Objective:To establish a method for the determination of eight N-nitrosamines (N-nitrosodimethylamine, N-nitrosodimethylamine, N-nitrosomethylmethylamine, N-nitrosodibutylamine, N-nitrosopropylamine, N-nitrosomorpholine, N-nitrosodianiline and N-nitrosopiperidine) in the air of workplace by gas chromatography-tandem mass spectrometry (GC-MS/MS) .Methods:From January to August 2023, eight N-nitrosamines in the air of workplace were collected by ThermoSorb/N column, eluted with 4 ml methanol-dichloromethane (1∶1 volume ratio), separated by VF-624 ms capillary column, detected by multiple reaction monitoring mode and quantified by external standard method. The detection limit and precision of the method were also analyzed.Results:The linear range of the method for the determination of eight N-nitrosamines was 1.0-20.0 μg/L, the correlation coefficient was 0.9993-0.9999, the detection limit was 0.051-0.132 μg/L, and the minimum quantitative concentration was 0.030-0.078 μg/m 3 (calculated by collecting 22.5 L of air sample and eluting with 4.0 ml stripping liquid). The within-run precisions were 2.05%-6.89% and the between-run precisions were 2.41%-8.26%. The desorption rates were 67.20%-102.60%. The sample can be kept at least 7 days at 4 ℃. Conclusion:GC-MS/MS method for the determination of eight N-nitrosamines in workplace air has high sensitivity and good precision, and can accurately determine the content of eight N-nitrosamines in workplace air.

Objective:To establish a method for the determination of eight N-nitrosamines (N-nitrosodimethylamine, N-nitrosodimethylamine, N-nitrosomethylmethylamine, N-nitrosodibutylamine, N-nitrosopropylamine, N-nitrosomorpholine, N-nitrosodianiline and N-nitrosopiperidine) in the air of workplace by gas chromatography-tandem mass spectrometry (GC-MS/MS) .Methods:From January to August 2023, eight N-nitrosamines in the air of workplace were collected by ThermoSorb/N column, eluted with 4 ml methanol-dichloromethane (1∶1 volume ratio), separated by VF-624 ms capillary column, detected by multiple reaction monitoring mode and quantified by external standard method. The detection limit and precision of the method were also analyzed.Results:The linear range of the method for the determination of eight N-nitrosamines was 1.0-20.0 μg/L, the correlation coefficient was 0.9993-0.9999, the detection limit was 0.051-0.132 μg/L, and the minimum quantitative concentration was 0.030-0.078 μg/m 3 (calculated by collecting 22.5 L of air sample and eluting with 4.0 ml stripping liquid). The within-run precisions were 2.05%-6.89% and the between-run precisions were 2.41%-8.26%. The desorption rates were 67.20%-102.60%. The sample can be kept at least 7 days at 4 ℃. Conclusion:GC-MS/MS method for the determination of eight N-nitrosamines in workplace air has high sensitivity and good precision, and can accurately determine the content of eight N-nitrosamines in workplace air.

Objective:To evaluate the effectiveness of an advance care planning (ACP) education intervention based on the respecting choices model for patients with advanced cancer.Methods:A total of 78 advanced cancer patients admitted to Songshan Lake Central Hospital of Dongguan City from April 2022 to September 2023 were selected by convenient sampling and divided randomly into an observation group and a control group (39 patients each). The control group received standard care, while the observation group received the ACP education intervention in addition to standard care, based on the respecting choices model. The ACP Readiness Scale (ACPRS-C), the Palliative Care Attitudes Scale (PCAS-9), and the Functional Assessment of Cancer Therapy-General (FACT-G) scale were used to assess both groups at baseline, immediately post-intervention, and four weeks after the intervention.Results:Post-intervention scores on the ACPRS-C, PCAS-9, and FACT-G were significantly higher in the observation group compared to the control group. Group effects, time effects, and interaction effects were observed ( P<0.01) . Conclusions:The ACP education intervention based on the respecting choices model effectively improves ACP readiness, palliative care attitudes, and quality of life in patients with advanced cancer.

Objective:To evaluate the effectiveness of an advance care planning (ACP) education intervention based on the respecting choices model for patients with advanced cancer.Methods:A total of 78 advanced cancer patients admitted to Songshan Lake Central Hospital of Dongguan City from April 2022 to September 2023 were selected by convenient sampling and divided randomly into an observation group and a control group (39 patients each). The control group received standard care, while the observation group received the ACP education intervention in addition to standard care, based on the respecting choices model. The ACP Readiness Scale (ACPRS-C), the Palliative Care Attitudes Scale (PCAS-9), and the Functional Assessment of Cancer Therapy-General (FACT-G) scale were used to assess both groups at baseline, immediately post-intervention, and four weeks after the intervention.Results:Post-intervention scores on the ACPRS-C, PCAS-9, and FACT-G were significantly higher in the observation group compared to the control group. Group effects, time effects, and interaction effects were observed ( P<0.01) . Conclusions:The ACP education intervention based on the respecting choices model effectively improves ACP readiness, palliative care attitudes, and quality of life in patients with advanced cancer.