Background: The patients’ view, perception, and evaluation of illness as an individual, as well as their emotional and behavioral responses, are among the criteria predicting the QoL. Increased illness perception and adjustment are emphasized to ensure patients to return to their active life after acute myocardial infarction (AMI) continue their lives more healthily, and have higher levels of physical, mental, and social well-being. Aim: This study aimed to evaluate the illness perception and quality of life of patients who had an AMI. Materials and Methods: This descriptive study included 100 patients diagnosed with AMI at the cardiology department of Third State Central Hospital and Second State Central Hospitals. The data were collected using Illness Perception Questionnaire-Revised and Myocardial Infarction Dimensional Assessment Scale. Result: The mean age of the patients with AMI was 52.2±12.01 years, and 51% were male. Among the subscales of the illness perception questionnaire, the highest mean score was observed for Illness Identity (13.99±5.01), while Treatment Control (19.10±3.18) had the lowest. The lowest score was for Illness Coherence (10.31±2.16). The overall Myocardial Infarction Dimensional Assessment Scale score (43.00±13.10) of the patients was observed to be moderate. The Illness Perception Questionnaire-Revised subdimensions were observed to have a positive and significant correlation with Myocardial Infarction Dimensional Assessment Scale total score and subscales mean scores. Regression analysis revealed that Illness Coherence and Emotional Representation were significant predictors of QOL. Patients scoring high in these areas reported better QOL. Patients with recurrent infarctions showed significantly lower scores in quality of life (t=-2.234, (p=0.029) and illness perception (t=-3.809, p=.001). Conclusion The study demonstrates that illness perception in AMI patients has a significant positive relationship with their quality of life. Specifically, understanding of the illness and emotional representation were key predictors of better quality of life. This suggests that nursing care and psychosocial support targeting patient understanding and emotional coping can play a crucial role in improving post-infarction quality of life.