Objective:Exploring the difference of the prefrontal cortex activation between Unipolar Depression(UD) and Bipolar Depression(BD).Methods:The changes of oxygenated hemoglobin concentration in the prefrontal lobe of 69 patients with UD and 68 patients with BD under verbal fluency task were collected and compared by Near-Infrared Spectroscopy (NIRS) and the correlation between the scores of the Hamilton Depression Scale (HAMD) and the function of the subject′s prefrontal cortex was analyzed by partial correlation analysis.Results:There were significant differences in oxygenated hemoglobin concentration changes in the left dorsolateral prefrontal cortex, bilateral ventrolateral prefrontal cortex and bilateral orbitofrontal cortex ( P<0.05) between the UD and BD group. And the oxygenated hemoglobin concentration changes in the right dorsolateral prefrontal cortex was correlated with the severity of depressive symptoms in both the BD and UD groups ( P<0.05), while the oxygenated hemoglobin concentration changes in the left dorsolateral prefrontal cortex was only associated with the severity of depressive symptoms in the UD group. Conclusion:There are significant differences in activation of the lateral prefrontal cortex and orbitofrontal cortex between the patients with BD and UD, and in BD patients, the correlation of the cortex activation and the severity of depressive symptoms is different between the left dorsolateral prefrontal cortex and the right dorsolateral prefrontal cortex.

Objective:Exploring the difference of the prefrontal cortex activation between Unipolar Depression(UD) and Bipolar Depression(BD).Methods:The changes of oxygenated hemoglobin concentration in the prefrontal lobe of 69 patients with UD and 68 patients with BD under verbal fluency task were collected and compared by Near-Infrared Spectroscopy (NIRS) and the correlation between the scores of the Hamilton Depression Scale (HAMD) and the function of the subject′s prefrontal cortex was analyzed by partial correlation analysis.Results:There were significant differences in oxygenated hemoglobin concentration changes in the left dorsolateral prefrontal cortex, bilateral ventrolateral prefrontal cortex and bilateral orbitofrontal cortex ( P<0.05) between the UD and BD group. And the oxygenated hemoglobin concentration changes in the right dorsolateral prefrontal cortex was correlated with the severity of depressive symptoms in both the BD and UD groups ( P<0.05), while the oxygenated hemoglobin concentration changes in the left dorsolateral prefrontal cortex was only associated with the severity of depressive symptoms in the UD group. Conclusion:There are significant differences in activation of the lateral prefrontal cortex and orbitofrontal cortex between the patients with BD and UD, and in BD patients, the correlation of the cortex activation and the severity of depressive symptoms is different between the left dorsolateral prefrontal cortex and the right dorsolateral prefrontal cortex.

Objective To explore the characteristics of prefrontal cortex activation by near?infrared spectroscopy (NIRS) in depressed patients who also had suicide ideation or committed suicide. Methods Total 23 patients who suffered major depression disorder (MDD) complicated with suicide behavior (suicide behavior group), 28 MDD patients bearing suicide ideation without behavior (suicide ideation group), and 26 healthy controls, matched with the gender, age, and education, were tested by category verbal fluency task (VFT). During the task, 52?channel FOIRE?3000 of Shimadzu was used to collect the relative concentration of oxygenate hemoglobin (Oxy?Hb) from all three groups. Results There was no significant difference between suicide behavior group and suicide idea group in their VFT performance (F=11.196, P>0.05), which however were both lower than the healthy control group (P<0.05);the Oxy?Hb exchange of the bilateral orbitofrontal cortex and bilateral dorsolateral prefrontal cortex in suicide behavior group and the suicide idea group were significantly lower than the healthy control group (P<0.05). Conclusion The activity of the prefrontal cortex in MDD patients who had suicide ideation or committed suicide is significantly lower with the most prominent change found in bilateral orbitofrontal cortex and bilateral dorsolateral prefrontal cortex.

