Objective:The research aims to determine the potential mediating role of psychological insecurity based on the correlation between death anxiety and obsessive-compulsive symptoms in college students during the pandemic of Covid-19 pandemic. The effects of negative coping styles were also investigated.Methods:The objective was achieved using a convenient sampling method. There were a total of 523 participants including 368 girls and 155 boys, aged 16-30 (19.93±2.19) years from Renmin University of China. Participants completed online the Chinese Version Templer Death Anxiety Scale, Self-Rating Feeling of Insecurity Scale, Symptom Checklist-90-Obsessive Compulsive and Simplified Coping Style Questionnaire. Mediational analysis with multiple regression was conducted to reveal the potential roles of psychological insecurity as a mediation factor. Negative coping style was used as a moderator between death anxiety and obsessive-compulsive symptoms, and a simple slope was used to further analysis.Results:Pearson correlation analysis showed that there were significant correlations between death anxiety, obsessive-compulsive symptoms, psychological insecurity, and negative coping style ( r=0.12-0.40, P<0. 01). Death anxiety was positively related to obsessive-compulsive symptoms (β=0.30, t=7.09, P<0.01).This correlation remained significant when psychological insecurity was introduced as a mediating factor (β=0.22, t=5.33, P<0.01). Negative coping style could moderate the relationship of death anxiety and obsessive-compulsive symptoms. Simple slope analysis showed that a higher tendency of negative coping style was associated with the enhanced impact of death anxiety on obsessive-compulsive symptoms (simple slope=0.27, P<0.01 and simple slope=0.08, P=0.17) for high negative coping style individuals and low-score ones, respectively. Conclusions:This research revealed that death anxiety could trigger obsessive-compulsive symptoms by increasing psychological insecurity; overall, higher levels of negative coping styles reinforce the relationship between death anxiety and obsessive-compulsive symptoms.

Objective:The research aims to determine the potential mediating role of psychological insecurity based on the correlation between death anxiety and obsessive-compulsive symptoms in college students during the pandemic of Covid-19 pandemic. The effects of negative coping styles were also investigated.Methods:The objective was achieved using a convenient sampling method. There were a total of 523 participants including 368 girls and 155 boys, aged 16-30 (19.93±2.19) years from Renmin University of China. Participants completed online the Chinese Version Templer Death Anxiety Scale, Self-Rating Feeling of Insecurity Scale, Symptom Checklist-90-Obsessive Compulsive and Simplified Coping Style Questionnaire. Mediational analysis with multiple regression was conducted to reveal the potential roles of psychological insecurity as a mediation factor. Negative coping style was used as a moderator between death anxiety and obsessive-compulsive symptoms, and a simple slope was used to further analysis.Results:Pearson correlation analysis showed that there were significant correlations between death anxiety, obsessive-compulsive symptoms, psychological insecurity, and negative coping style ( r=0.12-0.40, P<0. 01). Death anxiety was positively related to obsessive-compulsive symptoms (β=0.30, t=7.09, P<0.01).This correlation remained significant when psychological insecurity was introduced as a mediating factor (β=0.22, t=5.33, P<0.01). Negative coping style could moderate the relationship of death anxiety and obsessive-compulsive symptoms. Simple slope analysis showed that a higher tendency of negative coping style was associated with the enhanced impact of death anxiety on obsessive-compulsive symptoms (simple slope=0.27, P<0.01 and simple slope=0.08, P=0.17) for high negative coping style individuals and low-score ones, respectively. Conclusions:This research revealed that death anxiety could trigger obsessive-compulsive symptoms by increasing psychological insecurity; overall, higher levels of negative coping styles reinforce the relationship between death anxiety and obsessive-compulsive symptoms.

Objective To investigate the clinical and pathological characteristics, diagnosis and differential diagnosis of uterine intravenous leiomyoma (IVL) , so as to improve the detection of the disease.Methods Five cases of IVL were retrospected, who were treated and diagnosed by clinical gross examination,morphologic features and immunohistochemical staining in Tumor Hospital of Anyang from 2011 to 2015.Results Symptoms of IVL were usually nonspecific, most patients experienced hypermenorrhea, abdominal pain or distension, and pelvic mass.Typical pathological changes were intravenous visible grey weblike or worm-formed nodules, which could be pulled out.Microscopically, the tumors were composed of mild spindle-shaped cells with rare mitotic figure and closely related to blood vessels.The tumors were positive for smooth muscle derived marker, progesterone receptor, estrogen receptor, and negative for S-100, HMB45 and CD34.However CD34 can displayed vascular endothelial cells around the tumor.Conclusion Uterine IVL is a benign tumor with malignant biological behavior, which has different clinical pathological features of leiomyoma ordinary.Surgery is the main treatment method.A satisfactory therapeutic effect can be achieved by selecting the appropriate extent of surgery.Long term follow up of iVL patients after operation is important.

Objective To investigate the histological changes of normal human skin after fixed irradiation with multiple-pulse fractional Er:YAG laser.Methods After hair removal,the upper arms of 7 healthy volunteers were consecutively irradiated with multiple-pulse fractional Er:YAG laser.Tissue samples were resected from the irradiated skin at 1,24,48,72 hours,on day 5,7,15,and 30 after the irradiation.Hematoxylin and eosin(HE)staining and Masson staining were performed to observe the histological changes and collagen proliferation respectively.Immunohistochemical staining was used to detect the expression of heat shock protein(HSP)70 and 47.Results The consecutive irradiation with multi-pulse fractional Er:YAG laser generated an array of tapering microscopic treatment zones(MTZs)of gasification and ablation in the upper arm skin.After the irradiation,inflammation developed in the microscopic lesions with the epithelization of epidermal cells within 7 days; local dermal collagen was renewed and remodelled during the 7th to 30th day.HSP70 expression peaked as early as 48 hours after the treatment and maintained until the 7th day,while the high expression of HSP47 persisted from the 15th to 30th day after irradiation.Conclusion The fixed,multiplepulse and fractional Er:YAG laser irradiation can reach the deep dermis,and induce the local proliferation of dermal collagen.

Object To study the change of serum soluble interleukin 2 receptor(SIL-2R) in syphilitic patients and its clinical significance.Methods The serum SIL-2R level in syphilitic patients of different stages and after therapy were detected using the ELISA technique.Results The serum SIL-2R level in syphiliti patients was higher than that in control group(P0 05).Conclusions SIL-2R level and its variation have some reference value for evaluating the therapeutic effect and judgement of the disease course in syphilitic patients.