Background: High-dose chemotherapy followed by autologous stem cell transplantation (HDC-ASCT) as a consolidation treatment is a promising approach for eligible patients with newly diagnosed primary central nervous system lymphoma (PCNSL). Methods: In this retrospective analysis, 22 patients with newly diagnosed PCNSL received chemotherapy with rituximab, methotrexate, procarbazine, and vincristine. Those who showed complete or partial response subsequently received consolidation HDC-ASCT with a thiotepa-based conditioning regimen but did not undergo radiotherapy. Results: The PCNSL patients had a median age of 57 years (range, 49‒67 yr); of the total patients, 9.1% had a performance status of 2 or higher, and 72.1% had multiple lesions.Approximately 82% of patients received six cycles of induction chemotherapy, which was well tolerated with excellent disease control. The rate of confirmed or unconfirmed complete response increased from 45.5% at the period of interim analysis to 81.8% prior to the initiation of HDC-ASCT. With a median follow-up of 19.6 months (range, 7.5‒56.5 mo), the 2-year progression-free survival and overall survival estimates were 84% and 88%, respectively. No treatment-related deaths occurred. