Objective: To explore the relationship between beverage dependence and sleep quality among college students, providing empirical evidence for improving their sleep quality. Methods: From December 2024 to January 2025, a convenience sampling method was used to conduct a questionnaire survey among 3 974 college students from four universities in Anhui Province. The Beverage Addiction Scale for College Students (BASCS) was used to assess beverage dependence, and the Self rating Scale of Sleep(SRSS) was used to evaluate sleep quality. A multivariate Logistic regression model was employed to analyze the relationship between beverage dependence and sleep quality, and a restricted cubic spline model was used to examine the dose response relationship between the two. Results: The positive rate of beverage dependence symptoms among college students was 7.6%, with positive rates of 9.6%, 13.8%, and 7.4% for the withdrawal symptoms, health effects, and dependence symptoms dimensions, respectively. The detection rate of sleep disorders was 23.6%. Multivariate Logistic regression analysis showed that after adjusting for covariates such as grade, gender, and body mass index, compared with the no beverage dependence group, students with positive beverage dependence symptoms had a higher risk of sleep disorders( OR =3.71, 95% CI =2.87-4.80, P <0.01). The OR (95% CI ) for sleep disorders among students with positive symptoms in the withdrawal symptoms, health effects, and dependence symptoms dimensions were 2.80(2.22-3.53), 2.38(1.95-2.91), and 2.45(1.89-3.18)(all P <0.01). Further analysis using a restricted cubic spline model revealed that the overall beverage dependence score and its three dimensional scores were approximately linearly related to the risk of sleep disorders among college students (all nonlinear P >0.05). Conclusions Beverage dependence is associated with sleep quality among college students. Schools should take multiple approaches, such as health education on beverage awareness, to improve students sleep quality.

Objective To investigate the status quo of health management behaviors in elderly patients with type 2 diabetes mellitus(T2DM)complicating chronic complications and the influencing factors based on health ecology theory.Methods The convenience sampling method was used to select elderly patients with T2DM complicating chronic complications in the Shanghai City from January to July 2022 as the respondents.Based on the health ecology theory,the five aspects of personality traits,psychological and behavioral traits,family and community interpersonal networks,living and working conditions and policy environment were in-vestigated.The Pearson correlation coefficient was used to analyze the correlation of various variables.The hi-erarchical linear regression was used to analyze the influencing factors of health management behaviors in eld-erly patients with T2DM complicating chronic complications.Results A total of 272 questionnaires were dis-tributed and 264 valid questionnaires were recovered,with an effective recovery rate of 97.06％(264/272).There were statistically significant differences in DSMB-Oscores among the patients with different chronic complications number,sleep quality,per capita monthly household income and medical payment methods(P＜0.05).The DSMB-Oscore in elderly patients with T2DM complicating chronic complications was positively correlated with HLSCP,DES,PACIC and CIRS scores(P＜0.05),and negatively correlated with the PAID-5 score(P＜0.05).Conclusion The health management behaviors of elderly patients with T2DM complicating chronic complications is jointly affected and acted by many factors,and it is necessary to identify and manage the related influencing factors from different aspects and different levels.

Objective:To explore the role of diffusion tensor imaging (DTI) in monitoring prognosis after contralateral C7 nerve transfer in patients with central paralysis.Methods:The clinical data of a 56-year-old male patient with right limb motor impairment after cerebral infarction, admitted to the Department of Neurosurgery at Brain Hospital of Hunan Province in October 2023, were retrospectively analyzed. The patient had experienced right limb motor dysfunction for over 2 years following a cerebral infarction and was treated with contralateral C7 nerve transfer. Follow-ups were conducted at 2 and 6 months postoperatively. Motor function was assessed using the Fugl-Meyer Assessment (FMA) and Activities of Daily Living (ADL) scale, while changes in fractional anisotropy (FA) in the lesion area and corticospinal tract were monitored via DTI.Results:Postoperative follow-up of patient showed: (1) Significant improvement in motor function: ADL scores increased from 65 preoperatively to 75 (2 months postop) and 80 (6 months postop); FMA scores increased from 46 to 58 (2 months postop) and 61 (6 months postop). Muscle tension in the affected upper limb decreased markedly, and range of motion in the right shoulder joint improved. (2) Imaging improvements: DTI revealed an increase in FA values from 0.157 to 0.174 in the lesion area and from 0.52 to 0.53 in the corticospinal tract, indicating partial restoration of neural tract integrity.Conclusions:Contralateral C7 nerve transfer can effectively improve motor function in stroke patients. DTI technology provides an objective imaging basis for clinically assessing functional recovery by quantitatively evaluating changes in neural tract integrity, demonstrating significant value in guiding rehabilitation.

