervous system infections in patients with cognitive impairment,evaluate their relationship with cognitive impairment,and explore the relationship between viral infections and the occurrence and development of cognitive impair-ment.Methods A total of 170 mild cognitive impairment patients who visited Beijing Tiantan Hospital,Cap-ital Medical University from June 2019 to June 2023 were selected as the mild cognitive impairment group,208 cognitive impairment patients were selected as the cognitive impairment group,143 dementia patients were se-lected as the dementia group,and 146 age-matched and gender-matched non infectious and non inflammatory disease controls during the same period in the hospital were selected as the control group.The levels of virus antibodies related to nervous system infections in the serum and cerebrospinal fluid of patients were detected,the detection rate and levels of antibodies were compared,and the infection burden was calculated.The cogni-tive function of all patients was evaluated and the relationship between infection burden and the degree of cog-nitive dysfunction was analyzed.Results The detection rate and antibody level of herpes simplex virus(HSV)1 IgG in the serum of three groups of patients with cognitive impairment were significantly higher than those in the control group(P＜0.05).The detection rate of HSV(1+2)IgM in the serum of three groups of pa-tients with cognitive impairment was higher than that in the control group(P＜0.05),but there was no sta-tistically significant difference between the mild cognitive impairment group,cognitive impairment group,and dementia group(P＞0.05).The serum infection load of three groups of patients with cognitive impairment was higher than that of the control group(P＜0.05),and the higher the infection load,the more severe the cognitive impairment.Conclusion Viral infection is an important influencing factor of cognitive impairment diseases,and HSV infection may be a promoting factor of cognitive dysfunction.

Objective To analyze the clinicopathological features and immunohistochemical expression of meningiomas in the Tibetan population in Tibet,and improve the understanding of meningiomas. Methods The clinical and pathological data of all the meningiomas diagnosed by pathology in Tibet Autonomous Region People's Hospital from April 2013 to March 2021 were analyzed retrospectively.All the cases underwent immunohistochemical staining of trimethylation of lysine 27 on histone H3 (H3K27me3),mucin 4 (MUC4),somatostatin receptor 2 (SSTR2),progesterone receptor,epithelial membrane antigen,glial fibrillary acidic protein,vimentin,S-100,P53,and Ki-67.The histopathological features and the staining results were observed under a light microscope. Results A total of 116 cases of meningiomas were included in this study,with the male-to-female ratio of 1.0∶2.6 and the age of 4-73 years.The main clinical symptom was headache.The imaging examination showed that 114 cases had single lesions and 2 cases had multiple lesions.The tumors were located in the cranium (108 cases) and spinal canal (8 cases).The maximum diameter of the tumors ranged from 0.3 cm to 10.0 cm,with a mean of (5.7±2.2) cm.In terms of microscopic grading and histological types,the 116 cases included 111 cases of WHO grade Ⅰ (including 53 cases of fibrous type,20 cases of meningothelial type,24 cases of transitional type,10 cases of psammomatous type,etc.),4 cases of WHO grade Ⅱ (3 cases of atypical type and 1 case of clear cell type),and 1 case of WHO grade Ⅲ (papillary type).The immunohistochemical staining showed H3K27me3 expression absent in 9 cases (9/116,7.8%),MUC4 positive in 64 cases (64/116,55.2%),SSTR2 positive in 101 cases (101/116,87.1%).Eighty cases had follow-up results,among which 71 cases had no recurrence,while 9 cases recurred. Conclusions Meningioma is the most common tumor in the central nervous system in the pathological file of Tibet.It mainly attacks the middle-aged female patients,occupying the parasagittal sinus,falx,and convex surface of the brain.Fibrous meningioma of WHO grade Ⅰ is common,while the meningiomas of WHO grades Ⅱ and Ⅲ are rare.The expression degree of MUC4 is higher in meningothelial and transitional meningiomas but lower in fibrous meningiomas.There may be no correlation between the absence of H3K27me3 expression and prognosis.
Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Histones ; Humans ; Male ; Meningeal Neoplasms/diagnosis* ; Meningioma/diagnosis* ; Middle Aged ; Retrospective Studies ; Tibet ; Young Adult