Objective:To conduct a statistical analysis on the condition of patients with pneumoconiosis complicated with chronic pulmonary heart disease based on the Tei index, and to establish a relevant prediction model.Methods:In March 2022, a retrospective analysis of 226 patients diagnosed with pneumoconiosis in the Department of Occupational Disease of Yantai Yantaishan Hospital from January 2016 to January 2022 was conducted. The patients with pneumoconiosis complicated by pulmonary heart disease were included in the pulmonary heart disease group and others were included in the non-pulmonary heart disease group. logistic regression analysis was used to screen out the relevant factors and establish a risk prediction model. Hosmer-Lemeshow test was applied to determine the goodness of fit of the model, and the receiver operating characteristic (ROC) area under the curve (AUC) was used to evaluate the predictive effect of the model.Results:Among the 226 patients with pneumoconiosis, 58 patients had chronic pulmonary heart disease, accounting for 25.7% of the surveyed population. The logistic analysis showed that the course of disease, pneumoconiosis stage and Tei index were influencing factors of pneumoconiosis complicated with pulmonary heart disease ( P<0.05). A risk prediction model for pneumoconiosis patients complicated with pulmonary heart disease was developed: Z=6.253 X1+1.265 X2+1.423 X3+9.264, in which X1 was the stage of pneumoconiosis, X2 was the course of disease, and X3 was the Tei index. Hosmer-Lemeshow test was used to evaluate the goodness of fit of the risk prediction model for pneumoconiosis patients complicated with pulmonary heart disease, the results indicated that the prediction model was in good agreement with the actual situation (χ 2=11.59, P=0.254). The diagnostic ability of the model was evaluated by the ROC curve, and the results showed that its AUC was 0.897, the sensitivity was 0.947, and the specificity was 0.784. Conclusion:The course of disease, pneumoconiosis stage and Tei index are the influencing factors of pneumoconiosis complicated with pulmonary heart disease. The model constructed based on these factors has a good prediction effect, which can provide a basis for the early detection and intervention of pneumoconiosis complicated with pulmonary heart disease.

Objective:To conduct a statistical analysis on the condition of patients with pneumoconiosis complicated with chronic pulmonary heart disease based on the Tei index, and to establish a relevant prediction model.Methods:In March 2022, a retrospective analysis of 226 patients diagnosed with pneumoconiosis in the Department of Occupational Disease of Yantai Yantaishan Hospital from January 2016 to January 2022 was conducted. The patients with pneumoconiosis complicated by pulmonary heart disease were included in the pulmonary heart disease group and others were included in the non-pulmonary heart disease group. logistic regression analysis was used to screen out the relevant factors and establish a risk prediction model. Hosmer-Lemeshow test was applied to determine the goodness of fit of the model, and the receiver operating characteristic (ROC) area under the curve (AUC) was used to evaluate the predictive effect of the model.Results:Among the 226 patients with pneumoconiosis, 58 patients had chronic pulmonary heart disease, accounting for 25.7% of the surveyed population. The logistic analysis showed that the course of disease, pneumoconiosis stage and Tei index were influencing factors of pneumoconiosis complicated with pulmonary heart disease ( P<0.05). A risk prediction model for pneumoconiosis patients complicated with pulmonary heart disease was developed: Z=6.253 X1+1.265 X2+1.423 X3+9.264, in which X1 was the stage of pneumoconiosis, X2 was the course of disease, and X3 was the Tei index. Hosmer-Lemeshow test was used to evaluate the goodness of fit of the risk prediction model for pneumoconiosis patients complicated with pulmonary heart disease, the results indicated that the prediction model was in good agreement with the actual situation (χ 2=11.59, P=0.254). The diagnostic ability of the model was evaluated by the ROC curve, and the results showed that its AUC was 0.897, the sensitivity was 0.947, and the specificity was 0.784. Conclusion:The course of disease, pneumoconiosis stage and Tei index are the influencing factors of pneumoconiosis complicated with pulmonary heart disease. The model constructed based on these factors has a good prediction effect, which can provide a basis for the early detection and intervention of pneumoconiosis complicated with pulmonary heart disease.

