Chronic myeloid leukemia (CML) typically progresses from a chronic phase to an accelerated phase, and eventually to a blast crisis, often involving the bone marrow and peripheral blood, if left untreated. Central nervous system (CNS) involvement is an uncommon manifestation of CML, particularly as an isolated CNS relapse. Here, we present a rare case of CML in lymphoid blast crisis with an isolated CNS relapse. A 46-year-old female with underlying CML in lymphoid blast crisis, previously treated with chemotherapy and tyrosine kinase inhibitors, presented with visual disturbances. Imaging and cerebrospinal fluid analysis confirmed leukemic infiltration of the CNS without evidence of a systemic disease. Isolated CNS involvement is an atypical complication of CML and presents significant therapeutic challenges owing to the blood-brain barrier, which limits the efficacy of systemic therapies. Subsequently, the patient was treated with intrathecal chemotherapy targeting the CNS. Despite aggressive treatment, CNS relapse remains a major concern due to the limited penetration of standard therapies into the CNS. This case underscores the importance of early recognition of CNS symptoms in CML patients, particularly in those with blast crisis, and highlights the need for tailored therapeutic strategies to manage this rare and challenging manifestation.

Purpose: This study aimed to compare the anxiety, depression, and quality of life (QOL) among caregivers of children with cerebral palsy and those caring for typically developing children. Methods: A cross-sectional, comparative study was conducted using convenience sampling to recruit 60 subjects. Anxiety, depression, and QOL were assessed with the Generalized Anxiety Disorder-7 Scale, the Patient Health Questionnaire-9, and the World Health Organization Quality of Life-BREF Scale, respectively. Results: The mean age of caregivers of children with cerebral palsy was 33.63±6.94 years, compared to 32±5.003 years for caregivers of typically developing children. Caregivers of children with cerebral palsy exhibited significantly higher levels of anxiety and depression, as well as poorer QOL, than those caring for typically developing children (P<0.05). Conclusion Caregivers of children with cerebral palsy experience higher levels of anxiety and depression and a poorer QOL compared to caregivers of typically developing children.

Chronic myeloid leukemia (CML) typically progresses from a chronic phase to an accelerated phase, and eventually to a blast crisis, often involving the bone marrow and peripheral blood, if left untreated. Central nervous system (CNS) involvement is an uncommon manifestation of CML, particularly as an isolated CNS relapse. Here, we present a rare case of CML in lymphoid blast crisis with an isolated CNS relapse. A 46-year-old female with underlying CML in lymphoid blast crisis, previously treated with chemotherapy and tyrosine kinase inhibitors, presented with visual disturbances. Imaging and cerebrospinal fluid analysis confirmed leukemic infiltration of the CNS without evidence of a systemic disease. Isolated CNS involvement is an atypical complication of CML and presents significant therapeutic challenges owing to the blood-brain barrier, which limits the efficacy of systemic therapies. Subsequently, the patient was treated with intrathecal chemotherapy targeting the CNS. Despite aggressive treatment, CNS relapse remains a major concern due to the limited penetration of standard therapies into the CNS. This case underscores the importance of early recognition of CNS symptoms in CML patients, particularly in those with blast crisis, and highlights the need for tailored therapeutic strategies to manage this rare and challenging manifestation.

Purpose: This study aimed to compare the anxiety, depression, and quality of life (QOL) among caregivers of children with cerebral palsy and those caring for typically developing children. Methods: A cross-sectional, comparative study was conducted using convenience sampling to recruit 60 subjects. Anxiety, depression, and QOL were assessed with the Generalized Anxiety Disorder-7 Scale, the Patient Health Questionnaire-9, and the World Health Organization Quality of Life-BREF Scale, respectively. Results: The mean age of caregivers of children with cerebral palsy was 33.63±6.94 years, compared to 32±5.003 years for caregivers of typically developing children. Caregivers of children with cerebral palsy exhibited significantly higher levels of anxiety and depression, as well as poorer QOL, than those caring for typically developing children (P<0.05). Conclusion Caregivers of children with cerebral palsy experience higher levels of anxiety and depression and a poorer QOL compared to caregivers of typically developing children.

