Transarterial radioembolization (TARE) is a widely utilized therapeutic approach for hepatocellular carcinoma (HCC), however, the clinical implementation is constrained by the stringent preparation conditions of radioembolization agents. Herein, we incorporated the superstable homogeneous iodinated formulation technology (SHIFT), simultaneously utilizing an enhanced solvent form in a carbon dioxide supercritical fluid environment, to encapsulate radionuclides (such as ¹³¹I,¹⁷⁷Lu, or ¹⁸F) with lipiodol for the preparation of radiolipiodol. The resulting radiolipiodol exhibited exceptional stability and ultra-high labeling efficiency (≥99%) and displayed notable intratumoral radionuclide retention and in vivo stability more than 2 weeks following locoregional injection in subcutaneous tumors in mice and orthotopic liver tumors in rats and rabbits. Given these encouraging findings, ¹⁸F was authorized as a radiotracer in radiolipiodol for clinical trials in HCC patients, and showed a favorable tumor accumulation, with a tumor-to-liver uptake ratio of ≥50 and minimal radionuclide leakage, confirming the feasibility of SHIFT for TARE applications. In the context of transforming from preclinical to clinical screening, the preparation of radiolipiodol by SHIFT represents an innovative physical strategy for radionuclide encapsulation. Hence, this work offers a reliable and efficient approach for TARE in HCC, showing considerable promise for clinical application (ChiCTR2400087731).

Objective:To discuss the effects of superelastic nickel-titanium archwires(SENT)and heat-activated nickel-titanium archwires(HANT)on the initial alignment efficiency of mandibular anterior teeth and pain levels of the patients with extraction orthodontic treatment and non-extraction orthodontic treatment by using low-friction self-ligating brackets,and to provide the basis for the selection of the most suitable archwire in orthodontic clinical practice.Methods:Eighty patients underwent fixed orthodontic treatment with self-ligating brackets were randomly assigned to SENT or HANT subgroups,and there were 40 patients in extraction orthodontic treatment group and 40 patients in non-extraction orthodontic treatment group.A single operator fully engaged a 0.014-inch straight archwire into the brackets.The patients,operators,and data measurers were all blinded;the initial clinical alignment efficiency of the archwires of the patients in various groups was observed,and the Little's index was calculated;the visual analog scale(VAS)scores and pain perception of the patients in various groups were recorded 4 h after initial bonding of the appliances and every day before breakfast during the first week of orthodontic treatment;multivariate regression analysis was performed for the initial Little's index,gender,and age,and the influence factors of pain in the patients was analyzed.Results:There were no significant differences in age,gender,and initial Little's index among the patients in extraction group and non-extraction group(P＞0.05).Compared with before treatment,the Little's indexes of the patients in both HANT and SENT subgroups in non-extraction orthedontic treatment group were decreased 4 weeks after treatment,but the difference between groups was not significant(P＞0.05).Compared with SENT subgroup in non-extraction orthodontic treatment group,the Little's index of the patients in HANT subgroup was decreased(P＜0.05).In extraction orthodontic treatment group,there were no significant differences in Little's indexes of the patients between the HANT and SENT subgroups before and after treatment(P＞0.05).The pain perception peaked on the first day after initial bonding and gradually decreased to baseline levels.The patients in SENT and HANT subgroups in both extraction and non-extraction orthodontic treatment groups showed the similar patterns of pain change.There were no significant differences in the average VAS scores and maximum pain intensity scores between the patients in SENT and HANT subgroups at different time points(P＞0.05).The type of archwire had no significant effect on the degree of pain,while time significantly affected the degree of pain.The multivariate regression analysis results showed a significant correlation between initial Little's index and maximum VAS scores of the patients in extraction orthodontic treatment group(b=0.359,P=0.033).Gender and age did not affect the degree of pain of the patients in either group.Conclusion:When applying low-friction self-ligating brackets for orthodontic treatment,the initial alignment efficiency with 0.014-inch HANT archwires is superior to 0.014-inch SENT archwires in non-extraction treatment group,while both archwires show the same efficiency in extraction patients.SENT and HANT archwires do not affect the initial degrees of pain of the orthodontic patients.

