Objective: The phase 2, open-label, randomized, 3-arm study (NCT03776812) found that intermittently dosed relacorilant + nab-paclitaxel improved progression-free survival, duration of response, and overall survival compared with nab-paclitaxel monotherapy with minimal additional toxicity. This study analyzed the cost-effectiveness of intermittent relacorilant + nab-paclitaxel (IN), continuous relacorilant + nab-paclitaxel (CN) and nabpaclitaxel monotherapy (N) from the payer’s perspective over a 5-year time horizon. Methods: The health outcome is expressed in quality-adjusted life years (QALYs). IN, CN and N were evaluated using QALYs and incremental cost-effectiveness ratio (ICER). The data for this model come from the NCT03776812 trial and other published literature. The impact of the variables is studied using a one-way deterministic sensitivity analysis and a probabilistic sensitivity analysis based on a second-order Monte Carlo simulation. Results: N was the least costly strategy, at $ 4606.05, followed by IN ($22,597.75) and CN ($44,276.86). Based on a willingness-to-pay threshold of $100,000/QALY, IN was costeffective compared with N, with an ICER of $21,418.69 per QALY gained for N, whereas CN was ruled out by extended dominance (less effective, more costly), compared with N. The incremental benefits of IN compared to CN and N were 0.72 QALYs and 0.84 QALYs. Conclusion From a US health care system perspective, IN may be cost-effective compared to CN for patients with recurrent platinum-resistant ovarian cancer, and IN is also better than CN and N in terms of efficacy. Therefore, IN is a high-quality regimen for clinicians to treat patients with recurrent platinum-resistant ovarian cancer.

To investigate the current situation and demand for specialized development of allergy nursing in 88 hospitals in Guangdong Province, as well as to provide evidence for the management of allergy nursing. From August to December 2023, a cross-sectional study was conducted to analyze the core managers of allergy nursing-related work in eighty-eight hospitals in Guangdong Province supported by the Allergy Nursing Branch of the Guangdong Nurses Association and the Nursing Group of the Allergy Branch of the Guangdong Medical Association. An online survey was conducted using the Delphi method to compile a questionnaire on the current status and demand for specialized development of allergy nursing in Guangdong Province. Chi-square tests and Fisher′s exact probability method were used to analyze the differences in the current status of specialty technology applications and the development and demand of specialized nursing between hospitals with or without allergy specialty departments. The results showed that among the eighty-eight hospitals in the nineteen prefecture-level cities surveyed in Guangdong Province, 17 hospitals (19%) had established allergy specialty departments, all of which were top-tier tertiary hospitals. The establishment duration [ M ( Q1, Q3)] was 3 (1, 10) years. The implementation rates of skin prick test (94%, 16/17), in-vitro examination (82%, 14/17), nasal endoscopy (82%, 14/17), subcutaneous specific immunotherapy (82%, 14/17), multidisciplinary consultation (65%, 11/17), fractional exhaled nitric oxide detection (47%, 8/17), skin patch test (41%, 7/17), and autologous serum skin test (35%, 6/17) in hospitals with allergy department were higher than those in hospitals without allergy department [59%, 42/71 ( χ 2= 7.462, P=0.006)], [54%, 38/71 ( χ 2= 4.717, P=0.030)], [51%, 36/71 ( χ 2= 5.599, P=0.018)], [34%, 24/71 ( χ 2= 13.177, P<0.001)], [24%, 17/71 ( χ 2= 10.505, P=0.001)], [24%, 17/71 ( χ 2= 5.540, P=0.019)], [11%, 8/71 (Fisher′s exact test, P=0.008)], [11%, 8/71 (Fisher′s exact test, P=0.025)]. In the development plan of allergy nursing in the next two years, hospitals that had set up allergy departments had a higher proportion in adding nurses (82%, 14/17, χ 2= 13.177, P<0.001), formulating specialized nurse training plans (71%, 12/17, χ 2= 3.980, P=0.046), formulating group standards or clinical guidelines (41%, 7/17, Fisher′s exact test, P=0.046), and formulating assessment standards (53%, 9/17, Fisher′s exact test, P=0.002). The demand for all aspects of allergy specialty nursing knowledge and skills accounted for more than 50%, and it was not related to whether the hospital set up an allergy department. In conclusion, the specialized development of allergy nursing in Guangdong province is still in its early stages, and there is a great demand for improving knowledge and skills in allergy. Further standardization of specialty construction is needed, along with the training of allergic nurses, to promote the comprehensive development of allergic reaction nursing specialties from point to area.

