1.Mendel randomized analysis of the relationship between sleep disorders and coronary heart disease risk
Yangyang CUI ; Linqin DU ; Lijuan XIONG ; Qinglu JIANG ; Lang ZENG ; Shikang LI ; Xuefeng DING ; Zheng ZHOU ; Yonghong ZHANG ; Rongchuan YUE
China Modern Doctor 2025;63(23):6-9,18
Objective To investigate the relationship between sleep disorders and coronary heart disease through big data combined with Mendelian randomization analysis.Methods Data from 2005 to 2018 National Health and Nutrition Examination Survey in the United States were utilized.Logistic regression analysis was employed to evaluate the association between sleep disorders and coronary heart disease,while analyzing relevant influencing factors.A two-sample Mendelian randomization approach was implemented using Genome-Wide Association Studies to establish causal relationships.Results Logistic regression analysis demonstrated a significant association between sleep disorders and coronary heart disease(P＜0.001),with the neutrophil-to-lymphocyte ratio serving as a mediating factor in this relationship(P＜0.001).Mendelian randomization analysis revealed a positive correlation between sleep disorders and coronary heart disease(OR=1.030,95％CI:1.01-1.04).Conclusion Sleep disorders can increase the risk of coronary heart disease by activating inflammatory factors.
2.Mendel randomized analysis of the relationship between sleep disorders and coronary heart disease risk
Yangyang CUI ; Linqin DU ; Lijuan XIONG ; Qinglu JIANG ; Lang ZENG ; Shikang LI ; Xuefeng DING ; Zheng ZHOU ; Yonghong ZHANG ; Rongchuan YUE
China Modern Doctor 2025;63(23):6-9,18
Objective To investigate the relationship between sleep disorders and coronary heart disease through big data combined with Mendelian randomization analysis.Methods Data from 2005 to 2018 National Health and Nutrition Examination Survey in the United States were utilized.Logistic regression analysis was employed to evaluate the association between sleep disorders and coronary heart disease,while analyzing relevant influencing factors.A two-sample Mendelian randomization approach was implemented using Genome-Wide Association Studies to establish causal relationships.Results Logistic regression analysis demonstrated a significant association between sleep disorders and coronary heart disease(P＜0.001),with the neutrophil-to-lymphocyte ratio serving as a mediating factor in this relationship(P＜0.001).Mendelian randomization analysis revealed a positive correlation between sleep disorders and coronary heart disease(OR=1.030,95％CI:1.01-1.04).Conclusion Sleep disorders can increase the risk of coronary heart disease by activating inflammatory factors.
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