Objective This study aimed to explore the root length of maxillary and mandibular anterior teeth and central incisor crown-root morphology in patients with high-angle skeletal Class Ⅱ open bite,aiming to provide a refer-ence for clinical treatment.Methods This study was reviewed and approved by the Ethics Committee,and informed consent was obtained from the patients.CBCT images of eighty-one untreated patients(40 anterior open bite patients and 41 normal overbite patients)with high-angle skeletal Class Ⅱ malocclusion were selected before treatment.Dolphin software was used to study the root length of maxillary and mandibular anterior teeth and central incisor crown-root mor-phology,and the differences between the two groups were analyzed.Results There was no statistical significance in the root length of maxillary lateral incisor and canine between the open bite group and the normal overbite group,signifi-cant differences were found in the root length of maxillary central incisor(11.12±1.37)mm、mandibular central inci-sor(10.15±1.09)mm,mandibular lateral incisor(11.27±1.15)mm and mandibular canine(12.81±1.48)mm be-tween the open bite group and the normal overbite group(P＜0.05).On the other hand,the two groups were significant-ly different in crown-root morphology of the maxillary central incisor(1.10°±3.62° vs.4.53°±2.30°,P＜0.01)but not in the mandibular central incisor.Conclusion The root length of the maxillary central incisor,mandibular central inci-sor,mandibular lateral incisor,mandibular canine in high-angle Class Ⅱ open bite patients is shorter than that in high-angle Class Ⅱ normal overbite patients,and the long axis of the crown of the maxillary central incisor in high-angle Class Ⅱ open bite patients obviously deviates toward the labial side relative to the long axis of the root.The crown-root angle is smaller,which is beneficial to torque control or adduction movement of the anterior teeth in high-angle Class Ⅱopen bite patients.

Objective This study aimed to explore the root length of maxillary and mandibular anterior teeth and central incisor crown-root morphology in patients with high-angle skeletal Class Ⅱ open bite,aiming to provide a refer-ence for clinical treatment.Methods This study was reviewed and approved by the Ethics Committee,and informed consent was obtained from the patients.CBCT images of eighty-one untreated patients(40 anterior open bite patients and 41 normal overbite patients)with high-angle skeletal Class Ⅱ malocclusion were selected before treatment.Dolphin software was used to study the root length of maxillary and mandibular anterior teeth and central incisor crown-root mor-phology,and the differences between the two groups were analyzed.Results There was no statistical significance in the root length of maxillary lateral incisor and canine between the open bite group and the normal overbite group,signifi-cant differences were found in the root length of maxillary central incisor(11.12±1.37)mm、mandibular central inci-sor(10.15±1.09)mm,mandibular lateral incisor(11.27±1.15)mm and mandibular canine(12.81±1.48)mm be-tween the open bite group and the normal overbite group(P＜0.05).On the other hand,the two groups were significant-ly different in crown-root morphology of the maxillary central incisor(1.10°±3.62° vs.4.53°±2.30°,P＜0.01)but not in the mandibular central incisor.Conclusion The root length of the maxillary central incisor,mandibular central inci-sor,mandibular lateral incisor,mandibular canine in high-angle Class Ⅱ open bite patients is shorter than that in high-angle Class Ⅱ normal overbite patients,and the long axis of the crown of the maxillary central incisor in high-angle Class Ⅱ open bite patients obviously deviates toward the labial side relative to the long axis of the root.The crown-root angle is smaller,which is beneficial to torque control or adduction movement of the anterior teeth in high-angle Class Ⅱopen bite patients.

Objective This study aimed to explore the root length of maxillary and mandibular anterior teeth and central incisor crown-root morphology in patients with high-angle skeletal Class Ⅱ open bite,aiming to provide a refer-ence for clinical treatment.Methods This study was reviewed and approved by the Ethics Committee,and informed consent was obtained from the patients.CBCT images of eighty-one untreated patients(40 anterior open bite patients and 41 normal overbite patients)with high-angle skeletal Class Ⅱ malocclusion were selected before treatment.Dolphin software was used to study the root length of maxillary and mandibular anterior teeth and central incisor crown-root mor-phology,and the differences between the two groups were analyzed.Results There was no statistical significance in the root length of maxillary lateral incisor and canine between the open bite group and the normal overbite group,signifi-cant differences were found in the root length of maxillary central incisor(11.12±1.37)mm、mandibular central inci-sor(10.15±1.09)mm,mandibular lateral incisor(11.27±1.15)mm and mandibular canine(12.81±1.48)mm be-tween the open bite group and the normal overbite group(P＜0.05).On the other hand,the two groups were significant-ly different in crown-root morphology of the maxillary central incisor(1.10°±3.62° vs.4.53°±2.30°,P＜0.01)but not in the mandibular central incisor.Conclusion The root length of the maxillary central incisor,mandibular central inci-sor,mandibular lateral incisor,mandibular canine in high-angle Class Ⅱ open bite patients is shorter than that in high-angle Class Ⅱ normal overbite patients,and the long axis of the crown of the maxillary central incisor in high-angle Class Ⅱ open bite patients obviously deviates toward the labial side relative to the long axis of the root.The crown-root angle is smaller,which is beneficial to torque control or adduction movement of the anterior teeth in high-angle Class Ⅱopen bite patients.

