ObjectiveThis paper aims to observe the syndrome improvement and negative antigen conversion rate of Qingxuan Daozhi formula in the treatment of influenza in children （heat accumulation in the lung and stomach syndrome）. MethodsThrough a multi-center randomized controlled methodology design，confirmed influenza cases were collected from October 2022 to April 2023 in the pediatrics department of eight hospitals，such as Dongfang Hospital of Beijing University of Chinese Medicine. A total of 180 children with influenza and heat accumulation in the lung and stomach syndrome conforming to the standard were recruited through the clinic. The sick children meeting the inclusion criteria were randomly divided into groups by a block-randomized method. The children in the experimental group were treated with Qingxuan Daozhi formula for five days，and those in the control group were treated with Oseltamivir Phosphate Granules for five days. The primary efficacy indicator was the negative conversion rate of influenza antigen detection. Secondary efficacy indicators were the Canadian acute respiratory illness and flu scale （CARIFS） and the incidence of complications，severe cases， and critical cases. Follow-up observation was conducted on the day of enrollment，48 hours after medication，72 hours after medication， and （6+1） d after medication. ResultsOne hundred and eighty participants were randomly assigned to the experimental group （90 cases） or the control group （90 cases）. All participants were followed up during the study. Comparison of influenza antigen detection results in the primary efficacy indicators showed that the average time of negative influenza antigen conversion in the experimental group was （5.29±1.25） d，and that in the control group was （5.40±1.68） d，without a statistically significant difference. After five days of intervention，52 cases in the experimental group and 51 cases in the control group converted to negative，without a statistically significant difference. CARIFS score results in the secondary efficacy indicators showed that during 72 hours after intervention，there were statistically significant differences between the experimental group and the control group in three dimensions， including headache，muscle soreness， and the need for extra care （P<0.05）. On the （6+1） days after the intervention，the differences in both the experimental group and the control group were statistically significant in 10 dimensions， including sore throat，bad sleep，uncomfortable feeling，poor spirit and fatigue，crying more than usual，the need for extra care，symptom，function，influence on parents，and total score （P<0.05）. The comparison results within the group in the dimensional scores of symptom， function， and influence on parents，as well as the CARIFS total score showed that with the delay of follow-up time，scores of both groups decreased significantly，with a statistically significant difference （P<0.01）. Inter-group comparison results showed that the mean score of the experimental group was higher than that of the control group at the time of enrollment. With the progress of intervention，the score of the experimental group was significantly decreased compared with that of the control group. At the end of follow-up，the mean score of the experimental group was lower than that of the control group，with no statistically significant difference. In terms of the incidence of complications，severe cases， and critical cases， there were no complications，severe cases， and critical cases in the two groups，without a statistically significant difference. ConclusionThe symptom improvement effect and negative antigen conversion rate of Qingxuan Daozhi formula in the treatment of influenza in children （heat accumulation in the lung and stomach syndrome） are not inferior to Oseltamivir Phosphate granules， and children's acceptance is better. It can be more widely used in clinical treatment of influenza in children （heat accumulation in the lung and stomach syndrome）.

Objective:To systematically analyze the incidence and influencing factors of frailty in elderly patients with hematologic malignancies.Methods:Research on frailty in elderly patients with hematologic malignancies was retrieved from Chinese and English databases such as China National Knowledge Infrastructure, Wanfang Data, PubMed, and Web of Science. The search period was from database establishment to August 23, 2024. Two researchers screened the included studies, conducted quality assessment, and extracted data. Meta-analysis was conducted using Stata 18 and RevMan 5.4.Results:A total of seven studies were included, encompassing 19 076 elderly hematologic malignancy patients, with a frailty incidence of 59% [95% CI (0.48, 0.69) ]. Meta-analysis revealed that age [ MD=4.31, 95% CI (3.67, 4.96) ], gender [ OR=0.88, 95% CI (0.83, 0.93) ], alcohol consumption [ OR=1.67, 95% CI (1.15, 2.44) ], self-care ability [ MD=-1.79, 95% CI (-3.17, -0.41) ], anemia [ OR=6.67, 95% CI (2.94, 15.14) ], infection [ OR=1.81, 95% CI (1.16, 2.84) ], and neuropathy [ OR=2.52, 95% CI (1.38, 4.61) ] were the influencing factors of frailty in elderly patients with hematologic malignancies. Conclusions:The incidence of frailty is high in elderly patients with hematologic malignancies. Elderly patients with hematologic malignancies who are older, female, consume alcohol, have low self-care ability, anemia, infections, and neuropathy are prone to frailty. Healthcare providers can conduct early screening and intervention for high-risk populations of frailty based on risk factors to improve the quality of life for elderly hematologic malignancy patients.