Objective:To observe the effect of supplementing vacuum sealing drainage with hyperbaric oxygen in the short term treatment of diabetic foot ulcers.Methods:A total of 156 persons diagnosed with diabetic foot ulcers were randomly divided into a control group and a treatment group, each of 78. Both groups received life guidance and active treatment to lower blood sugar and lipids, as well as anti-infection treatment guided by bacterial cultures. Both groups′ wounds were debrided. The wound was then covered with foam, sealed, and negative pressure of -75 to -100mmHg was applied during 1 week of drainage. Two courses of this treatment were applied. In addition, the treatment group received hyperbaric oxygen daily during the two weeks. The exposure pressure was incrased to 0.25MPa over 15min with 100% oxygen. That was inhaled in two 30min sessions with a 10min interval. The pressure then decompressed at a constant rate for 25 minutes. Wound healing, hemorheology, wound granulation tissue staining and any changes in TGF-β1 were observed before as well as after 7 and 14 days of the treatment.Results:The average wound size and symptom score of both groups had improved significantly after the treatment, with the largest effect in the treatment group during the first week. Both groups′ hemorheology had improved significantly after one week, but the treatment group′s improvement was greater. After 2 weeks, however, there was no significant difference in the average hemorheologic indicators for either group compared with before the treatment. Hematoxylin-eosin staining of the wound tissues showed that there were many inflamed cells before the treatment, with relatively little fresh granulation tissue or new blood vessels. After one week of treatment much new granulation tissue was observed under the microscope in both groups, with no significant difference between them. One week later, there was still much granulation tissue in the control group, but slightly less in the treatment group. The ave-rage post-treatment TGF-β1 protein levels in the wound tissues of both groups were significantly higher than before the treatment, but after two weeks the average TGF-β1 protein level had decreased significantly in the treatment group compared with the control group.Conclusions:One week of hyperbaric oxygen treatment can effectively improve the hemorheology of persons with diabetic foot ulcers, promote the proliferation of granulation tissue and fibroblasts, and increase the level of TGF-β1 protein in the wound tissues. However, the effects of hyperbaric oxygen treatment weaken gradually with time.

Background: Classical swine fever virus (CSFV), the causative agent of classical swine fever (CFS), is a highly contagious disease that poses a serious threat to Chinese pig populations. Objectives: Many provinces of China, such as Shandong, Henan, Hebei, Heilongjiang, and Liaoning provinces, have reported epidemics of CSFV, while the references to the epidemic of CSFV in Yunnan province are rare. This study examined the epidemic characteristics of the CSFV in Yunnan province. Methods: In this study, 326 tissue samples were collected from different regions in Yunnan province from 2015 to 2021. A reverse transcription-polymerase chain reaction (RT-PCR), sequences analysis, and phylogenetic analysis were performed for the pathogenic detection and analysis of these 326 clinical specimens. Results: Approximately 3.37% (11/326) of specimens tested positive for the CSFV by RTPCR, which is lower than that of other regions of China. Sequence analysis of the partial E2 sequences of eleven CSFV strains showed that they shared 89.0–100.0% nucleotide (nt) and 95.0–100.0% amino acid (aa) homology, respectively. Phylogenetic analysis showed that these novel isolates belonged to the subgenotypes 2.1c and 2.1d, with subgenotype 2.1c being predominant. Conclusions The CSFV was sporadic in China’s Yunnan province from 2015 to 2021. Both 2.1c and 2.1d subgenotypes were found in this region, but 2.1c was dominant.

Objective To compare the clinical efficacy and safety of Hybrid knife versus triangular tip during peroral endoscopic myotomy(POEM) for patients with achalasia of cardia. Methods Data of patients with achalasia of cardia who received POEM in Nanfang Hospital, Southern Medical University from June 2012 to July 2014 were collected and divided into the Hybrid knife group ( using Hybrid knife) and triangular tip group ( using injection needle and triangular tip). Procedure-related parameters, symptom relief, and adverse events were compared between the two groups. Results A total of 57 patients were selected, including 25 patients in the Hybrid knife group and 32 in the triangular tip group. There were no significant differences on baseline characteristics between the two groups ( P＞0. 05). The mean procedure time was shorter in the Hybrid knife group than that in the triangular tip group (55. 3±17. 7 min VS 69. 5± 9. 4 min, P＝0. 038). The mean frequency of devices exchange was less in the Hybrid knife group than that in the triangular tip group (4. 5±1. 5 VS 10. 7±1. 7, P＝0. 000). No serious complications occurred during operation and periodical follow-up in both groups. At one-year follow-up, the treatment success rate was 92. 0%(23/25) in the Hybrid knife group and 96. 9%(31/32) in the triangular tip group (P＝0. 576). Conclusion Using Hybrid knife in POEM can shorten procedural time and achieve similar treatment success rate compared to triangular tip.

