Parkinson's disease （PD） is a complex neurodegenerative disease involving multiple systems and neurotransmitters. Due to the high clinical heterogeneity of PD，it is urgent to establish a comprehensive and long-term traditional Chinese medicine （TCM） management model. In this paper，the conceptual framework of full-cycle management of PD is preliminarily constructed：based on the evolution of the pathophysiological mechanisms of protein deposition and neurotransmitter disorder in PD，the three-stage syndrome characteristics of the prodromal stage （predominant healthy Qi with subtle pathogenic factors），the early clinical stage （declining healthy Qi with growing pathogenic factors） and the middle and late stages （overwhelming pathogenic factors with deficient healthy Qi） are longitudinally described. Through the syndrome differentiation of visceral manifestations，the etiology and pathogenesis of PD motor and non-motor symptoms were comprehensively analyzed，while the matching treatment methods and prescriptions were inferred，and the modular scheme of the combining main symptoms，accompanying symptoms and secondary symptoms was proposed. The conceptual gap of TCM regarding motor complications （'variable syndrome'） and PD-related hyperpyrexia syndrome （'critical syndrome'） was explained. This framework reflects the characteristics of combination of disease and syndrome and overall constant motion，and provides new theories and research ideas for individualized and whole-process management of PD in TCM.

Parkinson's disease （PD） is a complex neurodegenerative disease involving multiple systems and neurotransmitters. Due to the high clinical heterogeneity of PD，it is urgent to establish a comprehensive and long-term traditional Chinese medicine （TCM） management model. In this paper，the conceptual framework of full-cycle management of PD is preliminarily constructed：based on the evolution of the pathophysiological mechanisms of protein deposition and neurotransmitter disorder in PD，the three-stage syndrome characteristics of the prodromal stage （predominant healthy Qi with subtle pathogenic factors），the early clinical stage （declining healthy Qi with growing pathogenic factors） and the middle and late stages （overwhelming pathogenic factors with deficient healthy Qi） are longitudinally described. Through the syndrome differentiation of visceral manifestations，the etiology and pathogenesis of PD motor and non-motor symptoms were comprehensively analyzed，while the matching treatment methods and prescriptions were inferred，and the modular scheme of the combining main symptoms，accompanying symptoms and secondary symptoms was proposed. The conceptual gap of TCM regarding motor complications （'variable syndrome'） and PD-related hyperpyrexia syndrome （'critical syndrome'） was explained. This framework reflects the characteristics of combination of disease and syndrome and overall constant motion，and provides new theories and research ideas for individualized and whole-process management of PD in TCM.

Objective:To analyze the risk factors of hearing loss caused by neonatal cytomegalovirus (CMV) infection, to construct a nomogram prediction model, and to evaluate its discrimination and consistency.Methods:Data of a total of 250 neonates with congenital and perinatal CMV infection who were treated in our hospital from June 2018 to March 2021 were collected, and grouped into hearing-impaired group of 50 cases and hearing-unimpaired group of 200 cases according to whether the hearing was impaired or not. Logistic regression analysis was performed to analyze the risk factors affecting hearing loss caused by CMV infection in neonates. R software was applied to construct a nomogram model for predicting the risk of hearing loss caused by CMV infection in neonates, and the ROC curve and calibration curve were analyzed to verify the discrimination and consistency of the nomogram model.Results:Among 250 CMV-infected neonates in the modeling group, the incidence of hearing impairment was 20.00%. The proportion of primary maternal infection before 14 weeks of gestation, the proportion of urine CMV viral load >5×10 4 copies/ml, the proportion of symptomatic CMV infection and the proportion of abnormal head MRI in the hearing-impaired group were significantly higher than those in the hearing-unimpaired group ( χ2=12.545, 11.812, 11.801, and 9.025, P=0.000, 0.001, 0.001, and 0.003). That urine CMV viral load>5×10 4 copies/ml, symptomatic CMV infection and abnormal head MRI were the risk factors affecting hearing loss caused by CMV infection in neonates ( OR=2.388, 6.765, and 4.993, P=0.022, 0.000, and 0.001), the prediction model of the line graph was constructed using Bootstrap internal verification, Hosmer-Lemeshow goodness of fit test =6.055, P=0.301, area under ROC curve was 0.817, 95% CI=0.754~0.880, and external verification result showed that the predicted probability of the calibration curve was close to the actual probability and has a good agreement, with an AUC of 0.791 (95% CI=0.716~0.866). Conclusions:The nomogram model constructed in this study to predict the risk of hearing loss caused by CMV infection in neonates can be used for the prediction of hearing loss in neonates after CMV infection.