Due to its synergistic effects and reduced side effects, combination therapy has become an important strategy for treating complex diseases. In traditional Chinese medicine (TCM), the "monarch, minister, assistant, envoy" compatibilities theory provides a systematic framework for drug compatibility and has guided the formation of a large number of classic formulas. However, due to the complex compositions and diverse mechanisms of action of TCM, it is difficult to comprehensively reveal its potential synergistic patterns using traditional methods. Synergistic prediction based on molecular compatibility theory provides new ideas for identifying combinations of active compounds in TCM. Compared to resource-intensive traditional experimental methods, artificial intelligence possesses the ability to mine synergistic patterns from multi-omics and structural data, providing an efficient means for modeling and optimizing TCM combinations. This paper systematically reviews the application progress of AI in the synergistic prediction of TCM active compounds and explores the challenges and prospects of its application in modeling combination relationships, thereby contributing to the modernization of TCM theory and methodological innovation.
Artificial Intelligence ; Medicine, Chinese Traditional/methods* ; Drugs, Chinese Herbal/pharmacology* ; Humans ; Drug Synergism

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis-induced cell lysis and necrosis lead to the passive release of mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) into circulation. These DNAs bind to pattern recognition receptor (PRR), triggering excessive inflammatory cytokines production and increasing mortality. Three prime repair exonuclease 1 (TREX1) is a 3' to 5' exonuclease that rapidly degrades single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) by cleaving phosphodiester bonds. This process can prevent the accumulation of damaged DNA in the cytoplasm, thereby averting abnormal inflammation and pathological immune responses. TREX1 thus plays a significant role in regulating DNA-related damage caused by sepsis. However, the role and underlying mechanisms of TREX1 in sepsis have not been thoroughly discussed. This review aims to elucidate the structure and function of TREX1 and its mediated immune regulatory mechanisms, with the hope of clarifying the potential role of TREX1 in the field of sepsis.

?? [Abstract]? Objective? To explore the correlation between walking gait characteristics and fall fear in hemiplegic patients with acute ischemic stroke. Methods? 189 patients with hemiplegia after acute ischemic stroke treated in the First Affiliated Hospital of Zhengzhou University from March 2016 to March 2018 were selected as the research subjects. The patients were investigated by General Data Questionnaire, Single Item Fall Fear Assessment and Modified Fall Efficacy Scale(MFES). The gait parameters of patients were measured by gait analyzer to detect and analyze the correlation between gait characteristics and fall fear in hemiplegic patients with acute ischemic stroke. Results? Among 189 patients with hemiplegia after acute ischemic stroke, 123 (65.08%) were fearful of falling and 66 (34.92%) were not fearful of falling. The average score of items in Single Item Fall Fear Assessment in the patients with fear of falling were (7.64±1.63) and those without fear of falling were (9.01±1.33), the difference between the two groups was statistically significan(t P＜0.05). The step speed, step frequency, step length and standing phase in the fear of falling group were lower than those in the non-fear of falling group, and the step time and swing phase were higher than those in the non-fear of falling group with statistical difference(P＜0.05). Pearson correlation analysis showed that the step speed, step frequency, step length and standing phase were positively correlated with the MFES score(P＜0.05), and the step time and swing phase were negatively correlated with the MFES score (P＜0.05). Conclusions? Most of the hemiplegic patients with acute stroke have the fear of falling, and those who are afraid of falling are more likely to have abnormal gait, which indicates that those who are afraid of falling are more likely to fall, and need the attention of family members and medical staff.

BACKGROUND: Stromal cell-derived factor 1 (SDF1), a potential inhibitor of infection by lymphophilic HIV-1 strains, can help to block the pathway of HIV-1 invasion into the human body.OBJECTIVE: Genotype and polymorphism of SDF1-3 'A allele associated with HIV-1 infection were investigated in She Ethnic Group in the south of China so as explore the possible causes of uninfection by HIV-1 strains among this population.DESIGN: Single sample study.SETTING: Department of Biochemistry and Molecular Biology, Gannan Medical College.PARTICIPANTS: Totally 186 She Ethnic subjects without HIV-1 infection collected randomly from those whose three generations belonged to She Ethnic Group, and inhabited in Qianshan County of Jiangxi Province,Ningde area of Fujian Province and Jingning She County of Zhejiang Province, from January to December 1995.METHODS: The whole blood samples from 186 She Ethnic subjects were collected randomly, and then their genomic DNA samples were extracted respectively. Allelic polymorphism was examined by the polymerase chain reaction and restriction-fragment-length polymorphisms (PCR-RFLP).MAIN OUTCOME MEASURES: The distribution of SDF1-3'A allele in She Ethnic Group in the south of China.RESULTS: The data of 186 She Ethnic subjects entered the result analysis without any loss in the midway. The frequency of SDF1-3 'A allele in She Ethnic Group samples was 19.6%, and the allelic distribution of the gene was in accordance with Hardy-Weinberg equilibrium. No difference was found between male and female individuals.CONCLUSION: The frequency of SDF1-3 'A allele of She Ethnic Group in the south of China was similar to that of Dai Nationality in Yunnan.Based on its slow-down effect on clinical course of AIDS, the mutation of SDF1-3'A is significant in the prevention and treatment of AIDS in She Ethnic Group in the south of China.

This article analyzes the characteristics and present situation of informatized hospital to explore the management mode and reform of medical engineering,and thus lays substantial foundation for the development of informatized hospital.