Tumor has become a major social problem threatening human life and health,and the multimodal integrated treat-ment method has greatly improved the prognosis and life quality of cancer patients.Studies have shown that cancer patients are prone to emotional disorders such as depression and anxiety,and tumor-related depression has directly affected the efficacy and prognosis of patients.This article focuses on the epidemiology,mechanism,and clinical diagnosis and treatment characteristics of tumor related de-pression,and reviews domestic and foreign research in order to provide references for the diagnosis and treatment of tumor related de-pression and improve the treatment effect of tumor patients.