Background: Over the past decade, silver nanoparticles (AgNPs) have gained considerable attention in biomedical research due to their unique physicochemical properties and intrinsic biological activity. Their nanoscale dimensions, high surface-to-volume ratio, and tunable surface chemistry make them promising candidates for advanced drug delivery applications. AgNP-based systems provide a versatile platform for controlled and site-specific drug release, thereby enhancing therapeutic efficacy while minimizing systemic side effects. This review article summarizes the properties of zeolites enhanced with silver nanoparticles (AgNPs). Drug delivery systems incorporating AgNPs operate through both passive and active targeting mechanisms to transport therapeutic agents, including antibiotics, anti-inflammatory drugs, and anticancer compounds, to specific tissues or pathological sites. The performance of these systems is largely governed by the physicochemical characteristics of AgNPs, such as particle size, morphology, surface charge, stability, and surface functionalization. Surface modification enables improved biocompatibility, enhanced drug loading capacity, and controlled release kinetics. Furthermore, the inherent antibacterial activity of AgNPs contributes synergistically to therapeutic outcomes, particularly in the treatment of infected wounds and biofilm-associated infections. Materials and Methods: This review article was prepared by selecting and analyzing relevant publications indexed in Scopus and Web of Science published between 2005 and 2025, focusing on characteristics of AgNPs, drug delivery systems based on zeolites modified with AgNPs and their applications. Conclusion Silver nanoparticle-based drug delivery systems represent an advanced and multifunctional therapeutic platform. Their capacity for targeted, sustained, and controlled drug release, combined with intrinsic antimicrobial activity, offers significant advantages over conventional delivery systems. These properties position AgNPs as promising materials for the development of next-generation biomedical and pharmaceutical applications.

Background: Onion peel is a raw material rich in biologically active compounds; however, within the framework of food waste management in Mongolia, detailed studies and safety evaluations of this material remain insufficient. Therefore, it is necessary to scientifically determine the properties of onion peel waste generated from the food production sector and explore its potential for reuse. Aim: To evaluate the safety parameters of red and white onion (Allium cepa L.) peels generated during food processing and to determine their bioactive compound content and antioxidant activity. Materials and Methods: Red and white onion peels were used in this study. Safety parameters were determined using atomic absorption spectrometry (for heavy metals) and GC-MS/MS and LC-MS/MS (for pesticide residues). The raw materials were extracted with 70% ethanol, and dry extracts were obtained using a vacuum evaporator and freeze dryer. Total phenolic content (TPC) and total flavonoid content (TFC) were measured by spectrophotometric methods, while antioxidant activity was evaluated using the DPPH radical scavenging assay. Results: The analysis showed that the levels of lead, cadmium, and 205 pesticide residues in onion peels did not exceed the permissible limits, indicating that the material is safe. Phytochemical analysis revealed the presence of quercetin and luteolin derivatives in the dry extracts. The TPC (27.40±1.64%) and TFC (17.95±1.47%) of red onion peel extract were significantly higher than those of white onion peel extract (20.34±0.34% and 12.69±1.44%, respectively). The IC₅₀ values were 17.58 μg·mL⁻¹ for red onion and 19.41 μg·mL⁻¹ for white onion, indicating strong antioxidant activity for natural composite extracts. Conclusion Onion peel waste meets safety requirements and exhibits strong antioxidant activity. These findings demonstrate its potential as a valuable raw material for the development of antioxidant preparations and functional food additives aimed at preventing oxidative stress.

Background: In recent years, natural compounds have been shown to play an important role in cancer prevention and early-stage therapy. Flavanones, a class of polyphenolic compounds present in plants, vegetables, seeds, fruit peels, and flowers, have been identified to possess anticancer, antioxidant, anti-inflammatory, and antibacterial bioactivities. Cancer has become a major global economic and public health challenge. According to international statistics, one in four individuals (22.8%) die from non-communicable diseases, while one in six (16.8%) die from cancer. Aim: To investigate the effect of a flavanone (5,2’,3’-trihydroxy-6,7-methylenedioxyflavanone) isolated from Iris tenuifolia on the migration of liver cancer cells. Materials and Methods: The study was conducted at the Institute of Biomedicine, Mongolian National University of Medical Sciences. The effect of the flavanone (5,2’,3’-trihydroxy-6,7-methylenedioxyflavanone) on cancer cell migration was evaluated in vitro using the scratch assay. Human liver cancer cells (HepG2) were revived and stabilized before experiments were performed. Results: HepG2 cells were treated with a 2.5 μg/mL concentration of the flavanone for 24 hours. In the control group, an initial scratch width of 0.9 mm was reduced to 0.65 mm after 24 hours due to cell proliferation and migration into the denuded area. However, treatment with the 2.5 μg/mL flavanone concentration resulted in the complete inhibition of cell migration. Conclusion The flavanone isolated from Iris tenuifolia effectively suppresses the migration of liver cancer cells.

