Objective To compare the clinical efficacy and safety of ultrasound-guided microwave ablation(MWA)combined with percutaneous ethanol injection(PEI)and MWA alone for the treatment of cystic-solid thyroid nodules.Methods A computerized retrieval of academic papers concerning the randomized controlled trials(RCT)on the comparison of the effectiveness and safety between MWA combined with PEI(combination group)and MWA alone(simple MWA group)for cystic-solid thyroid nodules from the databases of PubMed,China National Knowledge Internet(CNKI),Wanfang Database,etc.was conducted.The quality of the enrolled articles was assessed according to the Newcastle-Ottawa scale(NOS)score.Results A total of six articles including 458 patients were finally included in this meta-analysis.Meta-analysis showed that the volume reduction rate of cystic-solid thyroid nodules in the combination group was higher than that of the simple MWA group(P＜0.05).No statistically significant differences in the complication incidences of hoarseness and fever existed between the two groups(both P＞0.05),but the complication incidences of bleeding and neck pain in the combination group were lower than those in the simple MWA group(both P＜0.05).Conclusion In treating cystic-solid thyroid nodules,MWA combined with PEI is superior to MWA alone in the curative effect and clinical safety.

Objective To explore the predictive value of contrast-enhanced echocardiography com-bined with serum levels of CD137 and insulin-like growth factor binding protein 6(IGFBP-6)for cardiovascular adverse events(MACE)in elderly patients with stable coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods A total of 108 elderly patients with stable CHD(CHD group)who visited Department of Cardiology of Changsha First Hospital from March 2020 to March 2022 were recruited in this study.They were grouped into a non-MACE group(81 cases)and a MACE group(27 cases)according to whether MACE occurred after PCI.Another 100 healthy individuals who taking physical examination during the same period served as control group.Their serum CD137 and IGFBP-6 levels were detected,and the contrast agent filling speed(β value)and maximum number of microbubbles(A value)were calculated based on the results of contrast-enhanced echocardiography.Their general clinical data were col-lected.ROC curve analysis and multivariate logistic regression analysis were used to analyze the data.Results The serum levels of CD137 and IGFBP-6 were significantly higher,while the β value and A value were obviously lower in the CHD group than the control group(P＜0.01).And the serum levels were notably higher,and the β value and A value were remarkably lower in the MACE group than the non-MACE group(P＜0.01).The AUC of cardiac ultrasound parameters βvalue and A value combined with serum CD137 and IGFBP-6 to predict MACE after PCI in CHD patients was 0.930,which was significantly higher than the AUC value of every single indicator(P＜0.01).β value,A value,CD137 and IGFBP-6 levels were all risk factors for the occurrence of MACE in CHD patients after PCI(P＜0.01).Conclusion Contrast-enhanced echocardiography,serum CD137 and IGFBP-6 levels have certain predictive value for MACE in elderly CHD patients after PCI,and combined detection has higher predictive value.

OBJECTIVE To investigate the expression of serum miR-222-3p in papillary thyroid carcinoma and its clinical significance.METHODS Total RNA in serum was extracted from 121 patients of papillary thyroid carcinoma and benign thyroid diseases.The reverse transcription quantitative real-time polymerase chain reaction(qRT-PCR) method was used to detect the expression of miR-222-3p,and then the potential correlation between serum miR-222-3p and clinical pathological characteristics of papillary thyroid carcinoma was analyzed.The receiver operating characteristic area under the curve(ROCAUC) and their index for diagnosis evaluation were also calculated.RESULTS The median expression level of serum miR-222-3p in papillary thyroid carcinoma patients was significantly higher than that of control group (2.2188 vs 0.7022,P=0.002).Although the expressions of serum miR-222-3p was not associated with the gender,age,capsule invasion,TNM stage,but it was positively correlated with tumor size,bilateral involvement,lesion quantity and lymph node status.ROC curve analysis showed that the specificity and sensitivity of the miR-222-3p diagnosis of papillary thyroid cancer were 79.75％ and 61.90％,respectively,while the ROC-AUC was 0.717.CONCLUSION The serum miR-222-3p is over expressed in papillary thyroid carcinoma and its expression is significantly correlated with tumor progression.It will be helpful for PTC diagnosis.

Long non-coding RNA(lncRNA) is non-protein coding transcripts longer than 200 nucleotides,which plays an important role in the development of the metabolic process.Thyroid cancer is the most common cancer of the endocrine system,and as reported,lncRNA is related to the occurrence and development of thyroid tumors.Therefore,this paper reports the latest domestic and foreign research progress about lncRNA in thyroid tumor,in order to provide new ideas for molecular diagnosis and treatment of thyroid cancer.

Objective To analyze on the responsibility of government for drug price addition canceling policy on incomes . Methods We Collected the 3-A hospital financial information statements and drug use data from January 2013 to September 2013 ( before reform) and from October 2013 to June 2014 ( after reform) .Results After taking evaluation of drug price addition cance-ling policy on incomes in the hospital, outpatient visits grew 9.62%, discharges increases 3.50%, and the outpatient average com-pensation fell by 4.69% and hospitalization fees per person increase 3.58%.Conclusion Preliminary results were obtained in con-trolling health care costs, medical services in ascension.The government's economic compensation economic compensation is difficult to make up for the cancellation of drug addition and reduce the reasonable income .It is suggested that we should improve the compen-sation scheme and assessment standards, and further strengthen the hospital internal management.