Objective:To explore the longitudinal relationship between adolescents' future self-continuity and depression, providing insights into their future development.Methods:A total of 419 adolescents from a school in Shandong Province were selected, and two followed-up surveys were conducted at 6-month intervals in April (T1) and October (T2) of 2023 using the future self-continuity questionnaire and Beck depression inventory-Ⅱ. Cross-lagged analysis was performed using Mplus 8.0.Results:The scores of future self-continuity were 36.01±8.69 at baseline (T1) and 35.89±9.92 after six months (T2), while the scores of depression were 2.00(0, 14.00) and 1.00(0, 9.00), respectively. There was a negative correlation between future self-continuity and depression at both time points (T1: r=-0.195, T2: r=-0.239, both P<0.01). Adolescents' future self-continuity could predict depression six months later ( β=-0.098, P<0.01), and depression also could predict the level of future self-continuity six months later ( β=-0.114, P<0.01). Conclusion:There is an interactively influence effect between adolescents' future self-continuity and depression.While enhancing adolescents' future self-continuity level to alleviate depression, attention should also be paid attention to the impact of depression on their future self-continuity, which can help adolescents overcome the interference of depressive emotions and grow into a better future self.

Objective:To explore the longitudinal relationship between adolescents' future self-continuity and depression, providing insights into their future development.Methods:A total of 419 adolescents from a school in Shandong Province were selected, and two followed-up surveys were conducted at 6-month intervals in April (T1) and October (T2) of 2023 using the future self-continuity questionnaire and Beck depression inventory-Ⅱ. Cross-lagged analysis was performed using Mplus 8.0.Results:The scores of future self-continuity were 36.01±8.69 at baseline (T1) and 35.89±9.92 after six months (T2), while the scores of depression were 2.00(0, 14.00) and 1.00(0, 9.00), respectively. There was a negative correlation between future self-continuity and depression at both time points (T1: r=-0.195, T2: r=-0.239, both P<0.01). Adolescents' future self-continuity could predict depression six months later ( β=-0.098, P<0.01), and depression also could predict the level of future self-continuity six months later ( β=-0.114, P<0.01). Conclusion:There is an interactively influence effect between adolescents' future self-continuity and depression.While enhancing adolescents' future self-continuity level to alleviate depression, attention should also be paid attention to the impact of depression on their future self-continuity, which can help adolescents overcome the interference of depressive emotions and grow into a better future self.

Ferroptosis is closely associated with the progression of various diseases.There are a series of anti-ferroptosis systems in the cell,the main function of which is to eliminate lipid peroxides and inhibit the occurrence of ferropto-sis.Ubiquitination is a crucial type of post-translational protein modification which can influence the degradation,intracellular localization,or function of substrate proteins.Ubiquitination modification plays an important role in regulating key proteins in-volved in ferroptosis pathways,such as SLC7A11,GPX4,FSP1,iron metabolism-related proteins,and other critical proteins in ferroptosis pathways.This review aims to summarize the research progress on ubiquitination modification of these key proteins in ferroptosis pathways,thereby elucidating the specific role of ubiquitination in ferroptosis pathways.

Stenotrophomonas maltophilia.At the same time 136 strains of fungi were isolated.Candida albicans was the most predominant accounted for 60.3%.50.7% Strains of K.pneumoniae and 75.7% strains of E.coli produced ESBLs.The resistance rates of all K.pneumoniae and E.coli to ?lactams were above 50%.All isolates of Enterobacteriaceae were sensitive to imipenem or meropenem.The activity of antibacterial agents against P.aeruginosa was coming down. CONCLUSIONS K.pneumoniae and E.coli are the major pathogens in senile patients with lower respiratory tract infection.Increasing of nonfermenters and fungi as an infection should bring great concern.

OBJECTIVE To explore the pathogenesis of Ureaplasma urealyticum(Uu)and Mycoplasma hominis(Mh)in urogenital tract infection and their susceptibility to antibiotics.METHODS Mycoplasma culture was carried out with the samples of 336 cases and then the susceptibility to 9 kinds of antibiotics was detected on positive samples.RESULTS From 336 cases 177 were infected with mycoplasma,the total positive rate was 52.7%,the positive rates of Uu,Mh and their mixed infection were 40.5%,2.4% and 9.8%,respectively.The positive rate of female was higher than of male(P

OBJECTIVE To study the clinical species distribution and drug resistance of Enterococcus.METHODS We had collected 201 isolates of Enterococcus by cultured in normal methods in our hospital from July 2005 to June 2008,and analyzed the characteristics of species distribution,drugsensitive test,drug resistance of high concentration aminoglycoside antibiotics and measured the ?-lactamase.RESULTS There are 106 E.faecalis strains(52.7%),76 E.faecium strains(37.8%) and 19 the other Enterococcus strains(9.5%).There were 102 Enerococcus strains separated from urine and 46 separated from sputamentum.The drug resistance rate of Enterococcus faecalis to erythromycin,tetracycline,rifampin and ciprofloxacin were more than 75.0% and the resistance rate of E.faecium to penicillin,ampicillin,erythromycin,rifampin,ciprofloxacin and nitrofurantoin were more than 93.0%;the total resistance rate of Enterococcus to vancomycin and teicoplanin were 14.4% and 10.4%,respectively.The number of the isolates resistant to high concentration aminoglycoside antibiotics was 151(75.1%);Enterococcus with positive ?-lactamase were 74(36.8%).CONCLUSIONS The infection in urinary system and respiratory system were mainly caused by E.faecalis and E.faeciumwith multidrug resistance.

OBJECTIVE To study the isolation rate,distribution characteristics and antimicrobial resistance of Acinetobacter baumannii infection.METHODS Surveillance data of A.baumannii infection,distribution and resistance rates to 12 kinds of antibiotics in our hospital for 3 years were analyzed.RESULTS During the 3-year infection surveillance,194 strains of A.baumannii were isolated in our hospital.The isolation rate was 7.8% in 2006,though 2.4% in 2004.Eighty strains(41.2%) of A.baumannii were from intensive care unit;95 strains were from over 60-year-old sufferers;compared with 2004 and 2005,the resistance rates of A.baumannii in 2006 to 12 kinds of antibiotics were increasing at different degree.The antibacterial susceptibility to imipenem/meropenem was the highest.CONCLUSIONS The isolation rate of A.baumannii and antimicrobial resistance rate are increasing year by year.The A.baumannii strains shows obvious multiple antibacterial resistance.We must keep monitoring of A.baumannii infection and drug-resistant changes in order to prevent nosocomial infections.