1.Reconstruction of a partial maxillectomy defect using a pedicled buccal fat pad flap in an elderly oral squamous cell carcinoma patient
Soon-Young KANG ; Min-Hyung CHOI ; Seong-Gon KIM
Oral Biology Research 2026;50(1):2-
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity, with rising incidence among patients of advanced age. We present the case of a 90-year-old woman with OSCC of the left posterior maxilla, treated by mass excision followed by immediate reconstruction using a pedicled buccal fat pad (BFP) flap. The flap provided reliable coverage, demonstrated robust vascularity, and achieved complete epithelialization within 6 weeks. Postoperative healing was uneventful, with no evidence of infection, necrosis, or other complications. This case underscores that, even in patients of advanced age, surgical excision combined with BFP reconstruction—when guided by individualized clinical decision-making and consideration of significant geriatric constraints such as frailty and limited anesthetic tolerance—can yield predictable functional outcomes while minimizing operative time and morbidity.
2.Closed reduction of midline palatal fracture using a palatal acrylic splint and interdental wiring: case report
Jae-Seung JUNG ; Kyung-Heun SON ; Hyo-jun KIM ; Ji-Su OH ; Seong-Yong MOON
Oral Biology Research 2026;50(1):4-
Midline palatal fractures compromise maxillary transverse stability and cause oro-nasal communication. We report a successful minimally invasive reconstruction based on AO CMF principles. A 60-year-old male with Le Fort II and midline palatal fractures following a fall exhibited nasal regurgitation. Associated facial fractures were managed conservatively, while the palatal fracture was addressed with a customized acrylic splint fabricated via model-based virtual surgery to restore pre-traumatic occlusion.Intraoperatively, segments were repositioned through manual reduction, followed by intermolar wire ligation and splint fixation. Nasal regurgitation resolved by postoperative day 4. Evaluation at 10 days confirmed anatomical arch width restoration. Stable occlusion was maintained throughout the 6-week splinting period. Closed reduction using customized splints and interdental ligation is an effective, minimally invasive alternative for managing midline palatal fractures, particularly when open reduction is challenging.
3.Guided endodontic microsurgery using a simplified surgical guide for mandibular first molars with intact buccal cortical bone
Oral Biology Research 2026;50(1):3-
Endodontic microsurgery in mandibular molars is often challenging because of limited surgical access and the presence of thick buccal cortical bone. This case report presents two cases in which a simplified digital surgical guide was used to facilitate precise osteotomy and localization of the root apex in mandibular molars with intact buccal cortical bone. Both patients presented with symptomatic apical periodontitis associated with previously treated mandibular first molars. Radiographic and cone-beam computed tomography (CBCT) examinations identified periapical lesions involving the mesial roots, with intact buccal cortical plate. A surgical guide was digitally designed by integrating intraoral scan data with CBCT images using implant planning software and was fabricated via 3D printing. The guide enabled accurate determination of the initial osteotomy position. Guided osteotomy allowed precise localization of the root apex with minimal bone removal, and both cases demonstrated favorable clinical and radiographic healing during follow-up.
5.Integration of conventional and digital approach in full mouth rehabilitation of a patient with severe tooth wear
On-Yu CHEON ; Jeong-Woo YUN ; Su-Min KIM ; Yu-Ri HEO ; Mee-Kyoung SON
Oral Biology Research 2025;49(1):6-
This report presents the case of severe tooth wear and vertical dimension loss in a 71-year-old male patient. A combined conventional and digital approach was employed for full-mouth rehabilitation. After determining an increase in the vertical dimension of 5.5 mm using an anterior jig and diagnostic wax-up, provisional restorations were fabricated and adjusted throughout the adaptation period.For the fabrication of the final prosthesis, digital methodologies such as oral scanning and occlusal acquisition were performed. To obtain precise margin data, a die model was fabricated using the traditional impression method, followed by model scanning, which was then combined with intraoral scan data. The final prosthesis was made of zirconia to enhance esthetics and strength. Consequently, the treatment enhanced both function and esthetics, leading to high patient satisfaction with the outcomes.
6.Effect of masticatory positioning on long-term occlusal stability in patients who underwent full mouth rehabilitation: a 10-year follow-up
Heungku KWAK ; Eunsong KWAK ; Ayeon SOHN ; Gyeongje LEE ; Mee-Kyoung SON
Oral Biology Research 2025;49(1):5-
This study evaluated the long-term stability and efficacy of occlusion achieved by setting a normalized chewing position as the therapeutic position in patients with abnormal chewing positions due to tooth loss or malocclusion. Furthermore, the study monitored the recovery rate of the stomatognathic system. Sixteen patients undergoing oral functional rehabilitation participated in the study, utilizing an intraoral Gothic arch tracer to normalize abnormal chewing positions and designate the apex of the resultant chewing patterns as the therapeutic position. The first set of data was gathered during occlusal reconstruction at the point when a therapeutic position was necessary, and the second set was collected approximately 10 years later under the same conditions. Four mandibular movements—chewing movements for hard food (CM-H), chewing movements for soft food (CM-S), border movement (BM), and maximum intercuspation position (MICP)—were compared to assess the long-term stability between the chewing position and occlusion and the recovery rate of the stomatognathic system. The findings showed a 63% concordance between CM-H and MICP, confirming the long-term stability of both the chewing position and occlusion. Furthermore, the concordance between CM-H and CM-S increased by 13%, whereas the alignment between the chewing position and BM increased by 25%. In summary, the concordance across all four movements improved by 19%, demonstrating increased long-term recovery rate of the stomatognathic system. These findings provide clinical evidence that occlusal reconstruction centered on the chewing position offers long-term stability and recovery. By establishing an efficient occlusion that harmonized with the chewing patterns, this approach compensates for age-related declines in chewing function and helps maintain the stomatognathic system health.