Objective To investigate the effect of hyperbaric oxygen (HBO) combined with drugs in the treatment of calcaneal fracture pain.Methods A total of 64 calcaneal fracture patients hospitalized from January,2016 to May 2017 were evenly divided into the experimental group and the control group,each consisting of 32 patients.The control group received conventional analgesic therapy and routine nursing (e.g.elevation of injured limbs,cold compress,drug analgesia,repercussion or relieving of swelling etc.),while the experimental group received HBO in addition to conventional analgesic therapy.NRS scores during the perioperative stage were observed and compared between the patients of the 2 groups.Results At admission into hospital and 2 hours after surgery,there was no statistical significance in the NRS scores for the experimental group,as compared with those of the control group (P ＞ 0.05).The highest,lowest and average Fin scores at rest for the experimental group 3 days after surgery were respectively 5.0 ± 1.5,1.7 ± 0.6 and 2.5 ± 1.0,while those of the control group were respectively 7.5 ± 1.2,3.2 ± 0.7 and 4.0 ± 0.8.The pain scores at motion for the experimental group 7 days after surgery were 3.2 ± 0.6,while those of the control group were 4.6 ± 0.8,with the former being obviously lower than the latter,and statistical significance could be seen when comparisons were made between them (P ＜ 0.01).Conclusions HBO combined with drugs in the treatment of calcaneal fracture could obviously alleviate pain,improve patient life quality and promote recovery after surgery.

Objective To investigate the effect of hyperbaric oxygen (HBO) combined with drugs in the treatment of calcaneal fracture pain.Methods A total of 64 calcaneal fracture patients hospitalized from January,2016 to May 2017 were evenly divided into the experimental group and the control group,each consisting of 32 patients.The control group received conventional analgesic therapy and routine nursing (e.g.elevation of injured limbs,cold compress,drug analgesia,repercussion or relieving of swelling etc.),while the experimental group received HBO in addition to conventional analgesic therapy.NRS scores during the perioperative stage were observed and compared between the patients of the 2 groups.Results At admission into hospital and 2 hours after surgery,there was no statistical significance in the NRS scores for the experimental group,as compared with those of the control group (P ＞ 0.05).The highest,lowest and average Fin scores at rest for the experimental group 3 days after surgery were respectively 5.0 ± 1.5,1.7 ± 0.6 and 2.5 ± 1.0,while those of the control group were respectively 7.5 ± 1.2,3.2 ± 0.7 and 4.0 ± 0.8.The pain scores at motion for the experimental group 7 days after surgery were 3.2 ± 0.6,while those of the control group were 4.6 ± 0.8,with the former being obviously lower than the latter,and statistical significance could be seen when comparisons were made between them (P ＜ 0.01).Conclusions HBO combined with drugs in the treatment of calcaneal fracture could obviously alleviate pain,improve patient life quality and promote recovery after surgery.

BACKGROUND/AIMS: In recent years, endoscopic submucosal tunnel dissection (ESTD) has gained popularity worldwide. The aim of this study was to evaluate the safety and efficacy of ESTD in treating upper gastrointestinal submucosal tumors (SMTs) in a large-volume endoscopic center. METHODS: Patients with SMTs were enrolled in this study between January 2012 and January 2015. Demographic data, clinical data, and treatment outcome were collected and analyzed. RESULTS: Seventy SMTs originating from the muscularis propria (MP) layer were identified in 69 patients. All patients successfully underwent the ESTD procedure. The mean procedure time was 49.0±29.5 minutes, and the mean tumor size was 18.7±7.2 mm. Among all lesions, the majority (70.0%) were located in the esophagus, 12.9% in the cardia, and 17.1% in the stomach. Complete resection was achieved in 67 lesions (95.7%). Perforation occurred in three patients (4.3%), who were treated by endoclips. Pneumothorax occurred in two patients (2.9%) and was successfully managed by thoracic drainage. During a median follow-up of 18.1 months, patients were free of local recurrence or distant metastasis. CONCLUSIONS: Our results demonstrated the feasibility and safety of ESTD in treating upper gastrointestinal SMTs originating from the MP layer. Large-scale comparative studies with other treatment methods should be conducted in the future.
Cardia ; Drainage ; Esophagus ; Follow-Up Studies ; Humans ; Neoplasm Metastasis ; Pneumothorax ; Recurrence ; Stomach ; Treatment Outcome

