Prosthodontic Rehabilitation using Maxillary Fixed Dental Prosthesis with Tenon and Mortise Stress Breaker and Mandibular Complete Denture with Metal Reinforced Base: A Case Report The goal of restorative dentistry is to preserve teeth's natural structure and function while averting further issues with oral health. The most common treatment approach for rehabilitating one or two teeth is the insertion of a fixed dental prosthesis. This method offers a workable alternative for replacing lost teeth, and its longevity guarantees a long-term solution to prevent further oral health problems. To summarize, individuals with one or two missing teeth can have their smiles restored with a fixed dental prosthesis, which is a dependable, efficient, and effective method. To solve the prevalent problem of repeated prosthesis fractures, a single complete denture with a metal-reinforced base was utilised. This procedure offers a more durable and long-lasting solution for replacing lost natural teeth compared to traditional methods. This case study describes the thorough clinical treatment and fabrication of a pier abutment and metal denture base.

Prosthetic Rehabilitation of Edentulous Flabby Ridge using Modified Hobkirk Window Impression Technique: A Case Report Mobile denture-bearing tissues in the form of flabby ridges are susceptible to displacement under masticatory forces, leading to loss of peripheral seal. Conventional impression-making techniques may record the mobile tissue in a distorted state, adversely affecting the retention and stability of the definitive prosthesis. Hence, this case report describes a modified impression technique used to record the flabby edentulous ridge in an undisplaced state to avoid compression and rebounding of the mobile tissue. A 49-year-old male patient reported to the Department of Prosthodontics complaining of difficulty in chewing food due to missing teeth for the past one year. Intraoral examination revealed the healed edentulous ridges with flabby, displaceable tissue on the residual ridge crest with respect to the anterior segment in both maxillary and mandibular arches. Prosthetic rehabilitation using removable complete denture prosthesis was planned with definitive impressions made using modified Hobkirk technique. A modified impression technique used to record the flabby edentulous ridge in an undisplaced state to avoid compression and rebounding of the mobile tissue gave a satisfactory outcome. This technique is simple to implement and adheres to the principles of preventive prosthodontics. Periodic follow-up showed that the patient was satisfied with the prosthesis.

OBJECTIVEKanchnar guggulu is a compound Ayurvedic formulation used in clinical practice for the treatment of benign and malignant tumors. The present study investigates its cytotoxic and antiproliferative activities.

METHODSThe hydro-alcoholic (50%) extract of kanchnar guggulu was prepared. Its antimitotic activity was assessed in an Allium cepa assay, while its antiproliferative effects were studied in a yeast proliferation model. Methotrexate was used as a standard anticancer agent.

RESULTSIn the Allium assay, all concentrations of the extract (1, 2 and 3 mg/mL) and methotrexate (0.02 mg/mL) significantly inhibited the division of A. cepa root cells, decreasing root growth and mitotic index compared to control; this effect was concentration-dependent for kanchnar guggulu extract. In the antiproliferative studies, treatment with the hydro-alcoholic extract of kanchnar guggulu (1, 5 and 10 mg/mL) and methotrexate (0.025, 0.05 and 0.1 mg/mL) resulted in marked reduction of dividing Saccharomyces cerevisiae cells and inhibition of cell viability compared to control. The cytotoxicity of the hydro-alcoholic extract of kanchnar guggulu, shown by its antimitotic and antiproliferative effects, may be due to the presence of flavonoids and phenolics.

CONCLUSIONKanchnar guggulu exhibited a cytotoxic effect by inhibiting cell division (antimitotic) and reducing cell proliferation. These results substantiate its potential for the treatment of cancer and support its traditional use in the treatment of cancer.