Spine fracture and dislocation are common traumatic spinal conditions that often require surgical intervention due to compromised spinal stability. Surgical approaches include anterior, posterior, and combined anterior-posterior spinal procedures. According to the specific surgical requirements, patients may be placed in the prone position or repositioned between prone and supine positions during surgery. Intraoperative repositioning has become an essential step in patient positioning. However, during repositioning, patients with spinal fracture and dislocation are at increased risk for complications such as hemodynamic instability, nerve injury, and pressure injuries to the skin and soft tissue. Notably, due to the instability of the spinal cord, even minor manipulations can further exacerbate the damage, potentially leading to severe outcomes like paraplegia. Although the current clinical guidelines provide instructive recommendations for standard position, there remains no specific protocols for intraoperative repositioning in patients with spine fracture and dislocation. With a concern for the lack of clinical studies on positioning techniques, risk prevention, and operational norms for special patients, no applicable guidelines or standards are available. A consensus was required to provide clinical reference, meet the requirements of surgical treatment, and minimize the safety risks of patients caused by improper placement of positions. Professional Committee of Operating Room Nursing of Shaanxi Nursing Association organized experts in nursing management and operating room nursing from major hospitals across China to formulate Expert consensus on intraoperative repositioning for patients with spinal fracture and dislocation ( version 2025). The consensus provides 11 recommendations covering pre-repositioning preparation, intraoperative maneuvers, and post-repositioning observation, aiming to provide references for clinical standardization of the intraoperative repositioning process and protection of patients′ safety.

Spine fracture and dislocation are common traumatic spinal conditions that often require surgical intervention due to compromised spinal stability. Surgical approaches include anterior, posterior, and combined anterior-posterior spinal procedures. According to the specific surgical requirements, patients may be placed in the prone position or repositioned between prone and supine positions during surgery. Intraoperative repositioning has become an essential step in patient positioning. However, during repositioning, patients with spinal fracture and dislocation are at increased risk for complications such as hemodynamic instability, nerve injury, and pressure injuries to the skin and soft tissue. Notably, due to the instability of the spinal cord, even minor manipulations can further exacerbate the damage, potentially leading to severe outcomes like paraplegia. Although the current clinical guidelines provide instructive recommendations for standard position, there remains no specific protocols for intraoperative repositioning in patients with spine fracture and dislocation. With a concern for the lack of clinical studies on positioning techniques, risk prevention, and operational norms for special patients, no applicable guidelines or standards are available. A consensus was required to provide clinical reference, meet the requirements of surgical treatment, and minimize the safety risks of patients caused by improper placement of positions. Professional Committee of Operating Room Nursing of Shaanxi Nursing Association organized experts in nursing management and operating room nursing from major hospitals across China to formulate Expert consensus on intraoperative repositioning for patients with spinal fracture and dislocation ( version 2025). The consensus provides 11 recommendations covering pre-repositioning preparation, intraoperative maneuvers, and post-repositioning observation, aiming to provide references for clinical standardization of the intraoperative repositioning process and protection of patients′ safety.

Currently,China needs to comprehensively understand the theoretical support,historical experience,and practical requirements of new productive forces to support the construction of Healthy China,accurately grasp its core concepts and profound implications,clarify the strategic direction of new productive forces to support Healthy China,scientifically plan and implement precise measures,in order to find the best practice path for new productive forces to drive high-quality development of a Healthy China.

OBJECTIVE To mine the adverse drug events （ADE） signals for gilteritinib， and provide a reference for safe drug use in clinic. METHODS ADE reports with gilteritinib as the primary suspected drug were extracted from the FDA Adverse Event Reporting System （FAERS） database from February 1st， 2018 to December 31st， 2023. Reporting odds ratio （ROR） and proportional reporting ratio （PRR） were applied to detect the risk signals from the data in the FAERS database. The classification and statistics of collected signal data were conducted by using the preferred term （PT） and systemic organ class （SOC） in ADE terminology set of the Medical Dictionary for Regulatory Activities （24.1 edition）. RESULTS Totally， 2 755 gilteritinib-related ADE reports were collected from the database， involving 676 ADE signals （95 positive signals）， 313 PTs and 25 SOCs. Among them， nine signals were not recorded in the package insert. The top 5 PTs consisted of abnormal liver function， decreased platelet count， febrile neutropenia， pneumonia and myelosuppression. The top 6 SOCs for positive signal counts were examinations， general disorders and administration site conditions， respiratory， thoracic and mediastinal disorders， infections and infestations， heart organ disorders， and nervous system disorders. ADEs not recorded in the drug package insert included pneumonia， myelosuppression， decreased blood cell count， sepsis， hemorrhage， infection （not specifically referred to）， septic shock， respiratory failure， and aspergillosis. CONCLUSIONS In addition to paying attention to common ADEs such as liver dysfunction and thrombocytopenia， it is necessary to monitor ADEs with strong signals that are not mentioned in the drug instructions when using gefitinib， such as pneumonia， bone marrow suppression， cytopenia， sepsis， bleeding， infection （not specifically referred to）， septic shock， respiratory failure， Aspergillus infection， elevated serum creatinine and interstitial lung disease.

Currently,China needs to comprehensively understand the theoretical support,historical experience,and practical requirements of new productive forces to support the construction of Healthy China,accurately grasp its core concepts and profound implications,clarify the strategic direction of new productive forces to support Healthy China,scientifically plan and implement precise measures,in order to find the best practice path for new productive forces to drive high-quality development of a Healthy China.

Currently,China needs to comprehensively understand the theoretical support,historical experience,and practical requirements of new productive forces to support the construction of Healthy China,accurately grasp its core concepts and profound implications,clarify the strategic direction of new productive forces to support Healthy China,scientifically plan and implement precise measures,in order to find the best practice path for new productive forces to drive high-quality development of a Healthy China.

Currently,China needs to comprehensively understand the theoretical support,historical experience,and practical requirements of new productive forces to support the construction of Healthy China,accurately grasp its core concepts and profound implications,clarify the strategic direction of new productive forces to support Healthy China,scientifically plan and implement precise measures,in order to find the best practice path for new productive forces to drive high-quality development of a Healthy China.

Currently,China needs to comprehensively understand the theoretical support,historical experience,and practical requirements of new productive forces to support the construction of Healthy China,accurately grasp its core concepts and profound implications,clarify the strategic direction of new productive forces to support Healthy China,scientifically plan and implement precise measures,in order to find the best practice path for new productive forces to drive high-quality development of a Healthy China.

Currently,China needs to comprehensively understand the theoretical support,historical experience,and practical requirements of new productive forces to support the construction of Healthy China,accurately grasp its core concepts and profound implications,clarify the strategic direction of new productive forces to support Healthy China,scientifically plan and implement precise measures,in order to find the best practice path for new productive forces to drive high-quality development of a Healthy China.

Currently,China needs to comprehensively understand the theoretical support,historical experience,and practical requirements of new productive forces to support the construction of Healthy China,accurately grasp its core concepts and profound implications,clarify the strategic direction of new productive forces to support Healthy China,scientifically plan and implement precise measures,in order to find the best practice path for new productive forces to drive high-quality development of a Healthy China.