Purpose: This study aimed to compare the anxiety, depression, and quality of life (QOL) among caregivers of children with cerebral palsy and those caring for typically developing children. Methods: A cross-sectional, comparative study was conducted using convenience sampling to recruit 60 subjects. Anxiety, depression, and QOL were assessed with the Generalized Anxiety Disorder-7 Scale, the Patient Health Questionnaire-9, and the World Health Organization Quality of Life-BREF Scale, respectively. Results: The mean age of caregivers of children with cerebral palsy was 33.63±6.94 years, compared to 32±5.003 years for caregivers of typically developing children. Caregivers of children with cerebral palsy exhibited significantly higher levels of anxiety and depression, as well as poorer QOL, than those caring for typically developing children (P<0.05). Conclusion Caregivers of children with cerebral palsy experience higher levels of anxiety and depression and a poorer QOL compared to caregivers of typically developing children.

Chronic myeloid leukemia (CML) typically progresses from a chronic phase to an accelerated phase, and eventually to a blast crisis, often involving the bone marrow and peripheral blood, if left untreated. Central nervous system (CNS) involvement is an uncommon manifestation of CML, particularly as an isolated CNS relapse. Here, we present a rare case of CML in lymphoid blast crisis with an isolated CNS relapse. A 46-year-old female with underlying CML in lymphoid blast crisis, previously treated with chemotherapy and tyrosine kinase inhibitors, presented with visual disturbances. Imaging and cerebrospinal fluid analysis confirmed leukemic infiltration of the CNS without evidence of a systemic disease. Isolated CNS involvement is an atypical complication of CML and presents significant therapeutic challenges owing to the blood-brain barrier, which limits the efficacy of systemic therapies. Subsequently, the patient was treated with intrathecal chemotherapy targeting the CNS. Despite aggressive treatment, CNS relapse remains a major concern due to the limited penetration of standard therapies into the CNS. This case underscores the importance of early recognition of CNS symptoms in CML patients, particularly in those with blast crisis, and highlights the need for tailored therapeutic strategies to manage this rare and challenging manifestation.

Purpose: This study aimed to compare the anxiety, depression, and quality of life (QOL) among caregivers of children with cerebral palsy and those caring for typically developing children. Methods: A cross-sectional, comparative study was conducted using convenience sampling to recruit 60 subjects. Anxiety, depression, and QOL were assessed with the Generalized Anxiety Disorder-7 Scale, the Patient Health Questionnaire-9, and the World Health Organization Quality of Life-BREF Scale, respectively. Results: The mean age of caregivers of children with cerebral palsy was 33.63±6.94 years, compared to 32±5.003 years for caregivers of typically developing children. Caregivers of children with cerebral palsy exhibited significantly higher levels of anxiety and depression, as well as poorer QOL, than those caring for typically developing children (P<0.05). Conclusion Caregivers of children with cerebral palsy experience higher levels of anxiety and depression and a poorer QOL compared to caregivers of typically developing children.

Purpose: This study aimed to compare the anxiety, depression, and quality of life (QOL) among caregivers of children with cerebral palsy and those caring for typically developing children. Methods: A cross-sectional, comparative study was conducted using convenience sampling to recruit 60 subjects. Anxiety, depression, and QOL were assessed with the Generalized Anxiety Disorder-7 Scale, the Patient Health Questionnaire-9, and the World Health Organization Quality of Life-BREF Scale, respectively. Results: The mean age of caregivers of children with cerebral palsy was 33.63±6.94 years, compared to 32±5.003 years for caregivers of typically developing children. Caregivers of children with cerebral palsy exhibited significantly higher levels of anxiety and depression, as well as poorer QOL, than those caring for typically developing children (P<0.05). Conclusion Caregivers of children with cerebral palsy experience higher levels of anxiety and depression and a poorer QOL compared to caregivers of typically developing children.