Dendritic cells (DCs) serve as the primary antigen-presenting cells in autoimmune diseases, like rheumatoid arthritis (RA), and exhibit distinct signaling profiles due to antigenic diversity. Type II collagen (CII) has been recognized as an RA-specific antigen; however, little is known about CII-stimulated DCs, limiting the development of RA-specific therapeutic interventions. In this study, we show that CII-stimulated DCs display a preferential gene expression profile associated with migration, offering a new perspective for targeting DC migration in RA treatment. Then, saikosaponin D (SSD) was identified as a compound capable of blocking CII-induced DC migration and effectively ameliorating arthritis. Optineurin (OPTN) is further revealed as a potential SSD target, with Optn deletion impairing CII-pulsed DC migration without affecting maturation. Function analyses uncover that OPTN prevents the proteasomal transport and ubiquitin-dependent degradation of C-C chemokine receptor 7 (CCR7), a pivotal chemokine receptor in DC migration. Optn-deficient DCs exhibit reduced CCR7 expression, leading to slower migration in CII-surrounded environment, thus alleviating arthritis progression. Our findings underscore the significance of antigen-specific DC activation in RA and suggest OPTN is a crucial regulator of CII-specific DC migration. OPTN emerges as a promising drug target for RA, potentially offering significant value for the therapeutic management of RA.

Ribosomopathies encompass a spectrum of disorders arising from impaired ribosome biogenesis and reduced functionality.Mutation or dysexpression of the genes that disturb any finely regulated steps of ribosome biogenesis can result in different types of ribosomopathies in clinic,collectively known as ribosomopathy genes.Emerging data suggest that ribosomopathy patients exhibit a significantly heightened susceptibility to cancer.Abnormal ribosome biogenesis and dysregulation of some ribo-somopathy genes have also been found to be intimately associated with cancer development.The cor-relation between ribosome biogenesis or ribosomopathy and the development of malignancies has been well established.This work aims to review the recent advances in the research of ribosomopathy genes among human cancers and meanwhile,to excavate the potential role of these genes,which have not or rarely been reported in cancer,in the disease development across cancers.We plan to establish a theoretical framework between the ribosomopathy gene and cancer development,to further facilitate the potential of these genes as diagnostic biomarker as well as pharmaceutical targets for cancer treatment.

Objective:To explore the application effect of health education based on knowledge, attitude and practice model in improving readiness for hospital discharge and quality of discharge guidance for patients undergoing intracranial aneurysm surgery.Methods:Using the convenient sampling method, a total of 152 patients who underwent craniotomy and intravascular interventional embolization in Neurosurgery Department of the First Affiliated Hospital of Xinjiang Medical University from July 2019 to May 2020 were selected. According to the random number table method, they were divided into in the control group and the experimental group, with 76 cases in each group. The experimental group was given health education based on knowledge, attitude and practice model at basis of routine discharge guidance health education, while the control group was given routine discharge guidance health education. The scores of readiness for hospital discharge and quality of discharge guidance of the two groups were compared.Results:The total score of readiness for hospital discharge in experimental group was (90.80±7.63) , which was higher than that in control group (55.34±9.80) . The total score of quality of discharge guidance of the experimental group was (159.11±10.79) , which was higher than (80.45±12.65) of the control group, and the differences were statistically significant ( t= -24.893, -41.230; P<0.01) . Conclusions:The implementation of health education based on knowledge, attitude and practice model can effectively improve readiness for hospital discharge and quality of discharge guidance for patients undergoing intracranial aneurysm surgery.

Objective To observe the characteristics of brain activation of multiple sclerosis (MS) patients and healthy controls at functional magnetic resonance imaging (fMRI) with olfactory stimulation,determine the locations of activation in areas of olfactory center and explore the MS olfactory related network.Methods Eighteen MS patients from the Affiliated Hospital of North Sichuan Medical College from February 2017 to March 2018 were enrolled as MS group,and 20 matched healthy adults during the same period served as controls.The Visual Analogue Scale was used to evaluate olfactory function in all subjects,the rest structure MRI was performed first,and volatile gases of lavender and rose solution were used to alternately stimulate olfactory during fMRI scanning.The brain activation was obtained by using matlab2013a and SPM8 softwares.The distribution and quantity of demyelination lesions were counted on T2 weighted image,and Spearman correlation analysis was done with SPSS 17.0 software package.Results The activated brain areas in the healthy control group included bilateral middle frontal gyrus,bilateral insula,bilateral supramarginal gyrus,bilateral orbitofrontal gyrus,right thalamus,right central anterior gyrus,bilateral cingulated gyrus,bilateral hippocampus,bilateral amygdala and bilateral superior frontal gyrus (t =2.11,P＜0.05).The activated brain areas in the MS group included right cerebellum,left insula,left superior temporal gyrus,right inferior frontal gyrus (t=2.19,P＜0.05).Compared with the control group,the MS group showed statistically significant decrease in activated values in right insula,right amygdala,right inferior frontal gyrus,right frontal middle gyrus,and the left supramarginal gyrus (t=2.04,P＜0.05).The distribution and number of demyelination lesions and major activation of brain regions with olfactory in the MS group demonstrated no significant correlation (r=-0.524,P=0.054).Conclusions Multiple brain areas involved in the olfactory processing and olfactory-related brain network existed.The activation of olfactory center had dominance in the right brain.The activation of the brain area in the MS group was significantly reduced,and the activation voxel and activation intensity were weakened.The olfactory-related brain network changed in MS patients.The distribution and number of demyelination lesions had no significant effect on the major activation of brain regions with olfactory stimulation.