Objective:To explore the role of diffusion tensor imaging (DTI) in monitoring prognosis after contralateral C7 nerve transfer in patients with central paralysis.Methods:The clinical data of a 56-year-old male patient with right limb motor impairment after cerebral infarction, admitted to the Department of Neurosurgery at Brain Hospital of Hunan Province in October 2023, were retrospectively analyzed. The patient had experienced right limb motor dysfunction for over 2 years following a cerebral infarction and was treated with contralateral C7 nerve transfer. Follow-ups were conducted at 2 and 6 months postoperatively. Motor function was assessed using the Fugl-Meyer Assessment (FMA) and Activities of Daily Living (ADL) scale, while changes in fractional anisotropy (FA) in the lesion area and corticospinal tract were monitored via DTI.Results:Postoperative follow-up of patient showed: (1) Significant improvement in motor function: ADL scores increased from 65 preoperatively to 75 (2 months postop) and 80 (6 months postop); FMA scores increased from 46 to 58 (2 months postop) and 61 (6 months postop). Muscle tension in the affected upper limb decreased markedly, and range of motion in the right shoulder joint improved. (2) Imaging improvements: DTI revealed an increase in FA values from 0.157 to 0.174 in the lesion area and from 0.52 to 0.53 in the corticospinal tract, indicating partial restoration of neural tract integrity.Conclusions:Contralateral C7 nerve transfer can effectively improve motor function in stroke patients. DTI technology provides an objective imaging basis for clinically assessing functional recovery by quantitatively evaluating changes in neural tract integrity, demonstrating significant value in guiding rehabilitation.

Zinc is an important regulator of various biological processes such as protein synthesis,cell proliferation,migration and autophagy.The zinc transporter ZIP13(SLC39A13)is a homodimeric metal transporter functioning in transport of zinc,iron,and calcium plasma in body.ZIP13 is involved in disease by regulating zinc homeostasis,such as the key role of ZIP13 in connective tissue development because it is involved in the BMP/TGF-β signaling pathway.ZIP13 promotes the metastasis of human ovarian cancer cells by activating the Src/FAK signaling pathway and ZIP13 inhibits the biogenesis and energy expenditure of beige adipocytes by regulating C/EBP-β expression.

Objective:To analyze and evaluate the oral diseases burden in China from 1990 to 2021,and provide references on oral health policies making and adjustment. Methods:Using the Global Burden of Disease Study 2021 (GBD 2021) results,it described the trend of Disability Adjusted Life Years (DALYs) and DALYs rates from 1990 to 2021,analyzed the population and disease distribution and made an international comparisons. Results:From 1990 to 2021,the DALYs increased from 2.355 million person-years to 4.4001 million person-years,and the DALYs rate increased from 188.20 person-years/105 to 309.27 person-years/105. In terms of population distribution,the DALYs of oral diseases in females (2.3548 million person-years) were higher than that in males (2.0453 million person-years) in 2021,and the burden was clustered in middle-aged and elderly people. In terms of disease composition,the proportion of edentulism was more than 40％. In terms of international comparison,the DALYs accounted for 18.95％ of the world,and ranked first. The DALYs rate is in the middle,far lower than that of developed countries. Conclusion:From 1990 to 2021,the burden of oral diseases was on the rise,which was heavier than that in other countries. Moreover,there were differences between population and diseases. Attention should be paid to preventing and reducing the risk of disease and actively carry out treatment.

Objective:To analyze and evaluate the oral diseases burden in China from 1990 to 2021,and provide references on oral health policies making and adjustment. Methods:Using the Global Burden of Disease Study 2021 (GBD 2021) results,it described the trend of Disability Adjusted Life Years (DALYs) and DALYs rates from 1990 to 2021,analyzed the population and disease distribution and made an international comparisons. Results:From 1990 to 2021,the DALYs increased from 2.355 million person-years to 4.4001 million person-years,and the DALYs rate increased from 188.20 person-years/105 to 309.27 person-years/105. In terms of population distribution,the DALYs of oral diseases in females (2.3548 million person-years) were higher than that in males (2.0453 million person-years) in 2021,and the burden was clustered in middle-aged and elderly people. In terms of disease composition,the proportion of edentulism was more than 40％. In terms of international comparison,the DALYs accounted for 18.95％ of the world,and ranked first. The DALYs rate is in the middle,far lower than that of developed countries. Conclusion:From 1990 to 2021,the burden of oral diseases was on the rise,which was heavier than that in other countries. Moreover,there were differences between population and diseases. Attention should be paid to preventing and reducing the risk of disease and actively carry out treatment.

