Objective:To construct a long non-coding RNA(lncRNA)model based on ferroptosis and predict the prognosis of non-small cell lung cancer(NSCLC)patients after radiotherapy,to develop a comprehensive framework that integrates genomic data with clinical outcomes,and to identify lncRNA associated with ferroptosis and evaluate their predictive power for patient survival and progression-free survival following radiotherapy.Methods:This study commenced by acquiring standardized transcrip-tome data from primary tumors and normal tissues,along with corresponding clinical information,from the cancer genome atlas(TCGA)database.This dataset provided a robust foundation for identifying differentially expressed genes(DEGs)related to ferroptosis.These analyses helped pinpoint specific pathways and biological processes involved in ferroptosis,such as glutathione metabolism,lipid signa-ling,oxidative stress,and reactive oxygen species(ROS)metabolism.Subsequently,univariate and multivariate Cox regression analyses were conducted to construct a predictive model based on lncRNA as-sociated with ferroptosis.The goal was to differentiate between the high-risk and low-risk groups of NSCLC patients who had undergone radiotherapy.By incorporating these lncRNA into the model,we aimed to provide a more accurate prediction of patient outcomes.The performance of the model was vali-dated by comparing the survival rates and progression-free survival between the high-risk and low-risk groups.Additionally,differences in gene expression patterns and pathway activities between these two groups were examined to further validate the model's effectiveness.Results:Our analysis revealed that the differentially expressed genes related to ferroptosis were significantly enriched in several key path-ways,including ferroptosis itself,glutathione metabolism,lipid signaling,and processes involving oxida-tive stress and ROS metabolism.Based on these findings,we constructed a prognostic model using 14 lncRNA that showed strong associations with ferroptosis.Further data analysis demonstrated that these lncRNA could independently predict the prognosis of NSCLC patients after radiotherapy.Specifically,age,stage,and gender were used as clinical pathological variables,and the results indicated that the high-risk group of NSCLC patients had a poorer prognosis following radiotherapy.This finding underscores the po-tential of the model to serve as a valuable tool for predicting prognosis for NSCLC patients undergoing ra-diotherapy.Conclusion:The risk model developed in this study can independently predict the prognosis of NSCLC patients after radiotherapy.This model provides a solid basis for understanding the role of fer-roptosis-related lncRNA in the prognosis of NSCLC patients following radiotherapy.Furthermore,it offers clinical guidance for combining radiotherapy with ferroptosis-targeted treatments,potentially improving therapeutic outcomes for NSCLC patients.The integration of genomic and clinical data in this study high-lights the importance of personalized medicine approaches in oncology,paving the way for more precise and effective treatment strategies.

Collaborative diagnosis and treatment between Traditional Chinese Medicine(TCM)and Western Medicine,as an important measure for the modernization and innovation of TCM,faces great challenges such as inadequate medical resource supply and supply-demand imbalance in the context of high-quality development strategy.Supply-demand analysis and the input-output framework of modern economic theory were applied to systematically analyze the operational status of collaborative diagnosis and treatment of TCM and Western Medicine in China,and explore the intrinsic economic mechanism of its development.Furthermore,in line with the concept of the"Three Medical Synergistic Collaborations",it proposes policy recommendations from the dimension of medical care,medical insurance,and medicine.

Objective To analyze and clarify the concept and connotation of care-resistant behavior in dementia patients,so as to provide references for the evaluation and practice of care-resistant behavior in clinical dementia patients.Methods PubMed,Scopus,Web of Science,Cochrane Library,Embase,CINAHL,CNKI,VIP,Wanfang database and Chinese Biomedical Literature Database were systematically searched for the literature on care-resistant behavior in dementia patients.The search time limit was from the establishment of the database to December 2024.Walker and Avant's classical concept analysis method was used to analyze the literature.Results The care-resistant behav-ior in dementia patients included 5 conceptual attributes,including nursing background,perceived threat,unmet needs,lack of understanding and multi-dimensional performance.The antecedent factors include patient factors,care-giver factors,environmental factors and organizational factors.Post-impact includes the impact on patients and the impact on caregivers.Conclusion This study clarified the conceptual attributes,antecedents and post-effects of care-resistant behavior in dementia patients through concept analysis.In the future,researchers should combine the connotation of dementia patients' care-resistant behavior,develop localized assessment tools for dementia patients' care-resistant behavior,and construct targeted intervention programs,so as to improve the quality of nursing staff and enhance the care experience of dementia patients.

