BACKGROUND: The association of systemic inflammatory response index (SIRI) with prognosis of coronary artery disease (CAD) patients has never been investigated in a large sample with long-term follow-up. This study aimed to explore the association of SIRI with all-cause and cause-specific mortality in a nationally representative sample of CAD patients from United States. METHODS: A total of 3386 participants with CAD from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were included in this study. Cox proportional hazards model, restricted cubic spline (RCS), and receiver operating characteristic curve (ROC) were performed to investigate the association of SIRI with all-cause and cause-specific mortality. Piece-wise linear regression and sensitivity analyses were also performed. RESULTS: During a median follow-up of 7.7 years, 1454 all-cause mortality occurred. After adjusting for confounding factors, higher lnSIRI was significantly associated with higher risk of all-cause (HR = 1.16, 95% CI: 1.09-1.23) and CVD mortality (HR = 1.17, 95% CI: 1.05-1.30) but not cancer mortality (HR = 1.17, 95% CI: 0.99-1.38). The associations of SIRI with all-cause and CVD mortality were detected as J-shaped with threshold values of 1.05935 and 1.122946 for SIRI, respectively. ROC curves showed that lnSIRI had robust predictive effect both in short and long terms. CONCLUSIONS SIRI was independently associated with all-cause and CVD mortality, and the dose-response relationship was J-shaped. SIRI might serve as a valid predictor for all-cause and CVD mortality both in the short and long terms.

OBJECTIVETo investigate and analyses feasibility and therapeutic effect of pedicle of vertebral arch drilling in the treatment of old vertebrae compression fracture patients suffering back pain.

METHODSFrom May 2004 to December 2011, 19 patients with back pain caused of old vertebrae compression fracture were treated by vertebral body decompression with drilling. There were 13 males and 6 females with with an average age of 61 years old ranging from 44 to 78 years. The course of disease was 3 months to 8 years (means 2.5 years). Among them,6 cases were chest-back pain and 13 were lumbodorsal pain. The thoracic vertebrae fracture involved in 9 segments, lumbar vertebrae fracture involved in 18 segments, vertebral height lose

RESULTSNineteen patients were followed up from 6 months to 3 years. The symtoms were not recurrened. The VAS score was 5.7+/-0.3 preoperative and 2.3+/-0.2 postoperative. The pain relieved obviously in 4 patients and mainly in 5 patients at 24 hours after operation, and the pain relieved obviously in 10 patients and mainly in 9 patients at 48 hours after operation.

CONCLUSIONVertebral drill decompression is an effective method for the treatment of old osteoporotic compression fractures with minimally invasive and low complication.

Adult ; Aged ; Back Pain ; surgery ; Decompression, Surgical ; methods ; Female ; Fractures, Compression ; surgery ; Humans ; Male ; Middle Aged ; Spinal Fractures ; surgery

Adult ; Aged ; Aged, 80 and over ; Decompression, Surgical ; Female ; Fractures, Bone ; complications ; surgery ; Humans ; Leg Injuries ; complications ; surgery ; Male ; Middle Aged