To investigate the current situation and demand for specialized development of allergy nursing in 88 hospitals in Guangdong Province, as well as to provide evidence for the management of allergy nursing. From August to December 2023, a cross-sectional study was conducted to analyze the core managers of allergy nursing-related work in eighty-eight hospitals in Guangdong Province supported by the Allergy Nursing Branch of the Guangdong Nurses Association and the Nursing Group of the Allergy Branch of the Guangdong Medical Association. An online survey was conducted using the Delphi method to compile a questionnaire on the current status and demand for specialized development of allergy nursing in Guangdong Province. Chi-square tests and Fisher′s exact probability method were used to analyze the differences in the current status of specialty technology applications and the development and demand of specialized nursing between hospitals with or without allergy specialty departments. The results showed that among the eighty-eight hospitals in the nineteen prefecture-level cities surveyed in Guangdong Province, 17 hospitals (19%) had established allergy specialty departments, all of which were top-tier tertiary hospitals. The establishment duration [ M ( Q1, Q3)] was 3 (1, 10) years. The implementation rates of skin prick test (94%, 16/17), in-vitro examination (82%, 14/17), nasal endoscopy (82%, 14/17), subcutaneous specific immunotherapy (82%, 14/17), multidisciplinary consultation (65%, 11/17), fractional exhaled nitric oxide detection (47%, 8/17), skin patch test (41%, 7/17), and autologous serum skin test (35%, 6/17) in hospitals with allergy department were higher than those in hospitals without allergy department [59%, 42/71 ( χ 2= 7.462, P=0.006)], [54%, 38/71 ( χ 2= 4.717, P=0.030)], [51%, 36/71 ( χ 2= 5.599, P=0.018)], [34%, 24/71 ( χ 2= 13.177, P<0.001)], [24%, 17/71 ( χ 2= 10.505, P=0.001)], [24%, 17/71 ( χ 2= 5.540, P=0.019)], [11%, 8/71 (Fisher′s exact test, P=0.008)], [11%, 8/71 (Fisher′s exact test, P=0.025)]. In the development plan of allergy nursing in the next two years, hospitals that had set up allergy departments had a higher proportion in adding nurses (82%, 14/17, χ 2= 13.177, P<0.001), formulating specialized nurse training plans (71%, 12/17, χ 2= 3.980, P=0.046), formulating group standards or clinical guidelines (41%, 7/17, Fisher′s exact test, P=0.046), and formulating assessment standards (53%, 9/17, Fisher′s exact test, P=0.002). The demand for all aspects of allergy specialty nursing knowledge and skills accounted for more than 50%, and it was not related to whether the hospital set up an allergy department. In conclusion, the specialized development of allergy nursing in Guangdong province is still in its early stages, and there is a great demand for improving knowledge and skills in allergy. Further standardization of specialty construction is needed, along with the training of allergic nurses, to promote the comprehensive development of allergic reaction nursing specialties from point to area.

Objective:To analyze the predictive effect of tumor deposit(TD) on the prognosis of yp-stage Ⅲ rectal cancer patients, and its effect on postoperative adjuvant chemotherapy benefit.Methods:Clinical data of 338 ypⅢ stage rectal cancer patients who received multidisciplinary treatment in Union Medical College Affiliated Hospital of Fujian Medical University from 2007 to 2017 were retrospectively analyzed. All patients were divided into the TD(-) group( n=301) and TD(+ ) group( n=37). Survival analysis was conducted by Kaplan- Meier method, log-rank test and univariate prognostic analysis. Multivariate prognostic analysis was performed by Cox’s regression model. Results:The 5-year overall survival(OS), progress-free survival(PFS), and distant metastasis-free survival(DMFS) in the TD(-) group were significantly higher than those in the TD(+ ) group(59.3% vs. 42.0%, P=0.001, 79.1% vs. 55.0%, P<0.001, 55.6% vs. 38.0%, P<0.001), whereas no significant difference was observed in local recurrence-free survival(LRFS) between two groups(96.7% vs. 85.5%, P=0.679). Univariate prognostic analysis revealed that the number of TD was not correlated with the prognosis of patients( P=0.923), and postoperative adjuvant chemotherapy exerted no significant effect on the prognosis of patients in two groups( P=0.103). In multivariate analysis, TD was associated with worse OS( HR=2.343, 95% CI: 1.257-4.363, P=0.007). Conclusions:For patients with ypⅢ stage rectal cancer undergoing multidisciplinary treatment, the prognosis of patients with TD is even worse. TD is an independent predictor for survival. No benefit can be obtained from postoperative adjuvant chemotherapy regardless of the presence or absence of TD.

