Objective To evaluate the effectiveness of therapeutic dentures with flat tables in edentulous patients with neuromuscular dysfunction.Methods Thirteen edentulous patients with neuromuscular dysfunction participated in this study.Initially,conventional complete dentures were fabricated using the biofunctional prosthetic system(BPS)method and delivered to the patients.The satisfaction questionnaire and oral health-related quality of life(OHRQoL)were assessed on the day of delivery and again two weeks later.The pa-tients whose grades of over-all satisfactory fewer than 8 were participated in neuromuscular training with therapeutic dentures.Subse-quently,4 mm of the occlusal surfaces of the mandibular artificial posterior teeth were removed to create flat tables.Once the mandibu-lar position was stabilized,new mandibular denture was fabricated and the same assessments were conducted on the day of delivery.Results In edentulous patients with neuromuscular dysfunction,there were no significant improvements in satisfaction,or OHRQoL on the day of delivery or two weeks later.However,significant improvements in satisfaction and OHRQoL were observed after the defin-itive dentures delivered following neuromuscular training(P＜0.05).Conclusion Thetherapeutic dentures with flat tables can improve the neuromuscular function in edentulous patients with neuromuscular dysfunction,significantly increasing their satisfaction in the den-tures,while also enhancing their quality of life.

Objective To evaluate the effectiveness of therapeutic dentures with flat tables in edentulous patients with neuromuscular dysfunction.Methods Thirteen edentulous patients with neuromuscular dysfunction participated in this study.Initially,conventional complete dentures were fabricated using the biofunctional prosthetic system(BPS)method and delivered to the patients.The satisfaction questionnaire and oral health-related quality of life(OHRQoL)were assessed on the day of delivery and again two weeks later.The pa-tients whose grades of over-all satisfactory fewer than 8 were participated in neuromuscular training with therapeutic dentures.Subse-quently,4 mm of the occlusal surfaces of the mandibular artificial posterior teeth were removed to create flat tables.Once the mandibu-lar position was stabilized,new mandibular denture was fabricated and the same assessments were conducted on the day of delivery.Results In edentulous patients with neuromuscular dysfunction,there were no significant improvements in satisfaction,or OHRQoL on the day of delivery or two weeks later.However,significant improvements in satisfaction and OHRQoL were observed after the defin-itive dentures delivered following neuromuscular training(P＜0.05).Conclusion Thetherapeutic dentures with flat tables can improve the neuromuscular function in edentulous patients with neuromuscular dysfunction,significantly increasing their satisfaction in the den-tures,while also enhancing their quality of life.

OBJECTIVES: This work aimed to construct N6-methyladenosine (m⁶A) regulator-based prognostic signature and evaluate the prognostic value and the intervention on tumor immune microenvironment of this m⁶A risk signature. METHODS: Using transcriptome and clinical data of head and neck squamous cell carcinoma (HNSCC) from The Cancer Genome Atlas (TCGA), we profiled m⁶A regulators and constructed an m⁶A risk signature. The relationship between m⁶A modulation and immune function was studied by differential gene expression, cell type enrichment, and correlation analyses. RESULTS: Fifteen m⁶A regulators had aberrant expression in HNSCC. A three-gene m⁶A prognostic signature (i.e., YTHDC2, IGF2BP2, and HNRNPC) was constructed and identified as an independent prognostic indicator for HNSCC. The m⁶A regulator signature-based high-risk group revealed pro-tumoral immune microenvironment due to the dysregulation of immune-related gene expression, abnormal enrichment of multiple immunocytes, and production of immunoregulatory factors. CONCLUSIONS This comprehensive analysis of m⁶A regulators and tumor immune landscape in HNSCC revealed that the m⁶A signature of YTHDC2, IGF2BP2, and HNRNPC could serve as a promising biomarker for monitoring HNSCC development and may be a potential target for tumor therapy in the future.
Humans ; Squamous Cell Carcinoma of Head and Neck/genetics* ; Gene Expression Regulation, Neoplastic ; Prognosis ; Head and Neck Neoplasms/genetics* ; Tumor Microenvironment/genetics* ; RNA-Binding Proteins/genetics* ; Heterogeneous-Nuclear Ribonucleoprotein Group C/genetics* ; RNA Helicases