[This corrects the article DOI: 10.1016/j.apsb.2021.08.008.].

Substantial progress in the use of chemo-photodynamic nano-drug delivery systems (nano-DDS) for the treatment of the malignant breast cancer has been achieved. The inability to customize precise nanostructures, however, has limited the therapeutic efficacy of the prepared nano-DDS to date. Here, we report a structurally defined tandem-responsive chemo-photosensitive co-nanoassembly to eliminate primary breast tumor and prevent lung metastasis. This both-in-one co-nanoassembly is prepared by assembling a biocompatible photosensitive derivative (pheophorbide-diphenylalanine peptide, PPA-DA) with a hypoxia-activated camptothecin (CPT) prodrug [(4-nitrophenyl) formate camptothecin, N-CPT]. According to computational simulations, the co-assembly nanostructure is not the classical core-shell type, but consists of many small microphase regions. Upon exposure to a 660 nm laser, PPA-DA induce high levels of ROS production to effectively achieve the apoptosis of normoxic cancer cells. Subsequently, the hypoxia-activated N-CPT and CPT spatially penetrate deep into the hypoxic region of the tumor and suppress hypoxia-induced tumor metastasis. Benefiting from the rational design of the chemo-photodynamic both-in-one nano-DDS, these nanomedicines exhibit a promising potential in the inhibition of difficult-to-treat breast tumor metastasis in patients with breast cancer.

Clinical symptoms with serum theoph ylline level above normal therapeutical range were analysed in 32 case. Methods: Theophylline 20μgmL-1 invserum was defined as the upper limit of normal therapeutical range. The case records with serum theo phylline concentraed ≥20μgmL-1 were selected from 324 cases, analyse d in combination with clinical symptoms. Results: Patients with serum theophylline concentration ≥20 μgmL-1 showed toxic reacti ons involving cardiovasucular, digestive, and nervous systems. One third of them took simultaneously other drugs which could decrease the metabolism of theophyl line. Conclusion: In order to prevent and diagnose toxicr eactions effectively, it's necessary to monitor the patients'serum theophylline level.

Objective:To check if antibacterials were rational in clinical use.Methods:143 inpatients between June and December 1998 were enrolled for retrospective analysis of drug administration.Results:132 cases took an tibacterial drugs accounting for 92.3％,among them 69 cases (52.3％) for treatment and 63 cases (47.7％) for preventive purposes.From the said patients only 16 samples were collected and sent for bacterial culture,its positive rate being 31.5 ％.Antibacterials taken covered 43 kinds of 10 categories,altogether 1573 drug-days.The rate of the unreasonable application was 39.4 ％ (52/132 cases) or 42.5 ％ (668/1573 drug-days).Medication for wrong indications or for a longer period than neccessity could be the main problem.Conclusion:In order to upgrade the diagnostic and therapeutic level,medical professionals should have knowledge of and be familiar with antibacterials and use them in a reasonable way in combination with bacterial culture and drug sensitivity test,if possible.

86 drugs could cause hematuria on reference review of 1980-1998.Analgesic and anti-irflammnatory agents were the culprit in both kinds (22) and cases (230),and Ganmaotong was the first among them.The causes of hernaturia were discussed.Rational use of drugs was suggested in order to reduce the drug-induced renal damage.

Objective:To check if antibacterials were rational in clinical use.Methods:143 inpatients between June and December 1998 were enrolled for retrospective analysis of drug administration.Results:132 cases took an tibacterial drugs accounting for 92.3％,among them 69 cases (52.3％) for treatment and 63 cases (47.7％) for preventive purposes.From the said patients only 16 samples were collected and sent for bacterial culture,its positive rate being 31.5 ％.Antibacterials taken covered 43 kinds of 10 categories,altogether 1573 drug-days.The rate of the unreasonable application was 39.4 ％ (52/132 cases) or 42.5 ％ (668/1573 drug-days).Medication for wrong indications or for a longer period than neccessity could be the main problem.Conclusion:In order to upgrade the diagnostic and therapeutic level,medical professionals should have knowledge of and be familiar with antibacterials and use them in a reasonable way in combination with bacterial culture and drug sensitivity test,if possible.

86 drugs could cause hematuria on reference review of 1980-1998.Analgesic and anti-irflammnatory agents were the culprit in both kinds (22) and cases (230),and Ganmaotong was the first among them.The causes of hernaturia were discussed.Rational use of drugs was suggested in order to reduce the drug-induced renal damage.