7.Custom surgical guide for orthognathic surgery
Oral Biology Research 2025;49(1):1-
The present narrative review thoroughly investigates recent publications on custom surgical guides for orthognathic surgery, focusing on the evaluating their advancements, efficacy, and precision, particularly in terms of enhancing the surgical outcomes. Key areas, such as technical limitations, patient-specific challenges, and cost and accessibility issues, are explored. A significant finding is the scarcity of studies employing robust statistical methods, making many conclusions preliminary and underscoring the need for more rigorous research studies. Future studies should aim to provide a comprehensive, statistically validated assessment of the role and impact of custom surgical guides in orthognathic surgery. While this review highlights their potential, it also identifies critical gaps in the existing literature.
8.Diagnostic challenges of glandular odontogenic cyst:two cases initially confused with radicular cysts
Minsung KIM ; Suk-Ja YOON ; Jaeseo LEE
Oral Biology Research 2025;49(1):7-
A glandular odontogenic cyst (GOC) is a rare type of odontogenic cyst characterized by a broad clinical and pathological spectrum, overlapping with different lesions ranging from lateral periodontal cysts to low-grade mucoepidermoid carcinoma. Further, including GOC in the initial diagnosis is frequently challenging due to its nonspecific radiological results. Despite its rarity, accurate GOC diagnosis is crucial due to its aggressive nature and high recurrence potential. Therefore, various GOC cases need to be presented to clinicians. This study aims to report the clinical and radiological characteristics of two cases of GOCs that were initially misdiagnosed as radicular cysts.
9.Effect of the vertical implant position relative to the adjacent cementoenamel junction on peri-implantation bone loss
Yeon-Joo HA ; Jae-Mok LEE ; Yong-Gun KIM ; Sung-Min HWANG
Oral Biology Research 2025;49(1):4-
Vertical positioning of dental implants relative to the cementoenamel junction (CEJ) of the adjacent teeth is essential for maintaining peri-implant bone stability and long-term success. This retrospective study evaluated how the vertical distance from the CEJ affects peri-implant bone loss in patients who had implants positioned at various distances from the CEJ. Bone loss was evaluated using panoramic radiographs over a 2-year follow-up period, with additional consideration of factors such as smoking and diabetes. Implants positioned >4 mm away from the CEJ exhibited a higher mean bone loss; however, this difference was not significant. Smoking significantly influenced bone loss, whereas diabetes and jaw location had no significant effect. These results highlight the potential influence of vertical implant positioning on peri-implant bone health and highlight the importance of appropriate maintenance care to reduce bone loss and ensure long-term implant survival.
10.Fibroblast growth factor-2 with a xenogenic bone substitute in the treatment of class III furcation in dogs
Xing-Hui PIAO ; Young-Joon KIM ; Jun-Young CHA ; Eui-Ri NA ; Jeong-In CHOI
Oral Biology Research 2025;49(1):3-
Achieving periodontal regeneration in class III furcation defects is challenging. Many studies have applied growth factors to periodontal defects, including fibroblast growth factors (FGFs), which demonstrate angiogenic activity and mitogenic ability. This study aimed to evaluate periodontal regeneration following the application of FGF-2 to deproteinized bovine bone mineral (DBBM) in surgically created supra-alveolar class III furcation defects of the mandibular premolars of beagles. The defects were divided into the control, DBBM, and FGF/DBBM groups. For the control group, only root planing was performed. For the DBBM group, only DBBM particles were implanted into the furcation. For the FGF/DBBM group, DBBM was soaked with 0.3% FGF-2 solution, and FGF-2/ DBBM was then positioned into the furcation. After 8 weeks, the dogs were euthanized. The micro-computed tomography analysis revealed that the changes in the bone volume of the furcation area were significantly greater in the FGF/DBBM group than in the DBBM group. In the histomorphometric analysis, the area of the newly formed bone was significantly greater in the FGF/DBBM group than in the DBBM or control group. The cementum extension was significantly longer in the FGF/DBBM or DBBM group than in the control group. The epithelial area was significantly less in the FGF/DBBM group than in the DBBM or control group. The application of FGF combined with DBBM to a class III defect enhanced the regeneration of periodontal tissues and increased the healing rate. This finding indicates that FGF-2 combined with DBBM can be applied to class III defects clinically.

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