A 68-year-old female patient with rheumatic heart disease and auricular fibrillation received warfarin (10.5 mg per week, totally 6 weeks;then 12 mg per week, totally 3 weeks).The international nomalized ratio (INR) was monitored regularly.Her INR was steady and reached the standard during the medication.She took Zhisou Lixiao Wan 12 g daily by herself because of cough on the 10th week.Four days later she found multiple ecchymosis at her front of right leg and the INR was 6.46.Warfarin was withdrawn while Zhisou Lixiao Wan was continued.Three days later, the ecchymosis was absorbed obviously and the INR decreased to 2.96.Zhisou Lixiao Wan was stopped and warfarin was taken by 12 mg weekly.Five days later, her INR was 2.24 and the ecchymosis disappeared completely.

A 68-year-old female patient with rheumatic heart disease and auricular fibrillation received warfarin (10.5 mg per week, totally 6 weeks;then 12 mg per week, totally 3 weeks).The international nomalized ratio (INR) was monitored regularly.Her INR was steady and reached the standard during the medication.She took Zhisou Lixiao Wan 12 g daily by herself because of cough on the 10th week.Four days later she found multiple ecchymosis at her front of right leg and the INR was 6.46.Warfarin was withdrawn while Zhisou Lixiao Wan was continued.Three days later, the ecchymosis was absorbed obviously and the INR decreased to 2.96.Zhisou Lixiao Wan was stopped and warfarin was taken by 12 mg weekly.Five days later, her INR was 2.24 and the ecchymosis disappeared completely.