Objective To explore the characteristics of prefrontal cortex activation by near?infrared spectroscopy (NIRS) in depressed patients who also had suicide ideation or committed suicide. Methods Total 23 patients who suffered major depression disorder (MDD) complicated with suicide behavior (suicide behavior group), 28 MDD patients bearing suicide ideation without behavior (suicide ideation group), and 26 healthy controls, matched with the gender, age, and education, were tested by category verbal fluency task (VFT). During the task, 52?channel FOIRE?3000 of Shimadzu was used to collect the relative concentration of oxygenate hemoglobin (Oxy?Hb) from all three groups. Results There was no significant difference between suicide behavior group and suicide idea group in their VFT performance (F=11.196, P>0.05), which however were both lower than the healthy control group (P<0.05);the Oxy?Hb exchange of the bilateral orbitofrontal cortex and bilateral dorsolateral prefrontal cortex in suicide behavior group and the suicide idea group were significantly lower than the healthy control group (P<0.05). Conclusion The activity of the prefrontal cortex in MDD patients who had suicide ideation or committed suicide is significantly lower with the most prominent change found in bilateral orbitofrontal cortex and bilateral dorsolateral prefrontal cortex.

Objective To investigate the difference of brain activation patterns between depression patients and normal persons by near-infrared spectroscopy imaging.Methods Totally 14 depressed patients and 13 sex,age,and education matched healthy controls were required to perform category verbal fluency task (VFT).The relative concentration of deoxygenate hemoglobin and oxygenate hemoglobin was collected by a 45-channel instrument,and the data was processed with the software of Statistical Parametric Mapping (SPM).Results The task performances were not significantly different between the two groups,the average curve of oxygenate hemoglobin and deoxygenate hemoglobin were lower in depressed patients with significant difference in dorsolateral prefrontal cortex.For instance,the oxygenate change in Channel 38 and Channel 41 was Deoxy-Hb(t =3.29,3.47),Oxy-Hb (t =3.18,4.03),P ＜ 0.10.Conclusion The activation in bilateral dorsolateral prefrontal cortex may be lower in depression patients compared to control group.

Objective To investigate the difference of brain activation patterns between depression patients and normal persons by near-infrared spectroscopy imaging.Methods Totally 14 depressed patients and 13 sex,age,and education matched healthy controls were required to perform category verbal fluency task (VFT).The relative concentration of deoxygenate hemoglobin and oxygenate hemoglobin was collected by a 45-channel instrument,and the data was processed with the software of Statistical Parametric Mapping (SPM).Results The task performances were not significantly different between the two groups,the average curve of oxygenate hemoglobin and deoxygenate hemoglobin were lower in depressed patients with significant difference in dorsolateral prefrontal cortex.For instance,the oxygenate change in Channel 38 and Channel 41 was Deoxy-Hb(t =3.29,3.47),Oxy-Hb (t =3.18,4.03),P ＜ 0.10.Conclusion The activation in bilateral dorsolateral prefrontal cortex may be lower in depression patients compared to control group.

Objective: To investigate socialdemological factors,mental stress and dysthymia and their relationship with Cesarean section in normal city primipara.Methods: In a prospective observational study,200 normal city primipara were followed up longitudinally from 36 pregnancy weeks to labor.Their socialdemological factors were recorded,the level of mental stress and dysthymia were measured in late pregnancy by the self-made pregnanced women's questionaires and CES-D,mode of delivery was also recorded.Results: The occurrence rate of dysthymia among normal city pregnanced women was 28%.Age,educational level,family's mensal income,attendance of maternity school,friends and relatives with unfavorable delivery,mental preparation for delivery,relationship with husband and uneasiness about newborns' health were related significantly to the occurrence rate of dysthymia(P

Objective: To evaluate the depression and anxiety in patients with sleep apnea-hypopnea syndrome (SAHS). Methods: Fifty patients with SAHS were diagnosed with polysomnography (PSG) and 30 healthy controls underwent whole-night PSG monitory and evaluated by Zung Self-rating Depression Scale (SDS) and Zung Self-rating Anxiety Scale (SAS). Results: The total scores of SAS and SDS in SAHS group were significantly higher than those in control group ( P