Objective:To systematically synthesize qualitative studies on healthcare professionals' experiences and needs regarding telemedicine services for diabetic foot ulcers (DFU), and to provide scientific evidence for further improvement of DFU telemedicine service systems.Methods:PubMed, Web of Science, Cochrane Library, CINAHL, Scopus, Embase, ProQuest, PsycINFO, China National Knowledge Infrastructure, Wanfang Data, VIP, and China Biology Medicine disc were searched for qualitative studies on healthcare professionals' experiences and needs in the process of constructing and using DFU telemedicine service platforms. The time limit was from the inception of the databases to December 2024. The included literature was appraised according to the 2016 Joanna Briggs Institute (JBI) critical appraisal checklist for qualitative research, and the results were integrated and summarized using meta-aggregation.Results:A total of 10 studies were included, from which 30 findings were extracted, forming 11 categories, and were synthesized into four integrated findings: healthcare professionals held divergent attitudes toward DFU telemedicine services, perceived multiple benefits, faced many challenges, and had multidimensional needs.Conclusions:Telemedicine services have provided healthcare professionals with great convenience in managing DFU patients, but challenges still exist. In the future, relevant platforms and systems should be continuously improved by integrating the needs of healthcare professionals and patients, while service processes and management mechanisms should be enhanced to improve the quality of telemedicine services.

Objective:To systematically synthesize qualitative studies on healthcare professionals' experiences and needs regarding telemedicine services for diabetic foot ulcers (DFU), and to provide scientific evidence for further improvement of DFU telemedicine service systems.Methods:PubMed, Web of Science, Cochrane Library, CINAHL, Scopus, Embase, ProQuest, PsycINFO, China National Knowledge Infrastructure, Wanfang Data, VIP, and China Biology Medicine disc were searched for qualitative studies on healthcare professionals' experiences and needs in the process of constructing and using DFU telemedicine service platforms. The time limit was from the inception of the databases to December 2024. The included literature was appraised according to the 2016 Joanna Briggs Institute (JBI) critical appraisal checklist for qualitative research, and the results were integrated and summarized using meta-aggregation.Results:A total of 10 studies were included, from which 30 findings were extracted, forming 11 categories, and were synthesized into four integrated findings: healthcare professionals held divergent attitudes toward DFU telemedicine services, perceived multiple benefits, faced many challenges, and had multidimensional needs.Conclusions:Telemedicine services have provided healthcare professionals with great convenience in managing DFU patients, but challenges still exist. In the future, relevant platforms and systems should be continuously improved by integrating the needs of healthcare professionals and patients, while service processes and management mechanisms should be enhanced to improve the quality of telemedicine services.

Objective To investigate correlations of the ratio of specific brain region volume to total brain volume(ratio％),standard uptake value(SUV)of specific brain region based on 18F-FDG PET/MR examination in Alzheimer disease(AD)patients,as well as the relationship between changes of these two.Methods Fifty AD patients were retrospectively collected.Based on FDG PET/MR,the ratio％and the mean SUV(SUVmean)of 40 specific brain regions were obtained,and the correlation between ratio％and SUVmean for each region were evaluated.According to a database of normal brains,Z-scores for ratio％and SUVmean were calculated to represent structural and functional changes in AD patients,and the correlation between these 2 Z-scores was assessed.Results Correlations were found between ratio％and SUVmean,also between Z-scores of these two parameters in 29 brain regions(r=0.288 to 0.778,all P＜0.05).Among them 7 brain regions,i.e.bilateral middle temporal gyrus,right fusiform gyrus,right hippocampus,right precuneus,left lingual gyrus and right parahippocampal gyrus exhibited correlation coefficients greater than 0.6.Conclusion There were some relationships between brain structural and metabolic functions and their changes in AD patients showed on FDG PET/MR.

Objective To investigate correlations of the ratio of specific brain region volume to total brain volume(ratio％),standard uptake value(SUV)of specific brain region based on 18F-FDG PET/MR examination in Alzheimer disease(AD)patients,as well as the relationship between changes of these two.Methods Fifty AD patients were retrospectively collected.Based on FDG PET/MR,the ratio％and the mean SUV(SUVmean)of 40 specific brain regions were obtained,and the correlation between ratio％and SUVmean for each region were evaluated.According to a database of normal brains,Z-scores for ratio％and SUVmean were calculated to represent structural and functional changes in AD patients,and the correlation between these 2 Z-scores was assessed.Results Correlations were found between ratio％and SUVmean,also between Z-scores of these two parameters in 29 brain regions(r=0.288 to 0.778,all P＜0.05).Among them 7 brain regions,i.e.bilateral middle temporal gyrus,right fusiform gyrus,right hippocampus,right precuneus,left lingual gyrus and right parahippocampal gyrus exhibited correlation coefficients greater than 0.6.Conclusion There were some relationships between brain structural and metabolic functions and their changes in AD patients showed on FDG PET/MR.

