Patients with inflammatory bowel disease (IBD) require long-term pharmacotherapy. Due to the wide variety of clinically available drugs, medication safety has become increasingly concerning. As an indispensable component of pharmaceutical formulations, drug excipients may induce various adverse reactions, including rash, allergic responses, and gastrointestinal discomfort, and may even lead to severe organic injury. However, they are often overlooked in clinical practice. Therefore, identifying and managing excipient-related adverse reactions is crucial for ensuring medication safety. To address this issue, this article systematically reviews common excipients in IBD therapeutics, the underlying mechanisms of excipient-induced adverse reactions, and corresponding management strategies, aiming to enhance clinicians' awareness of excipient-related issues, improve their ability to recognize and manage such reactions, and ultimately ensure patient safety.

BackgroundGraduate students frequently face life events， many of which may adversely affect their mental well-being. However， the interaction between life events and the development of depression， anxiety， and somatic symptoms remains unclear. ObjectiveTo explore the relationship between life events and the development of depressive， anxiety and somatic symptoms in graduate students， thereby informing prevention strategies for these conditions. MethodsA sample of 6 722 newly enrolled graduate students at a comprehensive university in Southwest China from September to November 2018 was selected. The assessment was conducted using the Adolescent Self-rating Life Events Checklist （ASLEC）， the 7-item Generalized Anxiety Disorder scale-7 item （GAD-7）， the Patient Health Questionnaire Depression Scale-9 item （PHQ-9）， and the Patient Health Questionnaire-15 （PHQ-15）. Network analysis was implemented by using the bootnet and qgraph packages in the R software （version 4.2.3）， with centrality indices calculated to identify core and bridge symptoms within the network. ResultsThe study encompassed a total of 6 171 graduate students， representing 91.80% of the target population. The prevalence rates of anxiety， depressive， and somatic symptoms among graduate students were 12.59% （777/6 171）， 16.63% （1 026/6 171）， and 27.66% （1 707/6 171）， respectively. Network analysis revealed that 'academic stress' was the core symptom with the highest strength and expected influence （both values=1.207）， while 'feeling down， depressed， or hopeless' was the bridge symptom with the highest bridge strength and bridge expected influence （both values=0.454）. There was no significant difference in global network strength and edge weight between women and men （P>0.05）. ConclusionAcademic stress， emerging as the core symptom， assumes a dominant position within the symptom network and exhibits strong interactions with other negative affective states. There was no gender difference in the network structure.

BackgroundPrevious studies have identified a close relationship among psychological neglect and abuse， negative affect， different stages of adolescence， and suicidal ideation. However， the mechanisms underlying the impact of psychological abuse and neglect on suicidal ideation among left-behind adolescents remain unclear， and this field of research is still in its relative infancy. ObjectiveTo explore the relationship between psychological neglect/abuse and suicidal ideation among left-behind adolescents， as well as the mediating role of negative affect and the moderating effect of different stages of adolescence， so as to provide insights for preventing and intervening suicidal ideation in this population. MethodsFrom November 2021 to May 2022， a cluster random sampling technique was utilized to select 2 309 left-behind adolescents in western China. Assessments were conducted using the Child Psychological Abuse and Neglect Scale （CPANS）， the Positive and Negative Suicide Ideation （PANSI） and the Positive and Negative Affect Schedule for Children （PANAS-C）. Spearman correlation coefficients were calculated across all samples， and Process 4.1 was employed to test the mediating role of negative affect and the moderating role of different stages of adolescence in the pathway linking psychological abuse/neglect to suicidal ideation. ResultsA total of 2 119 left-behind adolescents （mean age： 14.94±1.20 years） completed the study， with males comprising 51.34% （1 088/2 119） and females 48.66% （1 031/2 119）.Among left-behind adolescents， scores on CPANS psychological neglect subscale showed positive correlations with both psychological abuse subscale scores and PANAS-C negative affect subscale scores （r=0.446， 0.496， P<0.01）. Additionally， CPANS psychological neglect and psychological abuse subscale scores were also positively correlated with PANSI scores （r=0.487， 0.508， P<0.01）. Furthermore， PANAS-C negative affect subscale scores demonstrated a positive correlation with PANSI scores （r=0.499， P<0.01）. Negative affect partially mediated the relationship between psychological abuse/psychological neglect and suicidal ideation， with effect sizes of 0.166 （95% CI： 0.141~0.191） and 0.131 （95% CI： 0.112~0.152）. Different stages of adolescence moderated the latter part （negative emotion → suicidal ideation） of the indirect mediation path from psychological neglect to suicidal ideation through negative affect （β=-0.066， P<0.01）. ConclusionBoth psychological neglect and psychological abuse may influence suicidal ideation among left-behind adolescents via negative affect. Moreover， different stages of adolescence may moderate the indirect path from psychological neglect to suicide ideation through negative affect.

