Approximately one-third of stroke patients experience post-stroke cognitive impairment(PSCI),which significantly impacts their quality of life and survival time.The clinical evaluations of PSCI mainly rely on subjective neurophysiological scales due to its complex pathogenesis and lack of reliable,objective diagnostic tools.However,electroencephalogram(EEG)and magnetic resonance imaging(MRI)could provide objective indicators for diagnosis of PSCI.Based on EEG,MRI and EEG-MRI fusion,this article reviews recent advances in the central mechanisms of PSCI,focusing on changes in brainwave spectrum,brain structure,brain network etc.,in order to explore the clinical values of EEG and MRI in predicting and diagnosing PSCI,enhance the understanding of its pathogenesis and provide a basis for accurate clinical diagnosis.

Post-stroke depression(PSD),a common stroke complication characterized by depressed mood and diminished interest,severely affects patients'recovery and quality of life.Microglial abnormal activation and polarization play key roles in PSD pathogenesis,closely associated with neuroinflammation and imbalance in neu-rotransmitter metabolism.In contrast,traditional Chinese medicine(TCM)demonstrates unique multi-target and multi-level mechanisms:regulating microglial function,ameliorating post-stroke neuroinflammatory environments,and promoting neuroplasticity,thereby potentially alleviating PSD symptoms.This review summarizes TCM's effects on microglial activation/polarization states and its therapeutic advances in PSD,providing novel perspectives and strategies for clinical management.

Post-stroke depression(PSD),a common stroke complication characterized by depressed mood and diminished interest,severely affects patients'recovery and quality of life.Microglial abnormal activation and polarization play key roles in PSD pathogenesis,closely associated with neuroinflammation and imbalance in neu-rotransmitter metabolism.In contrast,traditional Chinese medicine(TCM)demonstrates unique multi-target and multi-level mechanisms:regulating microglial function,ameliorating post-stroke neuroinflammatory environments,and promoting neuroplasticity,thereby potentially alleviating PSD symptoms.This review summarizes TCM's effects on microglial activation/polarization states and its therapeutic advances in PSD,providing novel perspectives and strategies for clinical management.

Ischemic stroke is a neurological disease that damages brain tissue as a result of an insufficient blood supply to the brain,due to blockage or stenosis of the brain vessels.Increasing evidence has indicated that the Wnt/β-catenin signaling pathway plays an important role in the pathophysiological response to the occurrence and development of ischemic stroke.Programmed cell death includes many forms,such as apoptosis,necrotic apoptosis,pyroptosis,autophagy,PANoptosis,and ferroptosis.In this review,we elucidate the characteristics of these different modes of cell death and their cross-talk relationships with each other,and systematically outline the role of Wnt/β-catenin signaling pathways in the intervention of different cell death modes in ischemic stroke,with the aim of providing references for future clinical and basic research studies.