OBJECTIVE To investigate the prevalence and influencing factors of potentially inappropriate medication （PIM） among the elderly in nursing homes in Urumqi based on three PIM screening tools， and to compare the applicability of different tools. METHODS A cross-sectional study design was adopted. Elderly individuals from six nursing homes in Urumqi were selected as the research subjects from May 2021 to September 2023. Demographic characteristics， disease burden and medication records of the elderly were collected. PIM screening was performed using the Chinese PIM criteria （2024 edition）， the American Geriatrics Society （AGS） Beers criteria （2023 edition）， and the Screening Tool of Older Person’S Prescriptions（STOPP）/Screening Tool to Alert to Right Treatment（START） （2023 edition）. Fleiss’s Kappa test was used to assess the consistency among the three screening tools， and multivariate Logistic regression was used to analyze the influencing factors of PIM. RESULTS The prevalence of PIM screened by the Chinese PIM criteria was 47.4% （323/682）， by the AGS Beers criteria was 43.4% （296/682）， and by the STOPP criteria was 50.9% （347/682）. The consistency among the three screening tools was low （Fleiss’s Kappa＝0.12， P ＜0.001）. Multivariate Logistic regression analysis showed that all three screening tools indicated that polypharmacy， aspirin use and psychotropic drug use were independent risk factors for PIM among elderly in nursing houses （all OR＞1， P ＜0.05）. CONCLUSIONS The prevalence of PIM among the elderly in nursing homes in Urumqi is relatively high. Polypharmacy， aspirin use and psychotropic drug use are common independent risk factors for PIM. There are differences in screening results among the three tools with low consistency. The Chinese PIM criteria can serve as a first-line tool for PIM screening in nursing homes.

On the occasion of the 110th Anniversary of the establishment of the Chinese Medical Association, the third conference of the Fourth Editorial Board of Chinese Journal of Digestive Surgery, and the Second Elite Group of Chinese Journal of Digestive Surgery, was successfully held in Kunming on July 4, 2025. This conference systematically summarizes the development experience of the journal over the past 20 years from three aspects: the role of ecological construction of thought in the discipline construction of digestive surgery, the display of the latest academic achievements in the field of digestive surgery, the development difficulties, and breakthrough paths of the discipline, and strategically plans the path of discipline construction in the new era.

Objective To investigate whether successful percutaneous coronary intervention(PCI)could improve symptoms and quality of life(QOL)in left main disease and/or 3-vessel disease patients with diabetes.Methods Patients with left main disease and/or 3-vessel disease who underwent PCI in the First Affiliated Hospital of Air Force Medical University from April 2018 to May 2021 were consecutively enrolled and subdivided into 2 groups:diabetes and no diabetes.Detailed baseline characteristics,symptoms,including dyspnea and angina,assessed with the Rose dyspnea scale(RDS),Seattle angina questionnaire(SAQ),the European quality of life-5 dimensions(EQ-5D)and 12-item short-form health survey(SF-12)questionnaire respectively,procedural details,and 1 month and 1 year follow-up data were collected.Results Among 440 left main disease and/or 3-vessel disease patients,disease was present in 176(40.00％),who had more hypertension,peripheral artery disease,and LCX lesion(all P＜0.05).The incidence of major adverse cardiovascular events(MACE)and all-cause mortality were similar between the two groups(both P＞0.05)at 1 month follow-up,while all-cause mortality in diabetes patients was significantly higher than those without diabetes at 1 year follow-up(P=0.013).Low left ventricular ejection fraction was an independent risk factor for MACE and all-cause mortality at 1 month and 1 year follow-up after successful revascularization(all P＜0.05).Most importantly,symptoms,including dyspnea and angina,and QOL were markedly improved regardless of diabetes both at 1 month and 1 year follow-up(all P＜0.05).Diabetes patients showed improved dyspnea and QOL at similar degree to the non-diabetes patients(all P＞0.05)and a more significantly relieved angina(P=0.013).Additionally,the number of chronic total occlusion(CTO)per patient was identified as an independent risk factor of dyspnea(OR 0.723,95％CI 0.525～0.997,P=0.048)and angina relief(OR 0.686,95％CI 0.473～0.995,P=0.047),and the contrast volume(OR 0.995,95％CI 0.992～0.999,P=0.008)as an independent risk factor of QOL improvement in diabetic patients.Conclusions Successful PCI is beneficial for relieving symptoms and improving quality of life in patients with diabetes who have left main disease and/or 3-vessel disease.