To analyze potential adverse drug events(ADEs) associated with ustekinumab and upadacitinib in the treatment of inflammatory bowel disease(IBD) based on an international authoritative database, thereby providing evidence for clinical medication safety.

Objective Based on the original text of Synopsis of Golden Chamber,we summarized and analyzed the pulse manifestation,characteristics of disease location,nature and syndrome,and main diseases of the stringed pulse in order to provide a systematic reference for its clinical application.Methods The sentences containing"stringed pulse"were sorted out according to the order of chapters in Synopsis of Golden Chamber firstly.Then the characteristics of pulse manifestation and pathogenesis were summarized.Finally,its main diseases and clinical significance were analyzed.Results This study summarized characteristics of the stringed pulse manifestation in Synopsis of Golden Chamber:the pulse flexibility is as tight as a bow string,the pulse shapes are straight up and down.And characteristics of the string pulse pathogenesis:the disease location is mainly interior,located in the chest,abdomen,liver and ribs;the nature of disease mainly tends to cold syndrome and excess syndrome;the main symptom is pain.There are seven main diseases related to string pulse:disease with symptoms such as convulsion,opisthotonos,trismus;malaria;stagnation of qi in chest;cold abdominal colic;Fluid retention disease;gastric disorder causing nausea and spasm.Conclusion The characteristics and main diseases of the string pulse reflected in the Synopsis of the Golden Chamber embody the thinking mode of diagnosis and treatment based on disease,syndrome and pulse,which has had a profound impact on the theory of diagnosis and treatment in later generations.

Objective:This study aims to analyze the clinical data of elderly patients who experienced respiratory failure after undergoing thoracoscopic-assisted radical lung cancer surgery.The objectives are to identify the risk factors associated with respiratory failure and to investigate the clinical significance of independent risk factors for the early prediction of respiratory failure in this patient population.Methods:A total of 42 elderly patients who developed respiratory failure following thoracoscopic-assisted radical lung cancer surgery at our hospital between January 1, 2021, and December 31, 2023, were continuously collected to form the observation group.Concurrently, a control group was established by randomly selecting elderly lung cancer patients who did not experience respiratory failure during the same period, in a 1: 1 ratio.Clinical data were collected from both groups, and logistic univariate and multivariate analyses were conducted.A receiver operating characteristic(ROC)curve was employed to evaluate the area under the curve(AUC), as well as the sensitivity and specificity of independent risk factors and their combinations.Results:The history of diabetes, PCT levels, and surgical day intake have been identified as independent risk factors for respiratory failure.Multivariate analysis revealed that a history of diabetes( OR: 1.29, 95% CI: 0.89-1.69; P=0.012), PCT( OR: 1.75, 95% CI: 1.51-2.38; P=0.005), and surgical day intake( OR: 1.42, 95% CI: 1.14-1.76; P<0.001)were significantly associated with the occurrence of postoperative respiratory failure.The area under the curve(AUC)values for predicting respiratory failure were 0.679, 0.679, and 0.740, respectively.The sensitivity and specificity for a history of diabetes were 41.2% and 87.1%; for PCT, 64.7% and 64.5%; and for surgical day intake, 70.6% and 74.2%.Notably, a combined model incorporating these three indicators produced an AUC of 0.918, with a sensitivity of 94.1% and a specificity of 80.6%. Conclusions:Following thoracoscopic-assisted radical lung cancer surgery, elderly patients with a history of diabetes, elevated PCT levels, and a daily fluid intake exceeding 2000 ml on the day of surgery demonstrate significant clinical value for the early detection of respiratory failure.

Objective Based on the original text of Synopsis of Golden Chamber,we summarized and analyzed the pulse manifestation,characteristics of disease location,nature and syndrome,and main diseases of the stringed pulse in order to provide a systematic reference for its clinical application.Methods The sentences containing"stringed pulse"were sorted out according to the order of chapters in Synopsis of Golden Chamber firstly.Then the characteristics of pulse manifestation and pathogenesis were summarized.Finally,its main diseases and clinical significance were analyzed.Results This study summarized characteristics of the stringed pulse manifestation in Synopsis of Golden Chamber:the pulse flexibility is as tight as a bow string,the pulse shapes are straight up and down.And characteristics of the string pulse pathogenesis:the disease location is mainly interior,located in the chest,abdomen,liver and ribs;the nature of disease mainly tends to cold syndrome and excess syndrome;the main symptom is pain.There are seven main diseases related to string pulse:disease with symptoms such as convulsion,opisthotonos,trismus;malaria;stagnation of qi in chest;cold abdominal colic;Fluid retention disease;gastric disorder causing nausea and spasm.Conclusion The characteristics and main diseases of the string pulse reflected in the Synopsis of the Golden Chamber embody the thinking mode of diagnosis and treatment based on disease,syndrome and pulse,which has had a profound impact on the theory of diagnosis and treatment in later generations.