Objective:To study the application of Internet+ follow-up model based on nutrition support team (NST) cooperation in enteral nutrition therapy for patients with inflammatory bowel disease (IBD).Methods:From November 2021 to April 2023, 98 IBD patients admitted to the First Affiliated Hospital of Anhui Medical University were prospectively enrolled and were divided into the observation and control groups (49 cases in each group) using a random number table. The observation group received the intervention of Internet+ follow-up based on NST cooperation and the control group was given routine telephone follow-up. The nutritional indicators, IBD quality of life score, and patient satisfaction with care were compared between the two groups before and 3 months after the intervention.Results:After intervention, the serum albumin, hemoglobin, and pre-albumin levels in the observation group were significantly higher than those in the control group (all P<0.05). After intervention, the IBD quality of life scores of patients in the observation group were significantly higher than those in the control group, in the domains including daily activities, bowel function, social function, and emotional ability (all P<0.05). The patient satisfaction with care in the observation group was 93.62% (44/47), which was significantly higher than that (76.60%, 36/47) in the control group ( P<0.05). Conclusion:The Internet+ follow-up model based on NST cooperation favors the enteral nutrition therapy for patients with IBD as it improves the nutritional status, quality of life, and patient satisfaction with care.

Objective:To systematically analyze the incidence and influencing factors of frailty in elderly patients with hematologic malignancies.Methods:Research on frailty in elderly patients with hematologic malignancies was retrieved from Chinese and English databases such as China National Knowledge Infrastructure, Wanfang Data, PubMed, and Web of Science. The search period was from database establishment to August 23, 2024. Two researchers screened the included studies, conducted quality assessment, and extracted data. Meta-analysis was conducted using Stata 18 and RevMan 5.4.Results:A total of seven studies were included, encompassing 19 076 elderly hematologic malignancy patients, with a frailty incidence of 59% [95% CI (0.48, 0.69) ]. Meta-analysis revealed that age [ MD=4.31, 95% CI (3.67, 4.96) ], gender [ OR=0.88, 95% CI (0.83, 0.93) ], alcohol consumption [ OR=1.67, 95% CI (1.15, 2.44) ], self-care ability [ MD=-1.79, 95% CI (-3.17, -0.41) ], anemia [ OR=6.67, 95% CI (2.94, 15.14) ], infection [ OR=1.81, 95% CI (1.16, 2.84) ], and neuropathy [ OR=2.52, 95% CI (1.38, 4.61) ] were the influencing factors of frailty in elderly patients with hematologic malignancies. Conclusions:The incidence of frailty is high in elderly patients with hematologic malignancies. Elderly patients with hematologic malignancies who are older, female, consume alcohol, have low self-care ability, anemia, infections, and neuropathy are prone to frailty. Healthcare providers can conduct early screening and intervention for high-risk populations of frailty based on risk factors to improve the quality of life for elderly hematologic malignancy patients.

Objective:To study the application of Internet+ follow-up model based on nutrition support team (NST) cooperation in enteral nutrition therapy for patients with inflammatory bowel disease (IBD).Methods:From November 2021 to April 2023, 98 IBD patients admitted to the First Affiliated Hospital of Anhui Medical University were prospectively enrolled and were divided into the observation and control groups (49 cases in each group) using a random number table. The observation group received the intervention of Internet+ follow-up based on NST cooperation and the control group was given routine telephone follow-up. The nutritional indicators, IBD quality of life score, and patient satisfaction with care were compared between the two groups before and 3 months after the intervention.Results:After intervention, the serum albumin, hemoglobin, and pre-albumin levels in the observation group were significantly higher than those in the control group (all P<0.05). After intervention, the IBD quality of life scores of patients in the observation group were significantly higher than those in the control group, in the domains including daily activities, bowel function, social function, and emotional ability (all P<0.05). The patient satisfaction with care in the observation group was 93.62% (44/47), which was significantly higher than that (76.60%, 36/47) in the control group ( P<0.05). Conclusion:The Internet+ follow-up model based on NST cooperation favors the enteral nutrition therapy for patients with IBD as it improves the nutritional status, quality of life, and patient satisfaction with care.

