The transcription factor HOXB13 plays crucial roles in cancer development. HOXB13 is abnormally expressed in most cancers, which makes it a valuable therapeutic target for cancer therapy. The level of HOXB13 differs significantly between healthy and cancer tissues, which indicates that the level of HOXB13 is closely related to carcinogenesis. The regulatory network mediated by HOXB13 in cancer proliferation, metastasis, and invasion has been systematically investigated. Moreover, HOXB13 variants play distinct roles in different cancers and populations. By understanding the molecular mechanisms and mutation features of HOXB13, we provide a comprehensive overview of carcinogenesis networks dependent on HOXB13. Finally, we discuss advancements in anticancer therapy targeting HOXB13 and the roles of HOXB13 in drug resistance to molecular-targeted therapies, which serves as a foundation for developing HOXB13-targeted drugs for clinical diagnosis and cancer therapies.
Humans ; Neoplasms/metabolism* ; Homeodomain Proteins/metabolism* ; Carcinogenesis/genetics* ; Mutation ; Gene Expression Regulation, Neoplastic ; Molecular Targeted Therapy ; Drug Resistance, Neoplasm/genetics*

The training of residents majoring in ultrasound needs not only to pay attention to the teaching of speculative knowledge,but also to "look at pictures and talk",which is based on a large number of diagnostic ultrasound cases,training the residents to find,discover and discriminate the lesions from the ultrasonic images to finally form a sharp recognition and diagnosis ability.This study used the instant messaging tool WeChat to establish a virtual learning platform and implement a case based teaching process through this platform,which can avoid the limitations of time and space,and make the communication between teachers and students faster.According to the questionnaire survey,residents generally believed that the training mode can effectively improve learning efficiency and professional ability and hope to add this training mode to the basis of traditional teaching mode.The results of resident case analysis showed that the diagnostic accuracy of residents gradually increased during the training process.The model of WeChat platform combined with case teaching can provide new ideas and methods for standardized training of resident doctors in ultrasound specialty.

Objective To discuss the relationship between physical activity (PA),health related quality of life (HRQOL) and depression among community dwelling and institutionalized elderly.Methods YPAS,SF-36 and GDS were used to investigate physical activity,HRQOL and depression in 436 elderly (58％ community-dwellers and 42％ institutionalized),and their relationship was analyzed.Results Physical activity time of elderly was (40.5 ± 1.2) h in the community and (35.2 ± 0.5) h in the institutions,and the difference was statistically significant (F =26.9,P ＜ 0.01).The psychical score and psychological score in SF-36 were (66.3 ± 0.9) and (63.5 ± 0.8) in community elderly,higher than (56.3 ±0.8) and(51.3 ± 0.7)in institutionalized elderly,and the differences were statistically significant (t =4.7,3.9,respectively;P ＜0.01).11.1％ of elderly in community and 18.5％ of institutionalized elderly had moderate depression,and the difference was statistically significant (x2 =3.9,P ＜ 0.05).There was no statistically significant difference of severe depression rate between two groups (x2 =6.5,P ＞ 0.05).HRQOL of elderly,except for emotional function,had positive relationship with PA (r =0.108-0.255,P ＜ 0.01),and depression score had positive relationship with YPAS score and weekly energy cost (r =0.156,0.121,respectively; P ＜ 0.05).Conclusions Physical activity is significantly related to both physical and psychological dimensions in HRQOL,and QA has positive effect on both community-dwelling and institutionalized elderly.