Liposarcoma is a common soft tissue malignant tumor with multiple histological types,among which well-differenti-ated liposarcoma and dedifferentiated liposarcoma are the largest subgroups of liposarcoma.After conventional treatment,the 5-year survival rate of patients with dedifferentiated liposarcoma has not been significantly improved.In recent years,immunotherapy has shown significant efficacy in tumors such as melanoma and lung cancer,and has been widely studied in well-differentiated liposarcoma and dedifferentiated liposarcoma.This article summarizes the clinical and genetic features of well-differentiated liposarcoma and dedi-fferentiated liposarcoma,conventional treatment methods,and the application of immunotherapy in liposarcoma,including immune checkpoint inhibitors,adoptive cell therapy,oncolytic viruses,cancer vaccines,and immunotherapy combined with other treatment op-tions.Integrating immune-related treatment options for liposarcoma is an urgent problem to be solved,and it also provides broad ideas for clinical work to understand liposarcoma and new management and treatment strategies.