Postoperative cognitive dysfunction (POCD) is a kind of common surgical complications, which can seriously affect the prognosis of patients. In recent years, research on POCD mechanism has attracted wide attention. In view of the importance of experimental animal models in mechanism research, this paper reviews the different POCD animal models and their potential pathogenic mechanisms, in order to clarify the characteristics and application of different POCD models. This study provides a reference for selection of experimental animal models in studying POCD mechanism.

Postoperative cognitive dysfunction (POCD) is a kind of common surgical complications, which can seriously affect the prognosis of patients. In recent years, research on POCD mechanism has attracted wide attention. In view of the importance of experimental animal models in mechanism research, this paper reviews the different POCD animal models and their potential pathogenic mechanisms, in order to clarify the characteristics and application of different POCD models. This study provides a reference for selection of experimental animal models in studying POCD mechanism.