Objective:This study aims to analyze the clinical data of elderly patients who experienced respiratory failure after undergoing thoracoscopic-assisted radical lung cancer surgery.The objectives are to identify the risk factors associated with respiratory failure and to investigate the clinical significance of independent risk factors for the early prediction of respiratory failure in this patient population.Methods:A total of 42 elderly patients who developed respiratory failure following thoracoscopic-assisted radical lung cancer surgery at our hospital between January 1, 2021, and December 31, 2023, were continuously collected to form the observation group.Concurrently, a control group was established by randomly selecting elderly lung cancer patients who did not experience respiratory failure during the same period, in a 1: 1 ratio.Clinical data were collected from both groups, and logistic univariate and multivariate analyses were conducted.A receiver operating characteristic(ROC)curve was employed to evaluate the area under the curve(AUC), as well as the sensitivity and specificity of independent risk factors and their combinations.Results:The history of diabetes, PCT levels, and surgical day intake have been identified as independent risk factors for respiratory failure.Multivariate analysis revealed that a history of diabetes( OR: 1.29, 95% CI: 0.89-1.69; P=0.012), PCT( OR: 1.75, 95% CI: 1.51-2.38; P=0.005), and surgical day intake( OR: 1.42, 95% CI: 1.14-1.76; P<0.001)were significantly associated with the occurrence of postoperative respiratory failure.The area under the curve(AUC)values for predicting respiratory failure were 0.679, 0.679, and 0.740, respectively.The sensitivity and specificity for a history of diabetes were 41.2% and 87.1%; for PCT, 64.7% and 64.5%; and for surgical day intake, 70.6% and 74.2%.Notably, a combined model incorporating these three indicators produced an AUC of 0.918, with a sensitivity of 94.1% and a specificity of 80.6%. Conclusions:Following thoracoscopic-assisted radical lung cancer surgery, elderly patients with a history of diabetes, elevated PCT levels, and a daily fluid intake exceeding 2000 ml on the day of surgery demonstrate significant clinical value for the early detection of respiratory failure.

Objective:To investigate the effect of early gradual diet on reducing delirium in elderly patients with hip arthroplasty.Methods:From January 2018 to January 2020, 74 cases of hip arthroplasty patients aged over 65 years old who were treated in the Third Affiliated Hospital of Sun Yat-sen University were selected as the observation objects. They were randomly divided into experimental group and control group with 37 cases in each group. The experimental group was given early gradual diet on the basis of routine postoperative care, while the control group was given routine postoperative diet on the basis of routine postoperative care. The incidence of postoperative delirium, Pittsburgh Sleep Quality Index (PSQI), patient satisfaction rate, average hospitalization days and average hospitalization expenses were used to evaluate the effect of early gradual diet on reducing delirium in elderly patients with hip arthroplasty.Results:The incidence of delirium in the experimental group was 2.70% (1/37) and 16.22% (6/37) in the control group, the difference was statistically significant ( χ2 value was 3.945, P<0.05); the hospitalization days of the experimental group were (10.68±5.13) d, (13.62±7.19) d in the control group. The difference of hospitalization days was statistically significant ( t value was 2.877, P<0.01). The incidence of difficulty in falling asleep and the satisfaction rate of the experimental group were 8.11% (3/37) and 94.59% (35/37) respectively, and those in the control group were 29.73% (11/37) and 78.38% (29/37) respectively, and the differences were statistically significant ( χ2 value was 5.638, 4.163, P<0.05). Conclusions:Early gradual diet after operation can reduce the incidence of delirium in elderly patients with hip arthroplasty, shorten the average hospitalization days, reduce the incidence of difficulty in falling asleep, improve patients' satisfaction, and help patients to pass through the perioperative period more safely and comfortably.

Objective: To investigated the effect of long-term low-concentration mixed benzene exposure on peripheral blood of male workers. Methods: A case-control study was conducted to select 452 male workers exposed to mixed benzene (benzene, toluene, xylene) for five consecutive years from January 2012 to December 2016 in an automobile manufacturer as case group, and 438 male administrative and logistic managers who underwent physical examination during the same period as control group. The peripheral blood of the two groups was tested and compared, and the occupational hazards in the workplace were detected. Results: There were low dose exposure to mixed benzene in the enterprise, but the test results met the occupational exposure limit requirements. During the five years from 2010 to 2016, between the two groups of workers, the mean values of WBC, NEUT, RBC and Hb were statistically different (P<0.05). There was no statistical difference (P>0.05) in the mean value of PLT. The abnormal rate of main peripheral blood indexes in the control group was higher than that in the exposed group. There were significant differences in NEUT, RBC and Hb (P< 0.05), but no significant differences in WBC and PLT (P>0.05). Conclusion It can not be concluded that long-term low-concentration mixed benzene exposure can cause the change of peripheral blood index.