OBJECTIVE: This study aims to develop a regional collaborative hierarchical diagnosis and treatment model based on the "Internet+" approach, to address issues such as the uneven distribution of transcranial magnetic stimulation (TMS) treatment resources, information silos, and low patient accessibility in regional medical institutions. METHODS: This model establishes standardized business and information protocols, creating a real-time TMS treatment resource database, develops a regional TMS treatment management platform, and integrates with the Xiamen Health Medical Cloud Platform for collaborative operation. RESULTS: This model enables the internal communication of TMS treatment information within hospitals and sharing across medical institutions, optimizing the rational allocation of TMS treatment resources. CONCLUSION The model effectively optimizes the allocation of TMS treatment resources, significantly enhances the accessibility and quality of medical services, provides valuable insights for hierarchical diagnosis and treatment of other therapeutic models, and contributes to the development of a more organized and efficient hierarchical diagnosis and treatment system.
Transcranial Magnetic Stimulation ; Humans ; Internet

AIM:To evaluate the effect of differ-ent frequencies 0.01%atropine eye drops on the ocular surface in adolescent myopia control.METH-ODS:A total of 84 adolescent patients with myopia were recruited for this study.They were randomly assigned to receive 0.01%atropine eye drops at dif-ferent frequencies(morning group,evening group,morning and evening group).During the treatment period,ocular and systemic adverse reactions were observed,spherical equivalent refraction(SER)and axial length(AX)were examined.Additionally,ocu-lar surface disease index(OSDI)questionnaire was obtained,tear meniscus height(TMH),non-inva-sive first tear film break-up time(NifBUT),non-inva-sive average tear film break-up time(NiaBUT),and meibomian gland atrophy score(MaS)were mea-sured by Keratograph 5M.RESULTS:During the 6-month treatment with 0.01%atropine eye drops,all adverse reaction symptoms were relatively mild and infrequent.Only one case of systemic reaction was reported,with temporary xerostomia.Six pa-tients reported discomfort such as ocular itching and dryness.The ocular reactions of photophobia and blurred near vision were slightly more com-mon in the morning and combined morning-eve-ning groups compared to the evening group,but there were no significant differences among the three groups(P>0.05).Compared to baseline,there were significant differences in SER and AX among the three groups after six months of treatment(P<0.05).Compared to baseline,no significant differ-ences were observed in the Morning group after six months of treatment in terms of OSDI score(P=0.656),TMH value(P=0.362),NifBUT(P=0.510),Ni-aBUT(P=0.700),and MaS(P=0.846).Similarly,no significant changes were found in the Evening group regarding OSDI score(P=0.429),TMH value(P=0.462),NifBUT(P=0.462),NiaBUT(P=0.598),and MaS(P=0.351).Additionally,in the Morning and evening group,no significant changes were de-tected in OSDI score(P=0.457),TMH value(P=0.748),NifBUT(P=0.197),NiaBUT(P=0.070),and MaS(P=0.802)after six months of treatment.CON-CLUSION:After six months of using 0.01%atropine eye drops with different frequencies in adolescent myopia control,there was no significant impact on the ocular surface.

