Toxoplasmosis, a zoonotic disease caused by the obligate intracellular parasite Toxoplasma gondii, is widely prevalent across the world. The life cycle of T. gondii involves definitive hosts (cats and felines), intermediate hosts (humans, livestock, and wild animals), and the environment (such as soil and water). The One Health concept brings together the health of humans, animals, and the environment, with aims to pursue the optimal health outcomes through coordinated management. Management of toxoplasmosis from a One Health perspective may provide key insights into formulation of interventions for toxoplasmosis control. This article reviews the complex biological characteristics and life cycle of T. gondii, as well as the importance of felines as definitive hosts in the transmission of toxoplasmosis, analyzes the epidemiology, ecological impact and economic burden of toxoplasmosis, and discusses the bottlenecks in diagnostic and monitoring systems, environmental management technologies, and One Health interdisciplinary collaboration. In addition, toxoplasmosis control strategies are proposed based on the One Health concept, covering public health interventions, management of animal sources, multi-sector collaboration, and development of novel vaccines. These strategies provide insights into interruption of toxoplasmosis transmission and maintenance of the global public health security.

Objective To explore the mediating effect of mental toughness and perceived social support on the relationship between psychological state and nursing compliance in patients with gastrointestinal polyps.Methods A cross-sectional study was conducted on 106 patients with gastrointestinal polyps treated in the Sixth Medical Center of the PLA General Hospital from October 2020 to March 2022 using convenient sampling method.A self-made general data questionnaire was used to conduct a questionnaire survey.Pearson correlation analysis was used to analyze the correlation between psychological toughness,perceived social support,psychological status and nursing compliance in patients with gastrointestinal polyps.The mediating effect of mental toughness and perceived social support on psychological status and nursing compliance in patients with gastrointestinal polyps was investigated.Results After excluding 4 invalid questionnaires,102 valid questionnaires were finally obtained,and the effective response rate was 96.23%.The nursing compliance score in the patients with family history was higher than that in those without family history(P<0.05).Pearson correlation analysis showed that depression in mental state was significantly negatively correlated with mental toughness,perceived social support,and nursing compliance(r=-0.786,P<0.001;r=-0.559,P<0.001;r=-0.791,P<0.001);anxiety was significantly negatively correlated with mental toughness,perceived social support,and nursing compliance(r=-0.825,P<0.001;r=-0.580,P<0.001;r=-0.829,P<0.001).The mediating effect analysis showed that psychological state(depression,anxiety)as a direct effect had no significant effect on the nursing compliance of patients with gastrointestinal polyps(P>0.05),and psychological toughness and perceived social support had an impact on nursing compliance through the mediating effect(P<0.05).Conclusion Mental toughness and perceptive social support are significantly correlated with mental state and nursing compliance of patients with gastrointestinal polyps.Mental state can ultimately affect nursing compliance by affecting patients'mental toughness and perceptive social support ability.

Mercury is one of the common heavy-metal toxins,which can cause damage throughout the body in a variety of ways. Cases of renal toxicity of mercury poisoning are increasing clinically. However,little is known about nephrotoxicity mechanisms,and treatment remains unsatisfactory. The mechanism of mercury toxic nephropathy is reviewed in this paper,including the direct toxic effect on the kidney,the injury to the biomembrane system,generation of Hg-metallothionein,imbalance of intra?cellular calciumion,oxidative damage,induced apoptosis,and immune injury. Besides,the mechanism and limitation of common therapies,potential developments of the field are discussed. This review will facilitate further investigations therapies about both the mechanism and treatment of mercury toxic nephropathy.