Objective To explore the effects of oleanolic acid on NF-κB/caspase-9 signaling pathway in kidneys of rat with diabetic nephropathy.Methods The diabetic nephropathy model rats were established,and the model rats were randomly divided intooleanolic acid low,medium and high dose groups,metformin group,and model group,with another 12 healthy SD rats as control group.The levels of blood glucose were measured at weeks 1,2 and 3 post-drug administration,and blood lipid and 24h urine urinary microalbumin(UMA)were measured after entire drug administration.Furthermore,we also detected the renal histopathology of rats,apoptosis of renal tubular,glomerular cells,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and protein expression of NF-κB/caspase-9 signaling pathway.Results Compared with the control group,the model group demonstrated higher levels of blood glucose at weeks 1,2 and 3,blood lipid,UMA,TNF-α and IL-6,higher proportion of apoptotic renal tubular and glomerular,and higher expressions of caspase-9 protein and p-NF-κB p65/NF-κB p65(P＜0.05).Compared with the model group,the pathological damage of renal tissue in the metformin group and oleanolic acid low,middle and high dose groups were alleviated,the levels of blood glucose at weeks 1,2 and 3,blood lipid,UMA,TNF-α and IL-6,the proportion of apoptotic renal tubular and glomerular,and the expressions of caspase-9 proteins and p-NF-κB p65/NF-κB p65 were decreased,and these indexes in oleanolic acid groups showed a dose-dependent manner(P＜0.05).Conclusion Oleanolic acid can improve the metabolism of glucose and lipid,reduce the pathological damage of renal tissue,inhibit the apoptosis of renal tubular and glomerular,and inhibit the NF-κB/caspase-9 pathway in diabetic nephropathy rats.

Objective:This study aims to explore the intervention effects of five different intelligent rehabilitation technologies, namely immersive virtual reality (imVR), non-fully immersive virtual reality (Nf-imVR), augmented reality, brain-computer interface (BCI), and rehabilitation robot (RT), on the upper limb function and activities of daily living of stroke patients with upper limb dysfunction.Methods:A computer-based search was conducted in PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Databases for randomized controlled trials (RCT) on the intervention effects of different intelligent rehabilitation technologies on stroke patients with upper limb dysfunction. Manual search and other retrieval methods were also supplemented. The retrieval time limit was from the establishment of the databases to May 31, 2024. Data were extracted and the methodological quality was evaluated, and a network Meta-analysis was performed using Stata 17.0 software.Results:A total of 34 articals were included, involving 1 926 patients, and the studies included five intelligent rehabilitation technologies. The control groups all received dose-matched conventional physical training. The results of the network Meta-analysis showed that, compared with the dose-matched conventional physical training, in terms of improving upper limb function, the BCI had the best effect, followed by imVR, RT, Nf-imVR, and augmented reality in sequence; in terms of improving activities of daily living, the BCI still had the best effect, followed by imVR, RT, augmented reality, and Nf-imVR in sequence. The clustering ranking of upper limb function and activities of daily living was BCI >imVR > RT > Nf-imVR > augmented reality in turn.Conclusions:Intelligent rehabilitation technologies have advantages in improving the upper limb function and activities of daily living of stroke patients with upper limb dysfunction, and the BCI has obvious advantages.

Objective:This study aims to explore the intervention effects of five different intelligent rehabilitation technologies, namely immersive virtual reality (imVR), non-fully immersive virtual reality (Nf-imVR), augmented reality, brain-computer interface (BCI), and rehabilitation robot (RT), on the upper limb function and activities of daily living of stroke patients with upper limb dysfunction.Methods:A computer-based search was conducted in PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure, and Wanfang Databases for randomized controlled trials (RCT) on the intervention effects of different intelligent rehabilitation technologies on stroke patients with upper limb dysfunction. Manual search and other retrieval methods were also supplemented. The retrieval time limit was from the establishment of the databases to May 31, 2024. Data were extracted and the methodological quality was evaluated, and a network Meta-analysis was performed using Stata 17.0 software.Results:A total of 34 articals were included, involving 1 926 patients, and the studies included five intelligent rehabilitation technologies. The control groups all received dose-matched conventional physical training. The results of the network Meta-analysis showed that, compared with the dose-matched conventional physical training, in terms of improving upper limb function, the BCI had the best effect, followed by imVR, RT, Nf-imVR, and augmented reality in sequence; in terms of improving activities of daily living, the BCI still had the best effect, followed by imVR, RT, augmented reality, and Nf-imVR in sequence. The clustering ranking of upper limb function and activities of daily living was BCI >imVR > RT > Nf-imVR > augmented reality in turn.Conclusions:Intelligent rehabilitation technologies have advantages in improving the upper limb function and activities of daily living of stroke patients with upper limb dysfunction, and the BCI has obvious advantages.