Objective To investigate the characteristics and clinical significance of serum immunoglob-ulins in patients with Cronkhite-Canada syndrome(CCS).Methods This retrospective study included CCS patients admitted to Peking Union Medical College Hospital from December 2009 to September 2024 who under-went serum immunoglobulin testing.Clinical manifestations and ancillary examination results were analyzed ret-rospectively.Results Fifty-two patients were included(male:36[69.2%],female:16[30.8%]),with median onset age of 60(54-64)years and median diagnostic delay of 5(3-12)months.Common manifesta-tions included diarrhea(86.5%),abdominal pain(40.4%),hematochezia(19.2%),weight loss(86.5%),nail malnutrition(100.0%),pigmentation(88.5%),hair loss(84.6%),and hypogeusia(69.2%).Serum IgG reduction occurred in 21 patients(50.0%),while total IgE elevation was observed in 20(71.4%).Elevated serum IgG4 levels were noted in 11 patients(23.4%),with no significant clinical differences between IgG4-elevated and normal groups.IgG4 levels showed no statistical difference between active(n=43)and remission(n=27)groups.The hair loss rate was significantly higher in the total IgE-ele-vated group than that in the normal total IgE group(P=0.0383).Conclusions CCS patients exhibit periph-eral blood immunoglobulin disorders,with elevated IgE levels correlating with hair loss.This suggests an im-mune-mediated mechanism may underlie hair loss in CCS.

AIM:To evaluate the effect of differ-ent frequencies 0.01%atropine eye drops on the ocular surface in adolescent myopia control.METH-ODS:A total of 84 adolescent patients with myopia were recruited for this study.They were randomly assigned to receive 0.01%atropine eye drops at dif-ferent frequencies(morning group,evening group,morning and evening group).During the treatment period,ocular and systemic adverse reactions were observed,spherical equivalent refraction(SER)and axial length(AX)were examined.Additionally,ocu-lar surface disease index(OSDI)questionnaire was obtained,tear meniscus height(TMH),non-inva-sive first tear film break-up time(NifBUT),non-inva-sive average tear film break-up time(NiaBUT),and meibomian gland atrophy score(MaS)were mea-sured by Keratograph 5M.RESULTS:During the 6-month treatment with 0.01%atropine eye drops,all adverse reaction symptoms were relatively mild and infrequent.Only one case of systemic reaction was reported,with temporary xerostomia.Six pa-tients reported discomfort such as ocular itching and dryness.The ocular reactions of photophobia and blurred near vision were slightly more com-mon in the morning and combined morning-eve-ning groups compared to the evening group,but there were no significant differences among the three groups(P>0.05).Compared to baseline,there were significant differences in SER and AX among the three groups after six months of treatment(P<0.05).Compared to baseline,no significant differ-ences were observed in the Morning group after six months of treatment in terms of OSDI score(P=0.656),TMH value(P=0.362),NifBUT(P=0.510),Ni-aBUT(P=0.700),and MaS(P=0.846).Similarly,no significant changes were found in the Evening group regarding OSDI score(P=0.429),TMH value(P=0.462),NifBUT(P=0.462),NiaBUT(P=0.598),and MaS(P=0.351).Additionally,in the Morning and evening group,no significant changes were de-tected in OSDI score(P=0.457),TMH value(P=0.748),NifBUT(P=0.197),NiaBUT(P=0.070),and MaS(P=0.802)after six months of treatment.CON-CLUSION:After six months of using 0.01%atropine eye drops with different frequencies in adolescent myopia control,there was no significant impact on the ocular surface.

Objective To investigate the characteristics and clinical significance of serum immunoglob-ulins in patients with Cronkhite-Canada syndrome(CCS).Methods This retrospective study included CCS patients admitted to Peking Union Medical College Hospital from December 2009 to September 2024 who under-went serum immunoglobulin testing.Clinical manifestations and ancillary examination results were analyzed ret-rospectively.Results Fifty-two patients were included(male:36[69.2%],female:16[30.8%]),with median onset age of 60(54-64)years and median diagnostic delay of 5(3-12)months.Common manifesta-tions included diarrhea(86.5%),abdominal pain(40.4%),hematochezia(19.2%),weight loss(86.5%),nail malnutrition(100.0%),pigmentation(88.5%),hair loss(84.6%),and hypogeusia(69.2%).Serum IgG reduction occurred in 21 patients(50.0%),while total IgE elevation was observed in 20(71.4%).Elevated serum IgG4 levels were noted in 11 patients(23.4%),with no significant clinical differences between IgG4-elevated and normal groups.IgG4 levels showed no statistical difference between active(n=43)and remission(n=27)groups.The hair loss rate was significantly higher in the total IgE-ele-vated group than that in the normal total IgE group(P=0.0383).Conclusions CCS patients exhibit periph-eral blood immunoglobulin disorders,with elevated IgE levels correlating with hair loss.This suggests an im-mune-mediated mechanism may underlie hair loss in CCS.