Objective This study aimed to explore the root length of maxillary and mandibular anterior teeth and central incisor crown-root morphology in patients with high-angle skeletal Class Ⅱ open bite,aiming to provide a refer-ence for clinical treatment.Methods This study was reviewed and approved by the Ethics Committee,and informed consent was obtained from the patients.CBCT images of eighty-one untreated patients(40 anterior open bite patients and 41 normal overbite patients)with high-angle skeletal Class Ⅱ malocclusion were selected before treatment.Dolphin software was used to study the root length of maxillary and mandibular anterior teeth and central incisor crown-root mor-phology,and the differences between the two groups were analyzed.Results There was no statistical significance in the root length of maxillary lateral incisor and canine between the open bite group and the normal overbite group,signifi-cant differences were found in the root length of maxillary central incisor(11.12±1.37)mm、mandibular central inci-sor(10.15±1.09)mm,mandibular lateral incisor(11.27±1.15)mm and mandibular canine(12.81±1.48)mm be-tween the open bite group and the normal overbite group(P＜0.05).On the other hand,the two groups were significant-ly different in crown-root morphology of the maxillary central incisor(1.10°±3.62° vs.4.53°±2.30°,P＜0.01)but not in the mandibular central incisor.Conclusion The root length of the maxillary central incisor,mandibular central inci-sor,mandibular lateral incisor,mandibular canine in high-angle Class Ⅱ open bite patients is shorter than that in high-angle Class Ⅱ normal overbite patients,and the long axis of the crown of the maxillary central incisor in high-angle Class Ⅱ open bite patients obviously deviates toward the labial side relative to the long axis of the root.The crown-root angle is smaller,which is beneficial to torque control or adduction movement of the anterior teeth in high-angle Class Ⅱopen bite patients.

Objective This study aimed to explore the root length of maxillary and mandibular anterior teeth and central incisor crown-root morphology in patients with high-angle skeletal Class Ⅱ open bite,aiming to provide a refer-ence for clinical treatment.Methods This study was reviewed and approved by the Ethics Committee,and informed consent was obtained from the patients.CBCT images of eighty-one untreated patients(40 anterior open bite patients and 41 normal overbite patients)with high-angle skeletal Class Ⅱ malocclusion were selected before treatment.Dolphin software was used to study the root length of maxillary and mandibular anterior teeth and central incisor crown-root mor-phology,and the differences between the two groups were analyzed.Results There was no statistical significance in the root length of maxillary lateral incisor and canine between the open bite group and the normal overbite group,signifi-cant differences were found in the root length of maxillary central incisor(11.12±1.37)mm、mandibular central inci-sor(10.15±1.09)mm,mandibular lateral incisor(11.27±1.15)mm and mandibular canine(12.81±1.48)mm be-tween the open bite group and the normal overbite group(P＜0.05).On the other hand,the two groups were significant-ly different in crown-root morphology of the maxillary central incisor(1.10°±3.62° vs.4.53°±2.30°,P＜0.01)but not in the mandibular central incisor.Conclusion The root length of the maxillary central incisor,mandibular central inci-sor,mandibular lateral incisor,mandibular canine in high-angle Class Ⅱ open bite patients is shorter than that in high-angle Class Ⅱ normal overbite patients,and the long axis of the crown of the maxillary central incisor in high-angle Class Ⅱ open bite patients obviously deviates toward the labial side relative to the long axis of the root.The crown-root angle is smaller,which is beneficial to torque control or adduction movement of the anterior teeth in high-angle Class Ⅱopen bite patients.

Objective This study aimed to explore the root length of maxillary and mandibular anterior teeth and central incisor crown-root morphology in patients with high-angle skeletal Class Ⅱ open bite,aiming to provide a refer-ence for clinical treatment.Methods This study was reviewed and approved by the Ethics Committee,and informed consent was obtained from the patients.CBCT images of eighty-one untreated patients(40 anterior open bite patients and 41 normal overbite patients)with high-angle skeletal Class Ⅱ malocclusion were selected before treatment.Dolphin software was used to study the root length of maxillary and mandibular anterior teeth and central incisor crown-root mor-phology,and the differences between the two groups were analyzed.Results There was no statistical significance in the root length of maxillary lateral incisor and canine between the open bite group and the normal overbite group,signifi-cant differences were found in the root length of maxillary central incisor(11.12±1.37)mm、mandibular central inci-sor(10.15±1.09)mm,mandibular lateral incisor(11.27±1.15)mm and mandibular canine(12.81±1.48)mm be-tween the open bite group and the normal overbite group(P＜0.05).On the other hand,the two groups were significant-ly different in crown-root morphology of the maxillary central incisor(1.10°±3.62° vs.4.53°±2.30°,P＜0.01)but not in the mandibular central incisor.Conclusion The root length of the maxillary central incisor,mandibular central inci-sor,mandibular lateral incisor,mandibular canine in high-angle Class Ⅱ open bite patients is shorter than that in high-angle Class Ⅱ normal overbite patients,and the long axis of the crown of the maxillary central incisor in high-angle Class Ⅱ open bite patients obviously deviates toward the labial side relative to the long axis of the root.The crown-root angle is smaller,which is beneficial to torque control or adduction movement of the anterior teeth in high-angle Class Ⅱopen bite patients.