OBJECTIVE To monitor the common pathogens for viral diarrhea in children under 5 years old in Wuxi area,and to analyze their epidemiological characteristics and trends.METHODS Diarrhea specimens were collected from inpatient and outpatient children with diarrhea in sentinel hospitals in Wuxi from 2018 to 2023.The norovir-us,rotavirus,sapovirus,enteradenovirus and astrovirus were detected by Real-time fluorescence quantitative pol-ymerase chain reaction(PCR),and the monitoring results were statistically analyzed.RESULTS A total of 654 vi-rus-positive cases were detected from 1898 diarrhea specimens with an overall detection rate of 34.46%.Among them,norovirus and rotavirus had the highest detection rates 12.54%and 11.70%,respectively.The detection rate of viruses was the highest in children aged 12 to<24 months,reaching 59.03%.In inpatient children with di-arrhea,rotavirus had the highest detection rate at 14.03%,while in outpatient children with diarrhea,norovirus had the highest detection rate at 11.93%.There was a significant difference in the detection rate of rotavirus be-tween inpatient and outpatient children(P<0.05).CONCLUSION Viral diarrheal diseases exhibit a notably high detection rate among children aged 12 to<24 months in Wuxi,suggesting the need to further optimize prevention and control measures for this age group.

Objective To compare the positioning errors,required planning target volume(PTV)outer expansion boundary and three-dimensional displacement of two different positioning fixation devices CIVCO Uni-frame carbon fiber adjustable angle head frame and domestic integrated board in radiotherapy for the pa-tients with head tumor,and to investigate the application value of CIVCO headrest in the positioning of head tumor radiotherpay.Methods The clinical data of 82 patients with head tumors who underwent radiotherapy in this hospital from January to December 2023 were analyzed retrospectively.The patients were divided into the adjustable angle head frame group and integrated plate group,41 cases in each group.Both groups were fixed with U-shaped thermoplastic head film.Radiotherapy was performed by using ELEKTA infinity linear accelerator.The cone beam computed tomography(CBCT)image guidance was used,combined with bone reg-istration and manual calibration to obtain the patient positioning errors in three directions:X axis,Y axis and Z axis.The positioning error data of each CBCT was recorded;based on the PTV outward expansion boundary formula(2.5∑+0.7σ),the PTV outward expansion boundaries required by the two fixation devices in all di-rections for the treatment of head tumors were calculated;the 3-dimensional spatial displacement was calculat-ed based on the patient's single radiotherapy positioning error.Results The absolute positioning errors in the X,Y,and Z directions of the adjustable angle head frame group were 0.13(0.07,0.22),0.16(0.16,0.27),0.10(0.05,0.18)cm respectively,which in the integrated board group were 0.14(0.07,0.24),0.18(0.08,0.32),0.09(0.04,0.10)cm respectively.The absolute error of the Y direction in the adjustable angle head frame group was smaller than that of the integrated board group(P=0.006),and the difference in the relative error between the two groups was not statistically significant(P＞0.05).According to the PTV expansion formula,the calculated expansion boundaries of the X,Y,and Z directions in the adjustable head frame group were 0.24,0.30,0.22 cm,which in the integrated plate group were 0.21,0.36,0.21 cm,respectively.The three-dimensional space comprehensive positioning error value could be calculated by the formula calculation using the positioning error values in three directions.The mean values of the three-dimensional space positio-ning errors of the adjustable angle headstock group and domestic integrated plate group were 0.320 cm and 0.340 cm respectively,there was no statistically significant difference between the two groups.Conclusion The absolute error in Y direction and the median value of three-dimensional displacement of the CIVCO adjustable angle head rest are smaller than those of the domestic integrated plate,which is worthy of clinical promoted applica-tion if conditions permit.