Objective To investigate the clinical effects of hyperbaric oxygen on the control of serum glucose and healing of incision in the patients with calcaneal fracture complicated with diabetes mellitus following surgery.Methods Sixty cases of calcaneal fracture complicated with diabetes mellitus hospitalized from August 2015 to August 2016 were designated as the HBO group and the control group,in accordance with different wards designated,and each group consisted of 30 cases.The patients in the control group were given conventional postsurgical treatment and nursing,such as elevation of the affected limb,control of blood glucose,repercussion and promotion of bone healing,while the patients in the HBO group received HBO therapy,in addition to conventional therapy and nursing.Serum glucose level and healing of incision 2 weeks after surgery were closely observed and compared between the patients of the 2 groups.Results There was no statistical significance in the level of fasting blood glucose and glycosylated hemoglobin for the patients of the HBO group on the first day after surgery,as compared with those of the control group (P ＞ 0.05).Fasting blood glucose levels of the HBO group on the third,seventh and tenth days after surgery were respectively (5.5 ± 1.1) mmol/L,(5.4 ± 1.2) mmol/L and (5.2 ± 1.2) mmol/L,while those of the control group were (7.6 ± 0.7) mmol/L,(7.4 ± 0.9) mmol/L and (7.5 ± 0.9) mmol/L respectively.Blood glucose levels 2 hours after meal for the HBO group were respectively (8.4 ± 1.1) mmol/L,(7.9 ± 1.2) mmol/L and (8.2 ± 1.2) mmol/L,while those for the control group were (10.5 ± 1.1) mmol/L,(10.4 ± 1.2) mmol/L and (10.9 ± 1.2) mmol/L respectively.Glycosylated hemoglobin level for the patients of the HBO group on the seventh day after surgery was(6.7 ±0.4)％,while that of the control group was (7.3 ±0.6)％,which was obviously higher than that of the observation group.Statistical significance could be seen,when comparisons were made between the 2 groups (P ＜0.01).Clinical efficacy of wound healing 2 weeks after surgery for the experimental group was obviously better than that of the control group,also with statistical significance (P ＜ 0.05).Conclusions HBO therapy after surgery could effectively control serum glucose level and promote incision healing in the patients with calcaneal fracture combined with diabetes mellitus.

Objective To investigate the clinical effects of hyperbaric oxygen on the control of serum glucose and healing of incision in the patients with calcaneal fracture complicated with diabetes mellitus following surgery.Methods Sixty cases of calcaneal fracture complicated with diabetes mellitus hospitalized from August 2015 to August 2016 were designated as the HBO group and the control group,in accordance with different wards designated,and each group consisted of 30 cases.The patients in the control group were given conventional postsurgical treatment and nursing,such as elevation of the affected limb,control of blood glucose,repercussion and promotion of bone healing,while the patients in the HBO group received HBO therapy,in addition to conventional therapy and nursing.Serum glucose level and healing of incision 2 weeks after surgery were closely observed and compared between the patients of the 2 groups.Results There was no statistical significance in the level of fasting blood glucose and glycosylated hemoglobin for the patients of the HBO group on the first day after surgery,as compared with those of the control group (P ＞ 0.05).Fasting blood glucose levels of the HBO group on the third,seventh and tenth days after surgery were respectively (5.5 ± 1.1) mmol/L,(5.4 ± 1.2) mmol/L and (5.2 ± 1.2) mmol/L,while those of the control group were (7.6 ± 0.7) mmol/L,(7.4 ± 0.9) mmol/L and (7.5 ± 0.9) mmol/L respectively.Blood glucose levels 2 hours after meal for the HBO group were respectively (8.4 ± 1.1) mmol/L,(7.9 ± 1.2) mmol/L and (8.2 ± 1.2) mmol/L,while those for the control group were (10.5 ± 1.1) mmol/L,(10.4 ± 1.2) mmol/L and (10.9 ± 1.2) mmol/L respectively.Glycosylated hemoglobin level for the patients of the HBO group on the seventh day after surgery was(6.7 ±0.4)％,while that of the control group was (7.3 ±0.6)％,which was obviously higher than that of the observation group.Statistical significance could be seen,when comparisons were made between the 2 groups (P ＜0.01).Clinical efficacy of wound healing 2 weeks after surgery for the experimental group was obviously better than that of the control group,also with statistical significance (P ＜ 0.05).Conclusions HBO therapy after surgery could effectively control serum glucose level and promote incision healing in the patients with calcaneal fracture combined with diabetes mellitus.