Objective:To explore the influencing factors of clinical pregnancy rate after single cleavage embryo transfer.Methods:A total of 2 764 patients who underwent single cleavage embryo transfer in the Reproductive Medicine Center of Henan Provincial People's Hospital from January 2017 to October 2021 were included in a retrospective cohort study, The clinical data and cycle outcomes were analyzed by using univariate and multivariate logistic regression to explore the independent influencing factors of clinical pregnancy.Results:Multivariate logistic regression analysis showed that age, ovulation stimulation protocol, antral follicle number, blastomere number, fragment ratio, endometrial thickness, elective single embryo transfer were independent influencing factors of clinical pregnancy rate (all P<0.05). The effect of blastomere number on clinical pregnancy rate ( OR=2.92, 95% CI: 1.58-5.39) was stronger than that of fragment ratio ( OR=0.73, 95% CI: 0.55-0.98). The results of further stratified analysis showed that when the number of embryo cells was 8, the clinical pregnancy rate of patients less than 35 years old was significantly increased regardless of whether the embryo fragment ratio was more than 10% or not ( OR=4.78, 95% CI: 3.06-7.47; OR=3.53, 95% CI: 1.85-6.76), while in patients ≥35 years old, when the fragment ratio of transferred embryos was less than 10%, the clinical pregnancy rate of 8-cell embryos was significantly higher than that of 4-6-cell embryos ( OR=3.58, 95% CI: 1.64-7.84). Conclusion:The blastomere number and fragment ratio are the main influencing factors of the clinical pregnancy rate of single cleavage embryo transfer in young patients and the former has a stronger correlation with the clinical pregnancy rate. The decrease of blastomere number of transferred embryos is related to the decrease of clinical pregnancy rate. Cleavage embryos with 8 cells and fragment ratio less than 10% should be preferred for transfer.

Objective:To explore the influencing factors of clinical pregnancy rate after single cleavage embryo transfer.Methods:A total of 2 764 patients who underwent single cleavage embryo transfer in the Reproductive Medicine Center of Henan Provincial People's Hospital from January 2017 to October 2021 were included in a retrospective cohort study, The clinical data and cycle outcomes were analyzed by using univariate and multivariate logistic regression to explore the independent influencing factors of clinical pregnancy.Results:Multivariate logistic regression analysis showed that age, ovulation stimulation protocol, antral follicle number, blastomere number, fragment ratio, endometrial thickness, elective single embryo transfer were independent influencing factors of clinical pregnancy rate (all P<0.05). The effect of blastomere number on clinical pregnancy rate ( OR=2.92, 95% CI: 1.58-5.39) was stronger than that of fragment ratio ( OR=0.73, 95% CI: 0.55-0.98). The results of further stratified analysis showed that when the number of embryo cells was 8, the clinical pregnancy rate of patients less than 35 years old was significantly increased regardless of whether the embryo fragment ratio was more than 10% or not ( OR=4.78, 95% CI: 3.06-7.47; OR=3.53, 95% CI: 1.85-6.76), while in patients ≥35 years old, when the fragment ratio of transferred embryos was less than 10%, the clinical pregnancy rate of 8-cell embryos was significantly higher than that of 4-6-cell embryos ( OR=3.58, 95% CI: 1.64-7.84). Conclusion:The blastomere number and fragment ratio are the main influencing factors of the clinical pregnancy rate of single cleavage embryo transfer in young patients and the former has a stronger correlation with the clinical pregnancy rate. The decrease of blastomere number of transferred embryos is related to the decrease of clinical pregnancy rate. Cleavage embryos with 8 cells and fragment ratio less than 10% should be preferred for transfer.

【Objective】 To establish the donor bank for local region and distinguish the donors based on the past blood donation frequency and blood donation type, so as to improve the application efficiency of platelet bank. 【Methods】 1) According to the donation type and frequency of blood donors, the blood donors who had joined China Marrow Donor Program(CMDP)in our center from 2011 to 2020 were screened and classified. They are classified as reserve donors, prospective donors, and active donors. The donors, who met the selection conditions of active donors, were enrolled from all apheresis donors in 2020 to expand the local platelet bank. 2) In 2020, 739 blood donors who met the conditions of active donors were screened(including donors who had entered CMDP), and their HLA-A/B loci were detected by HLA high-resolution genotyping, and HPA was detected by Q-PCR genotyping. 3) The compatible platelets provided by three types of donors in 2021 were calculated. 【Results】 1) Taiyuan platelet bank, composed of donors with different previous donation experiences, had been constructed, including 739 active donors, 3840 prospective donors and 18 715 reserve donors. The composition ratio of ABO blood groups among three types of donors was found to be similar via chi square test; there were more male than female in three groups. 2) In 2021, the ratio of the average redonation by active donors in the platelet bank to the regular donation by the general donors was 14.4∶3.98. 3) Of the 142 compatible platelets, supplied to PTR patients in 2021, 83.8% of them came from the redonation of active donors after registration in the bank, and 9.9% and 6.3% from prospective donors and reserve donors, respectively. 4) In 2021, 28.1% of the stored pheresis platalets in our center had HLA typing data, and 54.2% of compatible platelets were retrieved from the inventory, which timely met the needs of clinical patients. 【Conclusion】 Integrating resources and distinguishing the activity degree of donors in platelet bank can reduce the cost of bank building and improve the application efficiency of the platelet bank.