Parkinson's disease (PD) is one of the most common forms of neurodegenerative diseases and increases in incidence with aging.Low mortality and high disability rates bring huge economic and psychological burden to society and families.PD manifested as motor symptoms and non-motor symptoms.Recent studies have shown that non-motor symptoms,such as sensory disorder,are the significant symptoms in early stages of PD and influence quality of life of PD patients.This review focuses on the characteristics and electrophysiological changes of sensory disorders (olfactory,visual,auditory,vestibule function,pain,etc) in PD patients to provide help for the early diagnosis,disease monitoring and efficacy evaluation of PD.

Objective To explore a model of day care fitting the local and regional characteristics to serve all the ethnic groups in Xinjiang, and analyze its performance. Methods Such indicators as the outpatient visits, discharges, average days of stay, and preoperative bed-occupying days of the hospital from 2010 to 2015 before the day-care mode was in place, were selected and compared against those since the mode in place from 2016 to 2018.Also compared were six typical diseases common for day surgery in day surgery wards sent from various departments, with non-day-surgery patients of the same period before.The comparison covered such indicators as nursing cost, laboratory examination cost, treatment cost, drug cost, consumables cost, drug cost ratio and average hospitalization cost between the two modes. The data were subject to statistical analysis using t test and χ2 test.Results Since day care mode in place, the average days of stay(8.93 days vs.7.72 days)and preoperative bed-occupying days(3.50 days vs.3.01 days) both decreased significantly, given the gradual growth of outpatients and discharges. Average hospitalization expenses of the six groups dropped significantly as well( P<0.05).Conclusions Day care mode can not only enhance the utilization of hospital beds to add to the income structure positively, but also significantly reduce the patients′hospitalization expenses, thus improving patient experience and satisfaction.

Objective The "heuristic" teaching rounds were applied to cardiovascular diseases and we observed the application effect . Methods From January to March 2017, 56 resident physicians at internal medicine base in the First Affiliated Hospital of Xinjiang Medical University were randomly divided into the experimental group and the control group, with 28 people of each group. The experimental group mainly adopted heuristic teaching rounds, and the control group adopted conventional teaching rounds. Interview method was used to interview the instructors , resident physicians , doctors and nurses in preparation for teaching rounds, the implementation process, the expected goals and effects. 56 resident physicians evaluated the preparation, guidance process, guidance methods and outcomes of ward rounds. SPSS 19.0 was used for statistical analysis, and rank sum test was used for evaluation results. Results As to the familiarity of the instructor on the condition (82.15％vs. 30.86％), guiding the training of humanistic care (92.86％ vs. 39.29％), physical examination (96.43％ vs. 28.57％), analysis of auxiliary examination (85.71％vs. 35.71％), writing medical records (85.72％ vs. 14.29％), summarizing the characteristics of cases (78.57％vs. 35.71％), diagnosis and differential diagnosis (85.71％vs. 21.43％), treatment plan making (85.71％vs. 25.00％), question formulation (89.29％vs. 30.72％), explanation of difficult problems and new progress ( 78 . 57％ vs . 17 . 86％) , content summary ( 92 . 85％ vs . 28 . 58％) the experimental group was significantly higher than the control group. In the experimental group, the teaching rounds of communication (96.43％vs. 46.43％), history acquisition techniques (85.72％vs. 21.43％), examination techniques (92.86％vs. 28.57％), clinical thinking (92.86％ vs. 28.57％), learning interests (96.43％ vs. 25.00％) and efficiency (85.71％ vs. 14.28％), the understanding and memory of knowledge (85.72％ vs. 28.57％), the problem solving ability (89.29％ vs. 21.43％), improvement of team collaboration (67.86％ vs. 28.57％) were significantly higher than those in the control group (P<0.05). Conclusion The "heuristic" teaching rounds attached great importance to preparation before and after class, focusing on resident physicians' active participation and teamwork, integrating humanistic care and communication skills, giving full play to the resident physicians motivation so as to ensure their efficient learning.