AIM To investigate the clinical effects of Supplemented Gegen Qinlian Decoction combined with acupuncture on patients with ulcerative colitis of Large Intestinal Dampness-heat Pattern.METHODS One hundred and twenty patients were randomly assigned into control group(60 cases)for 1-month administration of Pefikang Capsules and Mesalazine Sustained Release Granules,and observation group(60 cases)for 1-month administration of Supplemented Gegen Qinlian Decoction,acupuncture,Pefikang Capsules and Mesalazine Sustained Release Granules.The changes in clinical effects,symptom remission time,TCM syndrome scores,Geboes index,lesion activity index,Baron score,inflammatory factors(IL-6,IL-8,TNF-α),immune function indices(IgA,IgG,IgM),IBDQ score and recurrence rate were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05),along with shorter symptom remission time(P＜0.05)and lower recurrence rate(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,Geboes index,lesion activity index,Baron score,inflammatory factors,IgG,IgM(P＜0.05),and increased IBDQ score(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients with ulcerative colitis of Large Intestinal Dampness-heat Pattern,Gegen Qinlian Decoction combined with acupuncture can improve clinical symptoms,promote disease recovery,enhance immune functions and life quality,and reduce recurrence rate.

Objective:To test the validity and reliability of the Chinese version of the Peer Mental Health Stig-matization Scale-Revised(PMHSS-R)in middle school students.Methods:A total of 1 099 middle school students were selected and randomly divided into Sample 1(n=549)and Sample 2(n=550)for exploratory factor analysis and confirmatory factor analysis,respectively.The total sample(n=1 099)was used to measure internal consisten-cy,and 87 of them were retested two weeks later.A total of 259 middle school students(Sample 3)was selected for the criterion validity test with the Depression Stigma Scale(DSS)and the Attitudes toward Seeking Professional Psychological Help Scale-Short Form(ATSPPH-SF).Results:Exploratory factor analysis identified 2 common fac-tors,namely stigma awareness and stigma agreement,with a cumulative variance contribution rate of 66.86％.The confirmatory factor analysis showed that the two-factor structure model fit was adequate(x2/df=3.70,CFI=0.97,TLI=0.96,SRMR=0.03,RMSEA=0.07).The PMHSS-R Chinese version scores were positively correlated with the DDS scores(ICC=0.58,P＜0.01)and negatively correlated with the ATSPPH-SF scores(ICC=-0.40,P＜0.01).The Cronbach α coefficients of the total scores and the two-factor scores were 0.90,0.92,0.85,respective-ly.The test-retest reliability coefficients(ICC)were 0.84,0.76,0.78,respectively.Conclusion:The Chinese ver-sion of the Peer Mental Health Stigmatization Scale-Revised(PMHSS-R)demonstrates good validity and reliability in assessing mental health stigma among middle school students.

Objective:To test the validity and reliability of the Chinese version of the Peer Mental Health Stig-matization Scale-Revised(PMHSS-R)in middle school students.Methods:A total of 1 099 middle school students were selected and randomly divided into Sample 1(n=549)and Sample 2(n=550)for exploratory factor analysis and confirmatory factor analysis,respectively.The total sample(n=1 099)was used to measure internal consisten-cy,and 87 of them were retested two weeks later.A total of 259 middle school students(Sample 3)was selected for the criterion validity test with the Depression Stigma Scale(DSS)and the Attitudes toward Seeking Professional Psychological Help Scale-Short Form(ATSPPH-SF).Results:Exploratory factor analysis identified 2 common fac-tors,namely stigma awareness and stigma agreement,with a cumulative variance contribution rate of 66.86％.The confirmatory factor analysis showed that the two-factor structure model fit was adequate(x2/df=3.70,CFI=0.97,TLI=0.96,SRMR=0.03,RMSEA=0.07).The PMHSS-R Chinese version scores were positively correlated with the DDS scores(ICC=0.58,P＜0.01)and negatively correlated with the ATSPPH-SF scores(ICC=-0.40,P＜0.01).The Cronbach α coefficients of the total scores and the two-factor scores were 0.90,0.92,0.85,respective-ly.The test-retest reliability coefficients(ICC)were 0.84,0.76,0.78,respectively.Conclusion:The Chinese ver-sion of the Peer Mental Health Stigmatization Scale-Revised(PMHSS-R)demonstrates good validity and reliability in assessing mental health stigma among middle school students.

Soy is a vital source of plant carbohydrates.However,it poses significant allergenic risks,particularly to young children and animals.Among the various proteins in soy,β-conglycinin,which con-stitutes approximately 30％of total soy carbohydrates,is a primary allergen.Undigested β-conglycinin can lead to intestinal damage by inhibiting cell growth,disrupting the cytoskeleton,and inducing apopto-sis.It can also enter the lymphatic and circulatory systems,triggering allergic reactions.Conventional ELISA methods for detecting β-conglycinin rely on polyclonal or monoclonal antibodies,which are limited by their large molecular weight,difficulty in accessing the protein core,and sensitivity to acidic and bas-ic conditions.To address these limitations,this study aimed to develop nanobodies(Nbs)against β-con-glycinin.Nbs,derived from the variable regions of heavy-chain antibodies found in camelids,have a mo-lecular weight approximately one-tenth that of conventional antibodies.They offer advantages such as small size,stable structure,high specificity,and strong affinity.A female alpacas was immunized five times using β-conglycinin,which showed a heavy chain antibody potency of 1∶16 000 by ELISA.Pe-ripheral blood lymphocytes were subsequently isolated and total RNA was extracted.The variable region of the heavy-chain antibody was amplified via PCR,and recombinant plasmids were constructed and transformed into the E.coli competency strain ER2738.The resulting library contained about 3.5×108 CFU/mL,which increased to 1.15×1012 PFU/mL after phage rescue,with a 100％Nbs gene insertion rate,indicating high diversity.Its Nbs phage output was significantly enriched by four rounds of solid-phase elution with an enrichment rate of 155.9.Four rounds of solid-phase panning yielded 35 positive clones,all of which shared the same amino acid sequence upon sequencing.The selected Nb was ex-pressed in a prokaryotic system,and its binding ability to β-conglycinin was confirmed using Western blotting and ELISA.The results demonstrated excellent specificity and affinity.This research lays the groundwork for developing a rapid and efficient detection method for β-conglycinin using Nbs,potentially enhancing food safety and allergen management.

