Transcatheter renal denervation therapy for hypertension has undergone development over a decade,a considerable amount of clinical research evidences have been accumulated.There are different devices developed based on the radio frequency,ultrasound,chemistry,and cryoablation techniques and selection of ablation targets has been optimized gradually.Transcatheter renal denervation may become an important treatment option for hypertension in the future.This article aims to systematically elucidate the technical principles,clinical evidence of transcatheter renal denervation results with different devices,the limitations,and prospects for application of various denervation techniques.

Transcatheter renal denervation therapy for hypertension has undergone development over a decade,a considerable amount of clinical research evidences have been accumulated.There are different devices developed based on the radio frequency,ultrasound,chemistry,and cryoablation techniques and selection of ablation targets has been optimized gradually.Transcatheter renal denervation may become an important treatment option for hypertension in the future.This article aims to systematically elucidate the technical principles,clinical evidence of transcatheter renal denervation results with different devices,the limitations,and prospects for application of various denervation techniques.