1.Advances in fat mass and obesity-related protein-mediated N6-adenylate methylation in atherosclerosis
Zhuoyi XIE ; Songtao CHEN ; Xuan SUN ; Peijuan YANG ; Yali CHEN ; Qinjun GUI ; Jianhong ZUO
Chinese Journal of Arteriosclerosis 2025;33(3):257-263
N6-methyladenosine(m6A)is the most common mRNA modification in eukaryotes,and fat mass and obesity-related protein(FTO),are its demethylases,which efficiently remove the modification of m6A mRNA,and is strongly associated with obesity.Atherosclerosis is a chronic inflammatory lesion of the blood vessel wall driven by lipids.It was found that FTO-mediated m6A may influence the process of atherosclerosis through lipid metabolism,oxidative stress,mitochondrial dysfunction,and macrophage foaminess.
2.Advances in fat mass and obesity-related protein-mediated N6-adenylate methylation in atherosclerosis
Zhuoyi XIE ; Songtao CHEN ; Xuan SUN ; Peijuan YANG ; Yali CHEN ; Qinjun GUI ; Jianhong ZUO
Chinese Journal of Arteriosclerosis 2025;33(3):257-263
N6-methyladenosine(m6A)is the most common mRNA modification in eukaryotes,and fat mass and obesity-related protein(FTO),are its demethylases,which efficiently remove the modification of m6A mRNA,and is strongly associated with obesity.Atherosclerosis is a chronic inflammatory lesion of the blood vessel wall driven by lipids.It was found that FTO-mediated m6A may influence the process of atherosclerosis through lipid metabolism,oxidative stress,mitochondrial dysfunction,and macrophage foaminess.
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