Objective:To construct a long non-coding RNA(lncRNA)model based on ferroptosis and predict the prognosis of non-small cell lung cancer(NSCLC)patients after radiotherapy,to develop a comprehensive framework that integrates genomic data with clinical outcomes,and to identify lncRNA associated with ferroptosis and evaluate their predictive power for patient survival and progression-free survival following radiotherapy.Methods:This study commenced by acquiring standardized transcrip-tome data from primary tumors and normal tissues,along with corresponding clinical information,from the cancer genome atlas(TCGA)database.This dataset provided a robust foundation for identifying differentially expressed genes(DEGs)related to ferroptosis.These analyses helped pinpoint specific pathways and biological processes involved in ferroptosis,such as glutathione metabolism,lipid signa-ling,oxidative stress,and reactive oxygen species(ROS)metabolism.Subsequently,univariate and multivariate Cox regression analyses were conducted to construct a predictive model based on lncRNA as-sociated with ferroptosis.The goal was to differentiate between the high-risk and low-risk groups of NSCLC patients who had undergone radiotherapy.By incorporating these lncRNA into the model,we aimed to provide a more accurate prediction of patient outcomes.The performance of the model was vali-dated by comparing the survival rates and progression-free survival between the high-risk and low-risk groups.Additionally,differences in gene expression patterns and pathway activities between these two groups were examined to further validate the model's effectiveness.Results:Our analysis revealed that the differentially expressed genes related to ferroptosis were significantly enriched in several key path-ways,including ferroptosis itself,glutathione metabolism,lipid signaling,and processes involving oxida-tive stress and ROS metabolism.Based on these findings,we constructed a prognostic model using 14 lncRNA that showed strong associations with ferroptosis.Further data analysis demonstrated that these lncRNA could independently predict the prognosis of NSCLC patients after radiotherapy.Specifically,age,stage,and gender were used as clinical pathological variables,and the results indicated that the high-risk group of NSCLC patients had a poorer prognosis following radiotherapy.This finding underscores the po-tential of the model to serve as a valuable tool for predicting prognosis for NSCLC patients undergoing ra-diotherapy.Conclusion:The risk model developed in this study can independently predict the prognosis of NSCLC patients after radiotherapy.This model provides a solid basis for understanding the role of fer-roptosis-related lncRNA in the prognosis of NSCLC patients following radiotherapy.Furthermore,it offers clinical guidance for combining radiotherapy with ferroptosis-targeted treatments,potentially improving therapeutic outcomes for NSCLC patients.The integration of genomic and clinical data in this study high-lights the importance of personalized medicine approaches in oncology,paving the way for more precise and effective treatment strategies.

Collaborative diagnosis and treatment between Traditional Chinese Medicine(TCM)and Western Medicine,as an important measure for the modernization and innovation of TCM,faces great challenges such as inadequate medical resource supply and supply-demand imbalance in the context of high-quality development strategy.Supply-demand analysis and the input-output framework of modern economic theory were applied to systematically analyze the operational status of collaborative diagnosis and treatment of TCM and Western Medicine in China,and explore the intrinsic economic mechanism of its development.Furthermore,in line with the concept of the"Three Medical Synergistic Collaborations",it proposes policy recommendations from the dimension of medical care,medical insurance,and medicine.