Objective To evaluate the effects of low blood sugar production index (LGI) combined with low blood sugar production burden (LGL) dietary intervention on blood glucose, oxidative stress and anthropometric indicators in type 2 diabetes mellitus. Methods A total of 150 cases of type 2 diabetes were randomly divided into two groups,maintain the original treatment plan of two groups,75 patients in the control group were given traditional food interchange method for dietary intervention;the experimental group of 75 patients, provide food education based on LGI+LGI food exchange method , the time period of 3 months. Fasting blood glucose (FPG)、2h postprandial blood glucose (2hPG), Glycated hemoglobin (HbAlc), Superoxide dismutase (SOD), Malondialdehyde (MDA), Vitamin C, Vitamin E, Body Mass Index (BMI), Waist circumference (WC) Upper arm muscle circumference (AMC), Triceps skin fold thickness (TSF) were observed before and after the intervention. Results There were no significant differences in blood glucose, oxidative stress and anthropometry between the two groups (P>0.05). After intervention, in the control group: FPG, 2hPG, HbAlc, SOD, MDA, Vitamin C, Vitamin E, BMI, WC, AMC, TSF were (10.27 ± 2.67) mmol/L, (11.51 ± 2.54) mmol/L, (8.78 ± 1.95)%, (322.73 ± 51.97) kU/L, (5.80 ± 1.76)μmol/L, (40.78±4.86)μmol/L, (19.33±4.79)μmol/L, (23.94±3.18) kg/m2, (89.57±10.23) cm, (24.10± 3.01) cm, (18.38 ± 3.79)mm respectively. In the experimental group: they were (8.76 ± 2.77) mmol/L, (10.63 ± 1.76) mmol/L, (7.96 ± 1.86)%, (357.29 ± 60.04) kU/L, (5.26 ± 1.33)μmol/L, (44.01 ± 7.06)μmol/L, (21.58 ± 5.25) μmol/L, (22.93 ± 2.75) kg/m2, (86.05 ± 10.79) cm, (22.75 ± 2.86) cm, (16.98 ± 4.48) mm respectively. There was significant difference between the two groups after intervention (t=2.049-3.769, all P < 0.05). In the experimental group, the improvement of blood sugar, oxidative stress and anthropometry was better than that of the control group (P < 0.05). Conclusions LGI combined with LGL diet intervention is better than the traditional method of food interchange, the blood glucose, oxidative stress and anthropometric indicators have improved, which can improve treatment efficacy in type 2 diabetes and easy for home self-management.

Objective To explore the effects of CICARE communication model combined with WeChat health education on self-management capacity, focal absorption and indexes of glucose metabolism among patients with type 2 diabetes mellitus (T2DM) combined with pulmonary tuberculosis (PTB). Methods A total of 80 patients with T2DM combined with PTB at Chest Hospital of Xinjiang Uyghur Autonomous Region were selected by convenience sampling from 1st January 2016 to 31st December 2016. They were divided into control group (n=40) and observation group(n=40) with the method of the random number table. Patients in control group received conventional nursing and health education during hospitalization and at discharge. On the basis of control group, patients in observation group received nursing with the CICARE communication model along with health education by WeChat after discharge. The self-management capacity, focal absorption and effective rate, index of glucose metabolism of patients of both groups were compared six months after intervention.Results Before intervention, there were no statistically significant differences in self-management capacity and index of glucose metabolism (P> 0.05). Six months after intervention, the score of self-management capacity and effective rate of treatment in observation group was higher than those in control group. Besides, the fasting plasma glucose (FPG), 2-hour postprandial blood glucose (2hPG) and glycosylated hemoglobin in observation group were lower than those in control group with significant differences (P< 0.05). Conclusions The CICARE communication model combined with the communication and propagation function of WeChat can improve the self-management and clinical symptoms. Moreover, it has a synergistic action in improving treatment effects.

Objective To explore the effect of clinical practice on clinical practice ability in master of nursing specialist and evaluation measures of the clinical practice ability.Methods A total of 17 masters of nursing specialist engaged in clinical practice were selected in the First Affiliated Hospital of Xinjiang Medical University from March 2014 to February 2016.They were cultivated with two-level management methods of instruction between tutors and clinical teachers along with following up the requirements of “Nursing Postgraduates Clinical Practice Handbook”.The clinical practice ability evaluation form of master of nursing specialist was used to evaluate the clinical practice ability of 17 postgraduates from 4 aspects including graduate teachers,clinical teachers,classmates,self evaluation from 360°feedback.Results After clinical practice, the score of 4 aspects and the total score of clinical practice ability were higher than those before clinical practice with significant differences (P <0.05 ).However,the results of 360°feedback showed that there were no statistically significant differences in the score of theoretical level,professional ethics,ability to research and the total score among different evaluation subjects (P >0.05 ).Besides,the results revealed that there were statistically significant differences in the evaluation of practice ability of nursing and teaching management ability (P <0.05).In addition,the score of practice ability of nursing care and management capacity of teaching evaluated by classmates were higher than those evaluated by other subjects (P <0.05).Conclusions Scientific clinical practice teaching mode of master of nursing specialist can effectively improve clinical practice ability of postgraduates.Besides,the 360°feedback can be seen as an effective tool to objectively and fairly evaluate clinical practice ability of high-quality and utility-type nursing talents.