Objective:To discuss the aeromedical support enhancement measures by analyzing the disease spectrum and the aeromedical characteristics of temporarily grounded flying personnel.Methods:A retrospective analysis was conducted on the clinical data of 244 flying personnel who received medical treatment at the Southern Theater Air Force Hospital from November 2011 to March 2023 and were temporarily grounded in aeromedical assessment. The flying personnel were grouped by aircraft types (fighter, trans-bomber, helicopter) and flying hours (<2 000 h and ≥2 000 h), and the spectrum of temporarily unqualified flight diseases were statistically analyzed. The disease distributions of flying personnel in different aircraft types and flying hours were compared.Results:Among the 244 flying personnel (389 person-time) who were identified as temporarily grounded by aeromedical assessment, the major specialties involved were surgery (52.5%), internal medicine (24.6%) and neuropsychiatry (14.3%). The top 10 diseases leading to temporarily grounded were cervical and lumbar spine diseases, anxiety-depression, knee joint injury (surgical treatment), anal fistula (surgical treatment), sleep disorders, joint and soft tissue injuries, hypertension, ureteral stones, achilles tendon rupture and fracture (conservative treatment). There was a significant difference in the proportion of flying personnel temporarily grounded due to anxiety-depression among different aircraft types ( P=0.014). There were no significant differences in other diseases among flying personnel in different aircraft types (all P>0.05). The proportion of temporarily grounded flying personnel due to knee joint injury in flying hours <2 000 h was higher than that in flying hours ≥2 000 h, and the difference was significant ( χ2=4.47, P=0.035). Among the 71 flying personnel who underwent repeated ground observation, 28 were identified as qualified, 22 were grounded and 21 were still temporarily grounded. Conclusions:The proportion of flying personnel temporarily grounded due to diseases is relatively high. Accurate diagnosis and treatment of diseases and aeromedical assessment are important links to promote the early return of flying personnel.

Objective:To discuss the aeromedical support enhancement measures by analyzing the disease spectrum and the aeromedical characteristics of temporarily grounded flying personnel.Methods:A retrospective analysis was conducted on the clinical data of 244 flying personnel who received medical treatment at the Southern Theater Air Force Hospital from November 2011 to March 2023 and were temporarily grounded in aeromedical assessment. The flying personnel were grouped by aircraft types (fighter, trans-bomber, helicopter) and flying hours (<2 000 h and ≥2 000 h), and the spectrum of temporarily unqualified flight diseases were statistically analyzed. The disease distributions of flying personnel in different aircraft types and flying hours were compared.Results:Among the 244 flying personnel (389 person-time) who were identified as temporarily grounded by aeromedical assessment, the major specialties involved were surgery (52.5%), internal medicine (24.6%) and neuropsychiatry (14.3%). The top 10 diseases leading to temporarily grounded were cervical and lumbar spine diseases, anxiety-depression, knee joint injury (surgical treatment), anal fistula (surgical treatment), sleep disorders, joint and soft tissue injuries, hypertension, ureteral stones, achilles tendon rupture and fracture (conservative treatment). There was a significant difference in the proportion of flying personnel temporarily grounded due to anxiety-depression among different aircraft types ( P=0.014). There were no significant differences in other diseases among flying personnel in different aircraft types (all P>0.05). The proportion of temporarily grounded flying personnel due to knee joint injury in flying hours <2 000 h was higher than that in flying hours ≥2 000 h, and the difference was significant ( χ2=4.47, P=0.035). Among the 71 flying personnel who underwent repeated ground observation, 28 were identified as qualified, 22 were grounded and 21 were still temporarily grounded. Conclusions:The proportion of flying personnel temporarily grounded due to diseases is relatively high. Accurate diagnosis and treatment of diseases and aeromedical assessment are important links to promote the early return of flying personnel.

Objective:To evaluate the effect of intrathecal insulin-like growth factor-1 (IGF-1) on chemotherapy-induced neuropathic pain (NP) in mice.Methods:Forty clean-grade healthy male C57 mice, aged 7-9 weeks, weighing 22-24 g, were divided into 4 groups ( n=10 each) using a random number table method: control group (group C), chemotherapy-induced NP group (group CIPN), low-dose IGF-1 group (group I1) and high-dose IGF-1 group (group I2). In CIPN, I1 and I2 groups, oxaliplatin 5 mg/kg was intraperitoneally injected for 5 consecutive days to establish chemotherapy-induced NP model.Normal saline 0.2 ml was given in group C. After measurement of the pain threshold at 10 days after establishment of the model, IGF-1 0.5 and 1.0 μg were intrathecally injected in group I1 and group I2, respectively.Normal saline 5 μl was intrathecally injected in C and CINP groups.Mechanical withdrawal threshold (MWT) was measured at 3, 5, 8, 10, 11, 13 and 15 days after establishment of the model.After measurement of the pain threshold at 15 days after establishment of the model, the expression of spinal IGF-1, IGF-1receptor (IGF-1R), interleukin (IL)-17A, IL-1β and tumor necrosis factor (TNF)-α was detected, and IGF-1 positive cells were counted using immunofluorescence. Results:Compared with group C, MWT was significantly decreased, the expression of spinal IGF-1 was down-regulated, the count of IGF-1 positive cells was decreased, and expression of IL-17A, IL-1β and TNF-α was up-regulated at 3-25 days after establishment of the model in CINP, I1 and I2 groups ( P<0.05). Compared with group CIPN, MWT was significantly increased at 15 days after establishment of the model in group I1, and MWT was increased, the expression of spinal IGF-1 was up-regulated, the count of IGF-1 positive cells was increased, and expression of IL-17A, IL-1β and TNF-α was down-regulated at 13 and 15 days after establishment of the model in group I2 ( P<0.05). Compared with group I1, the count of IGF-1 positive cells in spinal dorsal horn was increased in group I2 ( P<0.05). There was no significant difference in the expression of spinal IGF-1R among the 4 groups ( P>0.05). Conclusion:Intrathecal IGF-1 can alleviate chemotherapy-induced NP, and the mechanism may be related to inhibiting the inflammatory responses in spinal cord of mice.