We observed 285 cases of culture proved shigellosis from Jan. 1978 to July 1981 at W.M.B.H. in Busan. We specially observed the clinical and bacteriological response to Oxolinic acid in 59 cases from Jan. to July 1981. The following results were obtained. 1. The most commonly isolated shigella strains was Sh. flexneri (85.3%) followed by Sh. sonnei (7.4%), Sh. boydii (4.2%) and Sh. dysenteriae(3.2%). 2. Antibiotic sensitivity test revealed that more than 90% of strains were resistant to Tetracycline, Chloramphenicol and Ampicillin. Resistance strains to Gentamycin and Oxocid were found in less than 12.2% and 14.3% respectively. 3. The multiple antibiotic resistant strains were observed in about 80% of 59 strains, which were resistant to 3~5 antibiotics. The most of these strains were resistant to Ampicillin, Chloramphenicol and Tetracycline. In 3 cases it was resistant to all kinds of antibiotics but oxolinic acid. 4. Oxolinic acid showed growth-inhibitory zone of more than 11 mm with the concentration of 2mcg/ml in 95% and M.I.C. value of less than 0.76mcg/ml in 90%. 5. After administration of Oxolinic acid, there was clinical response within 2 days in 76.5% and conversion to negative stool culture within 2days in 68.8%. 6. Compared with placebo group, there was parallel clinical and bacteriologic effectiveness between Oxolinic acid and Rifampin.
Ampicillin ; Anti-Bacterial Agents ; Asthma* ; Busan ; Chloramphenicol ; Dermatitis, Atopic* ; Dysentery, Bacillary ; Gentamicins ; Oxolinic Acid ; Rifampin ; Shigella ; Tetracycline

We observed 285 cases of culture proved shigellosis from Jan. 1978 to July 1981 at W.M.B.H. in Busan. We specially observed the clinical and bacteriological response to Oxolinic acid in 59 cases from Jan. to July 1981. The following results were obtained. 1. The most commonly isolated shigella strains was Sh. flexneri (85.3%) followed by Sh. sonnei (7.4%), Sh. boydii (4.2%) and Sh. dysenteriae(3.2%). 2. Antibiotic sensitivity test revealed that more than 90% of strains were resistant to Tetracycline, Chloramphenicol and Ampicillin. Resistance strains to Gentamycin and Oxocid were found in less than 12.2% and 14.3% respectively. 3. The multiple antibiotic resistant strains were observed in about 80% of 59 strains, which were resistant to 3~5 antibiotics. The most of these strains were resistant to Ampicillin, Chloramphenicol and Tetracycline. In 3 cases it was resistant to all kinds of antibiotics but oxolinic acid. 4. Oxolinic acid showed growth-inhibitory zone of more than 11 mm with the concentration of 2mcg/ml in 95% and M.I.C. value of less than 0.76mcg/ml in 90%. 5. After administration of Oxolinic acid, there was clinical response within 2 days in 76.5% and conversion to negative stool culture within 2days in 68.8%. 6. Compared with placebo group, there was parallel clinical and bacteriologic effectiveness between Oxolinic acid and Rifampin.
Ampicillin ; Anti-Bacterial Agents ; Asthma* ; Busan ; Chloramphenicol ; Dermatitis, Atopic* ; Dysentery, Bacillary ; Gentamicins ; Oxolinic Acid ; Rifampin ; Shigella ; Tetracycline

Clinical and bacteriological studies were made on 168 cases of culture proved childhood shigellosis at Wallace Memorial Baptist Hospital in Busan between Aug. 1978 and July 1980. The following results were obtained. 1. Of 168 cases, 99 cases were male and 69 were female, the ratio being 1.4:1. The most frequently affected age group was between one three six years(57.7%) and the youngest was one month old infant(2 cases). 2. The peak incidence was in summer (34.5%), however it occurred throughout the year, even in winter(17.3%). 3. The most frequent symptoms on admission were diarrhea (86.9%), fever(77.4%), vomithing (36.9%), convulsion(38.7%) and abdominal pain(28.6%). 4. WBC count in peripheral blood was variable from leukocytosis to leukopenia and over 5% of band form was seen in 52.4%. 5. Sh. Flexneri was the most frequently isolated strain(86.3%) followed by Sh. Sonnei(6.5%), Sh. Boydii(4.8%) and Sh. Dysenteriae (2.4%). 6. The result of sensitivity test reveales that Oxolinic acid was the most sensitive drug(86.2%) followed by Gentamicin(83.9%) and Cefazolin(80.4%). It also revealed the high prevalence of resistance to Ampicillin(88.0%), Chloramphenicol(92.7%) and Tetracycline (95.6%). 7. 54 isolated shigellae strains were tested for Minimal Inhibitory Concentration in tube dilution method and inhibition zone diameter in single disc test (Rifampin disc 5g/ml). MIC were below 12.5g/ml in 77.7% and below 25g/ml in 90.7% and inhibition zone diameter was over 8mm in 88.7%. 8. Clinical response to antibiotic therapy revealed that clinical improvement was seen within 5 days of therapy in 48.1% of Ampicillin therapy group and 58.1% of Septrin therapy group and within 4 days of therapy in 95.7% of initial Rifampin therapy group and 97.2% of altrnative Rifampin therapy group. 9. Bacteriological response to antibiotic therapy revealed that within 4 days of Ampicillin and Septrin therapy the negative conversion rate was 49.1% and 54.4% respectively. The negative conversion within 3days of Rifampin therapy was observed in 93.4% of initial therapy group and 96.6% of alternative therapy group. 10. There was no untoward reaction of Rifampin during therapy except for the reddish discoloration of urine and stool.
Ampicillin ; Busan ; Diarrhea ; Dysentery, Bacillary* ; Female ; Humans ; Incidence ; Leukocytosis ; Leukopenia ; Male ; Oxolinic Acid ; Prevalence ; Protestantism ; Rifampin* ; Shigella ; Tetracycline ; Trimethoprim, Sulfamethoxazole Drug Combination

Oxolinic acid is a weak-organic acid which developed recently from Nalidixic acid. Author reports a clinical observation about the effect of oxolinic acid on patients of genito-urinary tract infection, who visited to our O.P.D. from May 1976 to Nov. 1976. Daily dose is 1.5gm per oral for 5-28 days. 1. Among 12 cases of nongonococcal urethritis, excellent and good effects are obtained in 10 cases. 2. Among 9 cases of Gonococcal urethritis, excellent effects are resulted in 7 cases. 3. Among 6 cases of acute cystitis, excellent in 4 cases and good result in 2 cases are noted. 4. Among 5 cases of chronic prostatitis, only 1 case excellent and good effects are noted in 2 cases. 5. Among 3 cases of epididymitis, good effects are seen in 2 cases. 6. On 2 cases of chronic cystitis, 1 case is excellent and no effect in 1 case is noted. 7. On 1 case of pyelonephritis, no effect is obtained. 8. Oxolinic acid has the antibacterial activity in 11 cases of 17 cases staphylococcus & streptococcus infections, 7 cases of 9 cases gonococcus infections, and 1 case of 2 cases proteus infections. No significant toxicity is seen through the course of therapy.
Cystitis ; Epididymitis ; Humans ; Male ; Nalidixic Acid ; Neisseria gonorrhoeae ; Oxolinic Acid* ; Prostatitis ; Proteus Infections ; Pyelonephritis ; Staphylococcus ; Streptococcus ; Urethritis