Background: In recent years, natural compounds have been shown to play an important role in cancer prevention and early-stage therapy. Flavanones, a class of polyphenolic compounds present in plants, vegetables, seeds, fruit peels, and flowers, have been identified to possess anticancer, antioxidant, anti-inflammatory, and antibacterial bioactivities. Cancer has become a major global economic and public health challenge. According to international statistics, one in four individuals (22.8%) die from non-communicable diseases, while one in six (16.8%) die from cancer. Aim: To investigate the effect of flavanone (5,2’,3’-trihydroxy-6,7-methylenedioxyflavanone) isolated from Iris tenuifolia on the migration of lung cancer cells. Materials and Methods: The study was conducted at the Institute of Biomedicine, MNUMS. The effect of flavanone (5,2’,3’-trihydroxy-6,7-methylenedioxyflavanone) on cancer cell migration was evaluated in vitro using the scratch assay. Human lung cancer cells (A549) were revived and stabilized before experiments were performed. Results: We treated A549 cancer cells with different concentrations of flavanone (1.25 μg/ml, 2.5 μg/ml) for 24 hours and analyzed them using the scratch assay. A cell-free gap of 0.9 mm in width was created, and after 24 hours, A549 cells migrated and proliferated into the gap, reducing its width to 0.25 mm. Treatment with 2.5 μg/ml flavanone completely inhibited cell migration. Conclusion Flavanone isolated from Iris tenuifolia inhibits lung cancer cell migration in a doseand time-dependent manner.

Background: In recent years, scientists have found that certain natural compounds have significant potential in cancer prevention and early-stage cancer treatment. Flavanones, a class of polyphenolic compounds found in plants, vegetables, seeds, fruit peels, and flowers, have been identified to possess anticancer, antioxidant, anti- inflammatory, and antibacterial bioactivities. Cancer has become a major global challenge in terms of both economic and public health concerns. Global statistics indicate that 22.8% of deaths are attributed to non-communicable diseases, and 16.8% are caused by cancer, accounting for one in four and one in six deaths, respectively. Aim : To investigate anticancer effects of Iris Tenuifolia-derived flavanone on cancer cell lines. Materials and Methods : The study was conducted at the Bio-Medical Research Institute of the Mongolian National Uni versity of Medical Sciences, investigating the effect of flavanones on cancer cell viability under in vitro conditions using the MTT assay. In the study, colon, liver, and lung cancer cells were cultured, stabilized, and used for the experiments. Colorectal cancer cells (MC38), liver cancer cells (HepG2), and lung cancer cells (A549) were revived, cultured, and stabilized for use in the experimental procedures. Statistical analysis of the results was performed using Microsoft Excel 2010, and graphs were generated using GraphPad Prism 8. Differences between groups were analyzed using Student’s t-test, and a p-value of <0.05 was considered statistically significant. Results : We treated MC38, HepG2, and A549 cancer cells with different concentrations of flavanone (2.5 µM, 5 µM, and 10 µM) for 24 to 48 hours to evaluate cell viability. Flavanone inhibited A549 cell viability by 2.5 μM-10%, 5 μM-25%, and 10 μM-38%, respectively. For HepG2 cells, flavanone treatment at concentrations of 5-10 µM reduced cell viability by 28–58%. No statistically significant effect on the viability of MC38 cells was observed following treatment with flavanone at concentrations ranging from 2.5 to 10 µM. Additionally, although MC38 inhibited cell viability in a dose-de pendent manner in cell cultures, it had a statistically significant effect at higher concentrations of 30-200 μM (p<0.01). Conclusion Flavanone inhibits the cancer cell viability in a dose and time dependent manner