Prosthodontic Rehabilitation using Maxillary Fixed Dental Prosthesis with Tenon and Mortise Stress Breaker and Mandibular Complete Denture with Metal Reinforced Base: A Case Report The goal of restorative dentistry is to preserve teeth's natural structure and function while averting further issues with oral health. The most common treatment approach for rehabilitating one or two teeth is the insertion of a fixed dental prosthesis. This method offers a workable alternative for replacing lost teeth, and its longevity guarantees a long-term solution to prevent further oral health problems. To summarize, individuals with one or two missing teeth can have their smiles restored with a fixed dental prosthesis, which is a dependable, efficient, and effective method. To solve the prevalent problem of repeated prosthesis fractures, a single complete denture with a metal-reinforced base was utilised. This procedure offers a more durable and long-lasting solution for replacing lost natural teeth compared to traditional methods. This case study describes the thorough clinical treatment and fabrication of a pier abutment and metal denture base.

Prosthetic Rehabilitation of Edentulous Flabby Ridge using Modified Hobkirk Window Impression Technique: A Case Report Mobile denture-bearing tissues in the form of flabby ridges are susceptible to displacement under masticatory forces, leading to loss of peripheral seal. Conventional impression-making techniques may record the mobile tissue in a distorted state, adversely affecting the retention and stability of the definitive prosthesis. Hence, this case report describes a modified impression technique used to record the flabby edentulous ridge in an undisplaced state to avoid compression and rebounding of the mobile tissue. A 49-year-old male patient reported to the Department of Prosthodontics complaining of difficulty in chewing food due to missing teeth for the past one year. Intraoral examination revealed the healed edentulous ridges with flabby, displaceable tissue on the residual ridge crest with respect to the anterior segment in both maxillary and mandibular arches. Prosthetic rehabilitation using removable complete denture prosthesis was planned with definitive impressions made using modified Hobkirk technique. A modified impression technique used to record the flabby edentulous ridge in an undisplaced state to avoid compression and rebounding of the mobile tissue gave a satisfactory outcome. This technique is simple to implement and adheres to the principles of preventive prosthodontics. Periodic follow-up showed that the patient was satisfied with the prosthesis.

Objective: Vascular Dementia (VaD), is associated with metabolic conditions. Diabetes is a major risk factor for the development of VaD. This study investigates the efficacy of ulinastatin (UTI) and sulforaphane (SUL) in streptozotocin (STZ)-diabetes induced vascular endothelium dysfunction and related dementia. Methods: Single dose STZ (50 mg/kg i.p.) was administered to Albino Wistar rats (male, 200−250 g). Morris water maze and attentional set shifting tests were used to assess the spatial learning, memory, reversal learning, and executive functioning in animals. Body weight, serum glucose, serum nitriteitrate, vascular endothelial function, aortic superoxide anion, brains’ oxidative markers (thiobarbituric acid reactive species-TBARS, reduced glutathione-GSH, superoxide dismutase-SOD, and catalase-CAT), inflammatory markers (IL-6, IL-10, TNF-, and myeloperoxidase-MPO), acetylcholinesterase activity-AChE, blood brain barrier (BBB) permeability and histopathological changes were also assessed. UTI (10,000 U/kg) and SUL (25 mg/kg) were used alone as well as in combination, as the treatment drugs. Donepezil (0.5 mg/kg) was used as a positive control. Results: STZ-administered rats showed reduction in body weight, learning, memory, reversal learning, executive functioning, impairment in endothelial function, BBB permeability, increase in serum glucose, brains’ oxidative stress, inflammation, AChE-activity, BBB permeability and histopathological changes. Administration of UTI and SUL alone as well as in combination, significantly and dose dependently attenuated the STZ-diabetes-induced impairments in the behavioral, endothelial, and biochemical parameters. Conclusion STZ administration caused diabetes and VaD which was attenuated by the administration of UTI and SUL.Therefore, these agents may be studied further for the assessment of their full potential in diabetes induced VaD.

Objective: Vascular Dementia (VaD), is associated with metabolic conditions. Diabetes is a major risk factor for the development of VaD. This study investigates the efficacy of ulinastatin (UTI) and sulforaphane (SUL) in streptozotocin (STZ)-diabetes induced vascular endothelium dysfunction and related dementia. Methods: Single dose STZ (50 mg/kg i.p.) was administered to Albino Wistar rats (male, 200−250 g). Morris water maze and attentional set shifting tests were used to assess the spatial learning, memory, reversal learning, and executive functioning in animals. Body weight, serum glucose, serum nitriteitrate, vascular endothelial function, aortic superoxide anion, brains’ oxidative markers (thiobarbituric acid reactive species-TBARS, reduced glutathione-GSH, superoxide dismutase-SOD, and catalase-CAT), inflammatory markers (IL-6, IL-10, TNF-, and myeloperoxidase-MPO), acetylcholinesterase activity-AChE, blood brain barrier (BBB) permeability and histopathological changes were also assessed. UTI (10,000 U/kg) and SUL (25 mg/kg) were used alone as well as in combination, as the treatment drugs. Donepezil (0.5 mg/kg) was used as a positive control. Results: STZ-administered rats showed reduction in body weight, learning, memory, reversal learning, executive functioning, impairment in endothelial function, BBB permeability, increase in serum glucose, brains’ oxidative stress, inflammation, AChE-activity, BBB permeability and histopathological changes. Administration of UTI and SUL alone as well as in combination, significantly and dose dependently attenuated the STZ-diabetes-induced impairments in the behavioral, endothelial, and biochemical parameters. Conclusion STZ administration caused diabetes and VaD which was attenuated by the administration of UTI and SUL.Therefore, these agents may be studied further for the assessment of their full potential in diabetes induced VaD.

Background: The most frequent complication of nasotracheal intubation (NTI) is epistaxis. Epinephrine nasal gauze packing has been used conventionally as a pre-treatment for reducing epistaxis, but it carries a disadvantage of pain and anxiety in patients. However, xylometazoline drops are easier to administer and more convenient for patients. We aimed at comparing the effectiveness of xylometazoline drops and epinephrine merocele packing in reducing bleeding and postoperative complications in our population. Methods: Our study enrolled 120 patients in a double-blind randomized controlled trial. We randomly allocated ASA1 or 2 adult patients into 2 groups: Group X and Group E. Group X received 0.1% xylometazoline nasal drops, and epinephrine (1:10,000) merocele nasal packing was used in Group E. The primary outcome was the incidence of bleeding during NTI; the severity of bleeding, navigability, bleeding during extubation, and postoperative complications were secondary outcomes. We used IBM SPSS and Minitab software for statistical analysis, and P < 0.05 was considered statistically significant. Results: We analyzed the data of 110 patients: 55 in Group X and 55 in Group E. The two groups did not have different bleeding incidence (56.4% vs 60.0%; P = 0.70); however, the incidence of severe bleeding was less with xylometazoline than with epinephrine (3.63% vs 14.54%; P < 0.05). We also observed less bleeding during extubation (38.2% vs 68.5%; P < 0.05) with xylometazoline. Other secondary outcomes were akin to both groups. Conclusion The incidence of severe and post-extubation bleeding was significantly less with xylometazoline.Hence, it may be an effective alternative for reducing the incidence and severity of epistaxis during NTI.