Background: : Going to the health service for antenatal help the newborn to be healthy and to reduce the risk factors, especially to reduce the low weight and to help the mother to understand how to live, such as the belief in the consumption of various foods, exercise, rest and behavior. At the same time, customs and social support, especially from the family support, are important in understanding health problems. Objective: : To study the attitude and family support in antenatal the wife's in the Makrong ethnicity in Boualapha District, Khammouane Province, Lao PDR. Methodology: : This was cross-sectional study. Data collection by using questionnaire form by interview face-to-face. The data entered by Epi-data and analysis by SPSS program. Result: : A total of 265 participants, most of them had between 18-35 years old (57.36%), are farmers (76.98%), and have completed primary education (40.75%). Most of the participants were married less than 5 years (85.66%) and the number of pregnancies was less than 3 times (63.77%), and the monthly income was <500,000 kip (63.77%). Most of the participants (54.72%) had a positive attitude towards going to the antenatal of their wife, the most source of information is from medical staff (92.02%), talking about health and children (71.85%). For supporting the wife to go to the antenatal, almost all participants agreed (96.28%). Analysis of the association significant found that farmer is to agree his wife to had an antenatal (p-value: <0.001) and those with an income of less than 500,000 kip (p-value: 0.004). In addition, those who did not finish primary school had a positive attitude about going to the antenatal (p-value: 0.001), those who were farmers (p-value: 0.001) and those who had an income of less than 500,000 kip (p-value: 0.008). Conclusion: More than half of the participant has a positive attitude towards the wife's antenatal visit and almost all of them support the wife to go antenatal at the health service facility, most of them received information from the medical staff talking about the health of the mother and child. The results of the study indicate that there are a number of wife who do not go to have an antenatal. Therefore, more health education should be given to couples about the benefits of having an antenatal to encourage 100% of wife’s to have an antenatal.