This article aims to summarize the nursing experience of a patient with Hashimoto's encephalopathy accompanied by cerebral edema and epileptic seizures.The key nursing points:to strengthen nursing care for cerebral edema and intracranial hypertension to reduce brain injury;to comprehensively manage epileptic seizures to prevent and control serious complications;to carry out personalized Double Filtration Plasmapheresis nursing to optimize treatment effectiveness;to take proactive nursing measures to reduce the risk of infection;to implement multiple forms of psychological care to alleviate negative emotions of the patient and his families;to provide health guidance and regular follow-up to enhance the disease management capabilities of patients and his families.After 27 days of active treatment and meticulous care,the patient recovered and was discharged,with a good recovery during follow-up.

This article aims to summarize the nursing experience of a patient with Hashimoto's encephalopathy accompanied by cerebral edema and epileptic seizures.The key nursing points:to strengthen nursing care for cerebral edema and intracranial hypertension to reduce brain injury;to comprehensively manage epileptic seizures to prevent and control serious complications;to carry out personalized Double Filtration Plasmapheresis nursing to optimize treatment effectiveness;to take proactive nursing measures to reduce the risk of infection;to implement multiple forms of psychological care to alleviate negative emotions of the patient and his families;to provide health guidance and regular follow-up to enhance the disease management capabilities of patients and his families.After 27 days of active treatment and meticulous care,the patient recovered and was discharged,with a good recovery during follow-up.

3' Untranslated Regions ; Animals ; Biomarkers ; metabolism ; Cell Proliferation ; Cell Survival ; Embryonic Stem Cells ; cytology ; metabolism ; Induced Pluripotent Stem Cells ; cytology ; metabolism ; Mice ; Swine ; Transcription Factors ; genetics ; metabolism

OBJECTIVETo study the preparation ofnanostructured lipid carriers loaded with supercritical carbon dioxide fluid extraction of Xionggui powder.

METHODPrepared nanostructured lipid carriers (NLC) loaded with supercritical carbon dioxide fluid extraction of Xionggui powder (XG-CO2-SFE) with a microemulsion ultrasonication method , established the best prescription of XG-CO2-SFE-NLC by orthogonal design methods with entrapment efficiency of nanoparticles as index, and investigated their physicochemical characterizations.

RESULTThe best prescription was m(phospholipid) : m(S-40) : m(lipid carriers) = 5 : 2 : 1, the entrapment efficiency of nanopartices was 86.8%, results revealed that nanoparticles were sphere like with the mean size of 92.6 nm and the mean zeta potential was -20.68 mV.

CONCLUSIONThe prep aration method of the XG-CO2-SFE-NLC is appropriate.

Carbon Dioxide ; chemistry ; Chromatography, Supercritical Fluid ; Drug Carriers ; chemistry ; Drugs, Chinese Herbal ; chemistry ; isolation & purification ; Emulsions ; Linear Models ; Lipids ; chemistry ; Nanostructures ; chemistry ; Powders