1.Severe Hypertriglyceridemia-Induced Acute Pancreatitis in Pregnancy: A Case Report and Review of Management
Shaleela Mohd Esha ; Chua Yi Jiang ; Wong Hui Chin ; Ooi Xin Yi ; Yong Sy Liang
Journal of the ASEAN Federation of Endocrine Societies 2026;41(S1):65-
Introduction:
Severe hypertriglyceridemia during pregnancy is a rare
yet potentially life-threatening disorder. It is frequently
linked to acute pancreatitis and poses considerable risks
for both maternal and fetal morbidity.
Case:
We report a 35-year-old G4P3 female at 33 + 6 weeks
gestation with underlying type 2 diabetes mellitus who
presented with acute abdominal pain, nausea, vomiting,
and poor oral intake, initially mistaken for preterm labor
and sepsis. Further evaluation revealed profound hypertriglyceridemia (triglycerides 79.1 mmol/L) with markedly
elevated total cholesterol (>32 mmol/L) and raised serum
amylase, consistent with hypertriglyceridemia-induced
acute pancreatitis. She was managed in a multidisciplinary
setting with intravenous insulin infusion, dextrose supplementation, aggressive fluid resuscitation, and empiric
antibiotics. Due to clinical deterioration and ongoing risk of
maternal complications, she underwent emergency lower
segment caesarean section and exploratory laparotomy
at 34 weeks of gestation. Intraoperative findings included
inflammatory intra-abdominal fluid and a bulky pancreas,
supporting the diagnosis. Rapid biochemical improvement was observed following treatment, with triglyceride levels
decreasing by approximately 70% within 24 hours (79.1–
24.0 mmol/L) and achieving >90% reduction over 10 days.
Postpartum management included initiation of omega-3
fatty acids, fibrate, and statin therapy, resulting in sustained
lipid control. Ophthalmologic examination demonstrated
lipemia retinalis, further confirming severe dyslipidemia.
Conclusion
This case highlights the importance of early recognition of
severe hypertriglyceridemia in pregnancy, particularly in
patients with metabolic risk factors such as diabetes. Prompt
initiation of insulin therapy can achieve rapid triglyceride
reduction and may obviate the need for plasmapheresis in
selected cases. Delivery should be considered in the setting
of maternal instability. Long-term lipid management
postpartum is essential for preventing recurrence and
reducing future metabolic risk. A multidisciplinary
approach remains critical in optimizing both maternal and
fetal outcomes in this rare but serious condition.
Female
;
Pregnancy
;
Acute Disease
;
Pancreatitis
2.Validation of a Food Choice Questionnaire among Adolescents in Penang, Malaysia
Ooi SY ; Mohd Nash MT ; Barakai-un Nisak MY ; Chin YS
Malaysian Journal of Nutrition 2015;21(1):25-35
Introduction: This is a validation study of the modified version of the Food Choice Questionnaire (FCQ), a multidimensional measure of food choice motives.
Methods: Adolescents aged 15 to 17 years attending schools from three randomly selected co-educational and multiracial public secondary schools were invited to participate in this study. Data were collected using a sell-administered modified version of the FCQ consisting of 58 items assessing 13 factors including health, mood, convenience, sensory appeal, natural content, price, weight control, familiarity, ethical concern, religion, parents, peers and media. Factor analysis with the extraction of a maximum likelihood and varimax rotation were performed to validate the FCQ.
Results: A total of 306 students comprising 64.7% Malay, 19.3% Chinese and 16.0% Indian with a mean age of 16.1±0.3 years participated in this study. Based on their BMI status, a majority (71.9%) of the participants had normal weight, 8.2% were thin, 1.6% severely thin while 12.1% were overweight and 6.2% obese. Six factors (health and nutrition knowledge, price and convenience, media, mood and sensory appeal, peers, and parents), consisting of 36 items and explaining 45.9% of the variance, remained from the factor analysis. The reliability of the FCQ factors was good, with Cronbach's a coefficient values as follows: health and nutrition knowledge=0.84, price and convenience=0.82, media=0.89, mood and sensory appeal=0.79, peers=0.84, and parents=0.75.
Conclusion: This modified version of the FCQ validated among Malaysian adolescents is recommended for future research determining food choice motives of adolescents.


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