【Objective】 To analyze the epidemic of hepatitis C virus (HCV) in voluntary blood donors , and to assess the residual risk of HCV transmission by blood transfusion in Taiyuan. 【Methods】 The HCV screening results of voluntary blood donors in Taiyuan from 2016 to 2021 were collected by blood center information system, and the epidemiologic feature of first-time and repeated donors were analyzed. The incidence-window period model was used to assess the residual risk of HCV transmission by transfusion in first-time/repeated donors as well as that in repeated donors under different blood screening modes. 【Results】 Of the 662 705 samples in Taiyuan from 2016 to 2021, the HCV positive rate of the first-time donors was 1.83‰(595/325 009) and the residual risk of HCV transmission was 14.91/100 000. The HCV positive rate of the repeated donors was 0.04‰ (13/337 696) and the residual risk was 0.31/1 000 000. The total residual risk of HCV transmission was 7.47/1 000 000. A total of 337 696 blood samples of repeated blood donors were tested, the repeated blood donors’ residual risk of transfusion-transmitted HCV was 0.31/100 000 after dual ELISA tests , and 0.06/100 000 after dual ELISA and once NAT, which reduce by 80.65% since NAT were adopted. 【Conclusion】 The residual risk of HCV transmission from repeated donors was less than that from first-time donors. The blood screening mode of HCV by dual ELISA and once NAT can effectively reduce the residual risk of transfusion-transmitted HCV and improve blood safety. The rate of repeat blood donation needs to be increased by continuously optimizing the recruitment strategy of blood donors.

【Objective】 To investigate the risk factors of vasovagal reactions(VVR) related to plasma donation, so as to put forward clinical suggestions for early identification and accurate intervention of high-risk groups to ensure the safety of plasma donation. 【Methods】 The demographic characteristics(i.e. gender, age, weight) and records of plasma donors(donation history, pulse before plasma donation, duration of collection, etc.) were collected from July to December 2019 in a region of Sichuan. Based on logistic regression analysis, the correlation between these factors and the risk of VVR was explored. 【Results】 The information of 69 172 donors was collected, and the incidence of VVR was 7.04‰. The risk of VVR was reduced by 99% in the group with plasma collection duration less than 30 minutes compared with the group with plasma collection duration more than 50 minutes(OR, 0.01; 95% CI, 0.00~0.01; P<0.001). The risk of male group was 94 % lower than that of female group(OR, 0.06; 95% CI, 0.04~0.10; P<0.001). Compared with the 45~50 kg group, the risk of weight greater than 80 kg group decreased by 80%(OR, 0.20; 95% CI, 0.09~0.42; P<0.001). The risk of repeated donation group was 34 % lower than that of the first time donation group(OR, 0.66; 95% CI, 0.47~0.91; P<0.001). The risk of VVR in the group with pulse greater than 90 bpm before plasma donation was 2.43 times that in the 60~69 bmp group(OR, 2.43; 95% CI, 1.75~3.36; P<0.001). 【Conclusion】 Duration of plasma collection, gender, weight, frequency of plasma donation, pulse before plasma donation and donor status are independent risk factors for plasma donation-related VVR. Among them, plasma collection duration, gender and weight were the main independent risk factors for plasma donation-related VVR. For donors with plasma collection duration more than 50 minutes, female and low weight, higher risk of VVR was presented and more preventive intervention should be given.

Donation related vasovagal reaction(DRVR) is the most common adverse reaction during blood donation. It is very important for blood banks to identify, treat and prevent DRVR accurately. At present, it is generally believed that psychological factors are the first major inducement of DRVR. Applied muscle tension (AMT) and salt supplementation have been proved to be effective interventions for vasovagal response; the identification methods of high-risk groups such as State Trait Anxiety Inventory, Medical Fear Inventory and Blood Donor Response Scale have been relatively mature, but the utilization rate is relatively low in China. In this paper, the main clinical manifestations, pathogenesis, research methods, related factors, management and prevention measures of DRVR, as well as the identification of high-risk groups before blood donation are reviewed.