Objective:To explore the pathway of influencing factors of self-management in elderly patients with type 2 diabetes mellitus (T2DM) based on health belief theory.Methods:It was a cross-sectional study. A total of 210 elderly patients with T2DM admitted to Shanghai 10th People′s Hospital from January 2021 to March 2022 were selected as research subjects.The surveys of general data questionnaire, social support rating scale, the diabetes self-management scale, the health literacy survey scale for patients with chronic diseases, and the self-efficacy scale for patients with diabetes were conducted in all the subjects. The t test and Spearman correlation analysis were used to test the correlation among variables. Results:Social support, health literacy and self-efficacy were positively correlated with self-management scores in these patients ( r=0.380, 0.392, 0.274, all P<0.001). Univariate analysis showed that there were statistically significant differences in self-management among patients with different age, education level, physical exercise, medical payment method, family history and sleep quality (all P<0.05). Path analysis showed that the mediating effect of social support in the relationship between health literacy and self-efficacy was significant (95% CI: 0.014-0.117), social support, self-efficacy and health literacy directly affected self-management( β=0.25, 0.27, 0.35, all P<0.01). Self-efficacy and health literacy also positively affected self-management through multiple mediators of social support ( β=0.16, 0.27, both P<0.01). Conclusion:Social support, self-efficacy and health literacy mediate in the self-management of elderly patients with T2DM complicated with chronic complications and interact with each other.

Although deep learning plays an important role in cell nucleus segmentation, it still faces problems such as difficulty in extracting subtle features and blurring of nucleus edges in pathological diagnosis. Aiming at the above problems, a nuclear segmentation network combined with attention mechanism is proposed. The network uses UNet network as the basic structure and the depth separable residual (DSRC) module as the feature encoding to avoid losing the boundary information of the cell nucleus. The feature decoding uses the coordinate attention (CA) to enhance the long-range distance in the feature space and highlights the key information of the nuclear position. Finally, the semantics information fusion (SIF) module integrates the feature of deep and shallow layers to improve the segmentation effect. The experiments were performed on the 2018 data science bowl (DSB2018) dataset and the triple negative breast cancer (TNBC) dataset. For the two datasets, the accuracy of the proposed method was 92.01% and 89.80%, the sensitivity was 90.09% and 91.10%, and the mean intersection over union was 89.01% and 89.12%, respectively. The experimental results show that the proposed method can effectively segment the subtle regions of the nucleus, improve the segmentation accuracy, and provide a reliable basis for clinical diagnosis.
Cell Nucleus/pathology* ; Image Processing, Computer-Assisted/methods*

Objective:To explore the effects of "rain classroom" wisdom teaching on geriatric students′ autonomous learning ability and self-efficacy.Methods:From June to August, 2021, 61 nursing students who practiced in the department of gerontology of the Second Xiangya Hospital, Central South University were selected as research subjects, and divided into experimental group (30 students) and control group (31 students) by random number table method. In the experimental group, wisdom teaching based on "Rain classroom" was carried out at the same time as conventional teaching, while in the control group, conventional teaching was carried out, and the teaching effect was evaluated by the independent learning ability measurement scale and academic self-efficacy scale of nursing students.Results:The score of autonomous learning ability of nursing students in the experimental group was 68.55 ± 11.06, and that in the control group was 74.29 ± 9.16. The difference between the two groups was statistically significant ( t = -2.01, P<0.05). The academic self-efficacy scores of nursing students in experimental group and control group were 52.27 ± 11.56 and 52.64 ± 9.28 respectively. There was no significant difference between the two groups ( P>0.05). Conclusions:The wisdom teaching of "rain classroom" improves the independent learning ability of geriatric nursing students, and attaches importance to the cultivation of self-efficacy of nursing students, and the improvement of self-efficacy needs further research.