OBJECTIVE To investigate the effects of 1,8-cineol on lung functions and mechanism in asthmatic guinea pigs. METHODS The guinea pig model was performed by intraperitoneal injection of the 0.5 ml Al(OH)_3 gel containing OVA 20 μg. The guinea pigs were constructed by immunization of intraperitoneal injection on the 0 day and the 7th day, and the experiment was performed on the 28th day. The effect of 1,8-cineol 10, 30 and 100 ml·kg~(-1) on the airway resistance(R_(aw)) and dynamic lung compliance (C_(dyn)) of asthmatic guinea pigs 1 h after challenge of OVA. The changes in leukocyte and different kinds of leukocyte in bronchoalveolar lavage fluid (BALF) after the challenge of OVA have been studied. The levels of eosinophil cationic protein (ECP), interleukin(IL)-4, IL-8 and tumor necrosis factor (TNF)-α in lungs of guinea pigs were determined using enzyme-linked immunosorbent assay (ELISA). The changes in R_(aw) and C_(dyn) of asthmatic guinea pigs were investigated 17 h after challenge of OVA and inhalated methacholine (MCh). The changes in leukocyte and different kinds of leukocyte in BALF after the challenge of OVA have been studied. The levels of ECP, IL-4, IL-8 and TNF-α in lungs of guinea pigs were determined using ELISA. RESULTS 1,8-Cineol inhibited increase in R_(aw) and decrease in C_(dyn) from 1 to 30 min after challenge of OVA in model group. The levels of ECP, IL-4 and TNF-α in asthmatic model group were higher than those in normal control group(P<0.05). The levels of ECP, IL-4 and TNF-α of 1,8-cineol 100 mg·kg~(-1) group were significantly lower than those in asthmatic model group (P<0.01). The level of IL-8 of asthmatic model group didn't have any significant difference from that of control group. 1,8-Cineol 100 mg·kg~(-1) could significantly decrease the numbers of leukocyte and the percent of eosinophils in BALF. Seventeen hours after challenge of OVA, R_(aw) and C_(dyn) of asthmatic model group were higher than these of control group (P<0.05, P<0.01); 1,8-cineol 100 mg·kg~(-1) significantly inhibited the increase in R_(aw), compared with model group (P<0.05); 1,8-cineol 10, 30 and 100 mg·kg~(-1) improved the decrease in C_(dyn) after MCh-induced in model group which were challenged by OVA after 17 h; 1,8-cineol 100 mg·kg~(-1) could significantly decrease the numbers of leukocyte and the percent of neutrophils, the levels of ECP, IL-8 and TNF-α compared with asthmatic group. The level of IL-4 in asthmatic model group didn't have any significant difference from that in normal control group. CONCLUSION In the course of early stage of asthma, 1,8-cineol inhibites the asthma by decreasing the number of eosinophils and down-regulating the activity of EPO. In the course of later stage of asthma, 1,8-cineol inhibits or improves the aggravation and lasting states of asthma which is directly coursed by neutrophils accumulating in the BALF that related to the increase in IL-8.

[Objective] To investigate the effects of the Sheng Jing Tang, one of tonyfing kidney and promoting blood circulation recipes,on female rats anovulatory due to testosterone and to study the mechanism of action of the recipe. [Methods] The rat models of anovulatory disease were established by injecting the immature female SD rat with testosterone and treated with TCM and herbs to observe estrous cycle level of sex hormone of blood and the change of pathological histology of ovary. [Results] Sheng Jing Tang could improve the level of sex hormone, contract the expanded oxarian vesicles obviously and increase the quantity of luteum. [Conclusions] Sheng Jing Tang had the effect of improving the syndromes of Polycystic Ovary, inducing ovulation and recovering the function of ovary.