Objective This study aimed to explore the root length of maxillary and mandibular anterior teeth and central incisor crown-root morphology in patients with high-angle skeletal Class Ⅱ open bite,aiming to provide a refer-ence for clinical treatment.Methods This study was reviewed and approved by the Ethics Committee,and informed consent was obtained from the patients.CBCT images of eighty-one untreated patients(40 anterior open bite patients and 41 normal overbite patients)with high-angle skeletal Class Ⅱ malocclusion were selected before treatment.Dolphin software was used to study the root length of maxillary and mandibular anterior teeth and central incisor crown-root mor-phology,and the differences between the two groups were analyzed.Results There was no statistical significance in the root length of maxillary lateral incisor and canine between the open bite group and the normal overbite group,signifi-cant differences were found in the root length of maxillary central incisor(11.12±1.37)mm、mandibular central inci-sor(10.15±1.09)mm,mandibular lateral incisor(11.27±1.15)mm and mandibular canine(12.81±1.48)mm be-tween the open bite group and the normal overbite group(P＜0.05).On the other hand,the two groups were significant-ly different in crown-root morphology of the maxillary central incisor(1.10°±3.62° vs.4.53°±2.30°,P＜0.01)but not in the mandibular central incisor.Conclusion The root length of the maxillary central incisor,mandibular central inci-sor,mandibular lateral incisor,mandibular canine in high-angle Class Ⅱ open bite patients is shorter than that in high-angle Class Ⅱ normal overbite patients,and the long axis of the crown of the maxillary central incisor in high-angle Class Ⅱ open bite patients obviously deviates toward the labial side relative to the long axis of the root.The crown-root angle is smaller,which is beneficial to torque control or adduction movement of the anterior teeth in high-angle Class Ⅱopen bite patients.

ObjectiveTo explore the protective effect and mechanism of Zingiberis Rhizoma Recens alcohol extract on lipopolysaccharide （LPS）-induced acute lung injury in mice. MethodBalb/c mice were randomly divided into normal group， model group， dexamethasone group， and low- and high-dose Zingiberis Rhizoma Recens groups. Mice in the normal group were instilled with normal saline through the nose， and the other groups were instilled with normal saline containing LPS （50 μg）. After 30 minutes of modeling， the dexamethasone group was gavaged with 5 mg·kg^-1 of dexamethasone acetate solution， the low- and high-dose Zingiberis Rhizoma Recens groups were gavaged with different doses of （7， 14 g·kg^-1） of Zingiberis Rhizoma Recens alcohol extract， and the normal group and the model group were gavaged with the same volume of water. After 24 hours of modeling， the total number of white blood cells in bronchoalceolar lavage fluid （BALF） was detected by cell counter， and the levels of the inflammatory factors including tumor necrosis factor （TNF）-α， interleukin （IL）-1β， IL-6， and superoxide dismutase （SOD）， and myeloperoxidase （MPO） was detected by enzyme-linked immunosorbent assay （ELISA）. Haematoxylin-eosin （HE） staining method was used to observe the pathological changes of lung tissue in each group， and the Western blot was used to detect the protein expression of nuclear transcription factor （NF）-κB p65， phosphorylation （p）-NF-κB p65， and Toll-like receptor 4 （TLR4） in lung tissue. ResultCompared with the normal group， the white blood cell count in BALF and the levels of TNF-α， IL-1β， IL-6， and MPO in the model group was increased （P<0.01）， and the level of SOD was decreased （P<0.05）. Pathological damage of lung tissue was obvious， and the protein expression of NF-κB p65， p-NF-κB p65， and TLR4 in lung tissue was increased （P<0.01）. Compared with the model group， the white blood cell count in BALF and the levels of TNF-α， IL-1β， IL-6， and MPO in the treatment group was decreased （P<0.05，P<0.01）， and the level of SOD was increased （P<0.05，P<0.01）. Pathological damage of lung tissue was alleviated， and the protein expression of NF-κB p65， p-NF-κB p65， and TLR4 in lung tissue was decreased （P<0.01）. ConclusionZingiberis Rhizoma Recens alcohol extract may play a protective role in LPS-induced acute lung injury in mice by inhibiting the TLR4/NF-κB signaling pathway.