Objective:To explore the effect and safety profile of psycho-cardiology model combined with phased re-habilitation exercise on psychological state,cardiac function,sleep quality,cognitive function and quality of life of patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods:This ran-domized controlled study enrolled 150 CHD patients with anxiety and sleep disorder who underwent PCI in the Psy-cho-cardiology Medical Center of Beijing Anzhen Hospital,Capital Medical University between January 2023 and April 2023.Patients were randomly divided into control group(n=75)and intervention group(n=75).Patients in the control group received routine management mode intervention after PCI,comparing to those in the intervention group receiving psycho-cardiology model combined with phased rehabilitation exercise intervention after PCI.Both groups were intervened for 2 months and followed up for 6 months.Mental state,heart function,sleep quality,cog-nitive function,quality of life and incidence of adverse events were compared between two groups.Results:Com-pared to those in control group,patients in intervention group had significant lower scores of generalized anxiety dis-order-7(GAD-7)[(5.16±1.19)points vs.(7.53±1.68)points],patient health questionaire-9(PHQ-9)[(7.63±1.03)points vs.(10.41±1.54)points],Athens insomnia scale(AIS)[(3.69±1.35)points vs.(6.43±2.11)points]and left ventricular end diastolic diameter(LVEDd)[(44.50±2.86)mm vs.(54.11±3.46)mm](P＜0.001 all),and significant higher left ventricular ejection fraction(LVEF)[(60.06±3.05)％vs.(53.90±3.05)％],scores of Seattle angina questionnaire(SAQ)[(83.31±6.59)points vs.(52.75±5.66)points]and mini-mental state examination(MMSE)[(26.44±4.68)points vs.(23.23±4.01)points](P＜0.001 all).We detec-ted significant lower incidence of adverse events in intervention group compared to control group(4.29％vs.16.44％,P=0.018).Conclusion:Psycho-cardiology model combined with phased rehabilitation exercise may im-prove psychological state,heart function,sleep quality,cognitive function and quality of life in CHD patients with anxiety and sleep disorder after PCI with considerable safety.

AIM To investigate the clinical effects of Supplemented Gegen Qinlian Decoction combined with acupuncture on patients with ulcerative colitis of Large Intestinal Dampness-heat Pattern.METHODS One hundred and twenty patients were randomly assigned into control group(60 cases)for 1-month administration of Pefikang Capsules and Mesalazine Sustained Release Granules,and observation group(60 cases)for 1-month administration of Supplemented Gegen Qinlian Decoction,acupuncture,Pefikang Capsules and Mesalazine Sustained Release Granules.The changes in clinical effects,symptom remission time,TCM syndrome scores,Geboes index,lesion activity index,Baron score,inflammatory factors(IL-6,IL-8,TNF-α),immune function indices(IgA,IgG,IgM),IBDQ score and recurrence rate were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05),along with shorter symptom remission time(P＜0.05)and lower recurrence rate(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,Geboes index,lesion activity index,Baron score,inflammatory factors,IgG,IgM(P＜0.05),and increased IBDQ score(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients with ulcerative colitis of Large Intestinal Dampness-heat Pattern,Gegen Qinlian Decoction combined with acupuncture can improve clinical symptoms,promote disease recovery,enhance immune functions and life quality,and reduce recurrence rate.

To formulate an expert consensus on the principles of preoperative hair removal and provide scientific guidance for standardized removal of hair before surgical procedures so as to reduce the incidence of surgical site infections.METHODS Led by the Hospital Management Institute of National Health Commission of the People's Republic of China,this consensus was reached with the joint efforts from the expects of relevant fields such as surgeries,interventional therapies,nursing,and infection prevention and control.The consensus facilitates the classification and evaluation of literatures by following the evidence grade formulated by Oxford Evidence-based Medicine Center and focuses on the association of preoperative hair removal with surgical site infection,it reaches the evidence grade of expert consensus and recommendation intensity by integrating with discussions on meetings and clinical experience of the expects from relevant fields.RESULTS A total of 6 items of consensus were reached by summarizing the latest evidence on the aspects including the indications for preoperative hair removal,tools,range,timing and places.CONCLUSION The consensus,to some extent,make supplements to and complete the exiting regulations and standards.It provides guidance for the medical institutions to carry out the preoperative hair removal.