OBJECTIVE: To evaluate the prevalence and one-year prognosis associated with frailty in a contemporary cohort of older patients with non-ST-elevation acute coronary syndrome (NSTEACS). METHODS: The IMPACT-TIMING-GO registry (IMPACT of Time of Intervention in patients with Myocardial Infarction with Non-ST seGment elevation. ManaGement and Outcomes) prospectively included 1020 patients with NSTEACS undergoing invasive coronary angiography between April and May 2021. For this sub-study, patients ≥ 65 years were selected. Frailty was assessed according to FRAIL scale. We studied all-cause mortality and the composite of all-cause mortality or all-cause hospitalizations at one-year follow-up after discharge. RESULTS: Five hundred and sixty seven patients (mean age: 75.8 ± 6.7 years, 28.2% women) were included: 316 (55.7%) were robust, 183 (32.3%) prefrail, and 68 (12.0%) frail. Frail patients were significantly older, more often women, and presented a worse baseline clinical profile. There were no differences among groups regarding pretreatment with a P2Y12 inhibitor. An urgent angiography (< 24 h) was less frequently performed in frail patients, with no differences regarding revascularization approach or in main in-hospital adverse events, although acute kidney disease occurred more frequently in frail patients. At 1-year follow-up, 20 patients died (3.6%). Chronic kidney disease was independently associated with 1-year all-cause death, although a trend towards higher mortality was observed in frail patients (HR = 3.01; 95% CI: 0.93-9.78; P = 0.065). Frailty was independently associated with higher 1-year all-cause mortality or all-cause rehospitalizations (HR = 2.23; 95% CI: 1.43-3.46; P < 0.001). CONCLUSIONS In older patients with NSTEACS, frailty independently associates higher all-cause mortality or all-cause hospital admissions at one-year follow-up.

Objectives: To report the clinical and functional outcomes of patients undergoing total temporomandibular joint (TMJ) replacement with customized prostheses. Materials and Methods: Six female patients treated between 2018 and 2024 for advanced TMJ pathology—severe osteoarthritis (n=5) or condylar osteochondroma (n=1)—were included. All underwent unilateral total joint replacement using customized prostheses planned with cone-beam computed tomography and magnetic resonance imaging. Interincisal mouth opening (IMO), pain (visual analog scale), jaw function (JF), and dietary intake (DI), assessed through a Likert-type psychometric scale, were recorded preoperatively and during a minimum follow-up of 24 months. Results: All patients showed postoperative improvement. Median JF decreased from 6.5 to 3.5, DI from 8 to 1.5, and pain from 7 to 2. Postoperative IMO averaged 32 to 33 mm. One patient required revision for screw displacement without long-term functional compromise. Conclusion Customized TMJ prostheses proved safe and effective, demonstrating consistent improvements in pain, mandibular function, and dietary capacity in patients with severe joint disease. This approach represents a reliable therapeutic option when combined with individualized surgical planning.

Although its use in daily practice is not common, optical coherence tomography (OCT) is a powerful research tool in invasive cardiology. This report describes a hazy angiography image after percutaneous coronary intervention that has been assessed using OCT. Based on the results of the OCT, the patient underwent an elective coronary angioplasty with standard anticoagulation. After implantation of the stent, an intracoronary hazy image was seen on angiography. The use of OCT permitted a correct diagnosis and a successful treatment. This paper provides a discussion of the advantages and disadvantages of OCT, and a comparison with intravascular ultrasound.
Angiography ; Angioplasty ; Cardiac Catheterization ; Cardiology ; Humans ; Percutaneous Coronary Intervention ; Stents ; Thrombosis ; Tomography, Optical Coherence ; Ultrasonography, Interventional