Objective To investigate the effect of impression method with silicone impression material for full denture of edentulous jaw.Methods A total of 53 patients with edentulous jaw underwent full denture restoration in the Second Affiliated Hospital of Zhejiang Chinese Medical University from January 2023 to January 2024 were selected.Patients were randomly treated with impression method with red paste combined alginate or silicone impression material for full denture impression according to the order of treatment.A return visit was made and the clinical effect satisfaction questionnaire was filled in after the full denture was worn and used for one week.Logistic regression was used to analyze the interaction between each factor and different impression methods.Results Of the 53 patients,28 cases were treated with silicone impression material and 25 cases were freated with red paste combined alginate impression material.The satisfaction of silicone impression material was significantly higher than that of red paste combined alginate impression material(96.43％vs.72.00％,x2=4.390,P=0.036),and there was no interaction between the use of different impression methods and gender,maxillary and mandible,classification on of edentulous jaws(P＞0.05).Conclusion For patients with edentulous jaw,impression method of silicone impression material can be selected to make impression for full denture,so as to improve the effect of full denture restoration in elderly patients with edentulous jaw.

HDAC7, a member of class IIa HDACs, plays a pivotal regulatory role in tumor, immune, fibrosis, and angiogenesis, rendering it a potential therapeutic target. Nevertheless, due to the high similarity in the enzyme active sites of class IIa HDACs, inhibitors encounter challenges in discerning differences among them. Furthermore, the substitution of key residue in the active pocket of class IIa HDACs renders them pseudo-enzymes, leading to a limited impact of enzymatic inhibitors on their function. In this study, proteolysis targeting chimera (PROTAC) technology was employed to develop HDAC7 drugs. We developed an exceedingly selective HDAC7 PROTAC degrader B14 which showcased superior inhibitory effects on cell proliferation compared to TMP269 in various diffuse large B cell lymphoma (DLBCL) and acute myeloid leukemia (AML) cells. Subsequent investigations unveiled that B14 disrupts BCL6 forming a transcriptional inhibition complex by degrading HDAC7, thereby exerting proliferative inhibition in DLBCL. Our study broadened the understanding of the non-enzymatic functions of HDAC7 and underscored the importance of HDAC7 in the treatment of hematologic malignancies, particularly in DLBCL and AML.

Objective To investigate the effect of impression method with silicone impression material for full denture of edentulous jaw.Methods A total of 53 patients with edentulous jaw underwent full denture restoration in the Second Affiliated Hospital of Zhejiang Chinese Medical University from January 2023 to January 2024 were selected.Patients were randomly treated with impression method with red paste combined alginate or silicone impression material for full denture impression according to the order of treatment.A return visit was made and the clinical effect satisfaction questionnaire was filled in after the full denture was worn and used for one week.Logistic regression was used to analyze the interaction between each factor and different impression methods.Results Of the 53 patients,28 cases were treated with silicone impression material and 25 cases were freated with red paste combined alginate impression material.The satisfaction of silicone impression material was significantly higher than that of red paste combined alginate impression material(96.43％vs.72.00％,x2=4.390,P=0.036),and there was no interaction between the use of different impression methods and gender,maxillary and mandible,classification on of edentulous jaws(P＞0.05).Conclusion For patients with edentulous jaw,impression method of silicone impression material can be selected to make impression for full denture,so as to improve the effect of full denture restoration in elderly patients with edentulous jaw.

Objective:To investigate the effects of perioperative whole course thermal insulation strategy on extubation, recovery time, coagulation index and the incidence of complications in patients undergoing thoracoscopic surgery.Methods:A total of 121 patients who underwent thoracoscopic surgery who received treatment in Zhoushan Hospital from October 2016 to February 2018 were included in this study. Among them, 59 patients who underwent thoracoscopic surgery from October 2016 to February 2017 were included in the simple thermal insulation group, and 62 patients who underwent thoracoscopic surgery from October 2017 to February 2018 were included in the whole process thermal insulation group. Before and 24 hours and 72 hours after surgery, platelet count, prothrombin time, activated partial thromboplastin time and thrombin time were compared between the two groups. Postoperative extubation time and recovery time were recorded. The incidence of shivering, restlessness and other complications was analyzed.Results:Postoperative extubation time and recovery time in the whole process thermal insulation group were significantly shorter than those in the simple thermal insulation group [(8.06 ± 4.60) min vs. (13.98 ± 7.22) min, (47.19 ± 12.97) min vs. (56.84 ± 17.49) min, t = 5.40, 3.47, both P < 0.05). At 24 and 72 hours after surgery, platelet count and activated partial prothrombin time in the whole process thermal insulation group were significantly shorter than those in the simple thermal insulation group [(12.55 ± 0.88) s vs. (13.11 ± 0.97) s, (27.44 ± 2.43) s vs. (29.03 ± 2.14) s, (11.42 ± 0.73) s vs. (11.87 ± 0.74) s, (27.44 ± 1.96) s vs. (28.80 ± 2.22) s, t = 3.32, 3.81, all P < 0.05). The incidence of postoperative shivering and restlessness in the whole process thermal insulation group was significantly lower than that in the simple insulation Group (7 cases vs. 27 cases, 5 cases vs. 22 cases, χ2 = 17.782, 14.894, 3.33, 3.57, all P < 0.05). Conclusion:Perioperative whole course thermal insulation strategy can shorten extubation and recovery time, inhibit perioperative coagulation dysfunction, and decrease the incidence of perioperative restlessness, shivering and other complications caused by hypothermia. The effect of perioperative whole course thermal insulation is superior to that of simple thermal insulation.

Objective To discuss the feasibility of Monte Carlo N-particle transport code(MCNP)simulated calculation.Methods The calculation in water phantom was contrasted with the practical measurements and the reported values using the percent depth dose(PDD)curve and normal peak scatter factor.Results There Was no significant difference between calculated and measured results in the 10 cm×10 cm field(t＝-0.41,P>0.05),however,there were significant differences in the 5 cm×5 cm field(t=7.2,P<0.05)and in the 12 cm×12 cm field(t=-4.6,P<0.05).There was no significant difierence between the calculated results and the reported values(t=-1.91,P>0.05).In the same radiation field,the PDD decreased as the depth increased,but increased as the size of the radiation field increased at the same depth.PDD and normal peak scatter factor were both important parameters for calculation of prescribed dose.Conclusions It is possible to establish a set of accurate and comprehensive percent depth doses and normal peak scatter factor parameters so as to provide the basis of clinical use, quality assurance and quality control for radiotherapy.