Objective To investigate the therapeutic effects of Modified Baihu Decoction for sepsis-associated encephalopathy(SAE)patients with qi deficiency and toxin stagnation syndrome.Methods A randomized controlled trial was conducted in 72 SAE patients diagnosed with qi deficiency and toxin stagnation syndrome admitted to the Intensive Care Unit of Guangzhou Hospital of Intergrated Traditonal and West Medicine(affiliated to Guangzhou University of Chinese Medicine)between March 2024 and February 2025.Patients were randomly assigned to treatment group(n=36)and control group(n=36)using a random number table.The control group received conventional western therapy,while the treatment group additionally received Modified Baihu Decoction for 5 days.Changes in traditional Chinese medicine(TCM)syndrome scores,Glasgow Coma Scale(GCS)scores,and serum levels of procalcitonin(PCT),interleukin-6(IL-6),and N-terminal pro-brain natriuretic peptide(NT-proBNP)were observed.Improvement in consciousness and TCM syndrome efficacy were evaluated.Results(1)During the treatment period,6 patients from each group dropped out.A total of 60 patients were ultimately included in the statistical analysis,with 30 patients in each group.(2)After 5 days of treatment,the total effective rate for improving consciousness was 80.00％(24/30)in the treatment group and 63.33％(19/30)in the control group.Intergroup comparison(by chi-square test)showed that the consciousness improvement efficacy was significantly superior in the treatment group compared to the control group(P＜0.05).(3)After 5 days of treatment,the total effective rate for improving TCM syndrome was 60.00％(18/30)in the treatment group and 26.67％(8/30)in the control group.Intergroup comparison(by chi-square test)demonstrated significantly superior TCM syndrome improvement in the treatment group(P＜0.05).(4)After treatment,serum levels of PCT,IL-6,and NT-proBNP significantly decreased in both groups compared to baseline levels(P＜0.05 or P＜0.01).The treatment group showed significantly greater reductions in serum PCT,IL-6,and NT-proBNP levels than the control group(P＜0.05 or P＜0.01).(5)After treatment,GCS scores increased significantly from baseline levels in both groups(P＜0.05 or P＜0.01),while TCM syndrome scores significantly decreased(P＜0.05 or P＜0.01).The treatment group demonstrated significantly greater improvement in GCS score elevation and TCM syndrome score reduction than the control group(P＜0.01).Conclusion Modified Baihu Decoction effectively reduces inflammatory response and improves consciousness and TCM clinical symptoms in SAE patients with qi deficiency and toxin stagnation syndrome.

AIM: In this study, we assessed the safety and efficacy of generic and branded atorvastatin in patients with ischemic stroke/transient ischemic attack in real-world practice. METHODS: Patients admitted for ischemic stroke/transient ischemic attack between January 1, 2018 and March 31, 2021 who continually received atorvastatin for ≥6 months after diagnosis were included. Safety and efficacy endpoints in patients receiving the generic atorvastatin were compared with those of patients receiving the branded medication. Propensity score matching was applied to control con-founders. RESULTS: There were 665 patients in our final analysis, 302 in the branded group and 363 in the generic group. After propensity score matching, patients who received generic atorvastatin did not show a greater incidence of Ischemic Stroke/transient ischemic attack recurrence or onset of coronary heart disease. Similar changes in NIHSS and mRS scores were observed between the generic and branded groups. Consistent results were found in rates of hepatobiliary laboratory abnormalities and the compound adverse event profile of an elevated creatine kinase level, elevated aspartate aminotransferase/alanine aminotransferase levels, and intracranial hemorrhage. Results were consistent before and after propensity score matching. CONCLUSION: Both generic and branded atorvastatin are equally effective in preventing stroke recurrence and improving neurological deficits in patients with ischemic stroke/ transient ischemic attack. Both treatments are generally well tolerated by patients.

[ Objective ] To explore the relationship between outpatients amount and climate in Guangzhou City. [Methods] Correlation regression analysis of the relationship between monthly outpatients amount and simultaneous meteorological indexes was carried out in various departments of three hospitals of Guangzhou from the year of 1993 to 2001. [Results] The main meteorological factors affecting monthly outpatients amount are: monthly average atmospheric pressure, monthly lowest temperature, monthly sunshine hours, monthly rainfall, monthly relative humidity and monthly average wind speed. Monthly average atmospheric pressure, monthly lowest temperature, monthly relative humidity and monthly average wind speed are negatively correlated with monthly outpatients amount while monthly sunshine hours and monthly rainfall are positively correlated. Then the corresponding multivariate linear regression equations are established. The results of analysis showed that the main meteorological indexes which were related to the occurrence of diseases are the above six. [Conclusion] The corresponding multivariate linear regression equations can be used to forecast the epidemic trend of diseases in an area and this will provide evidences for the forecast of occurrence and prevalence of diseases.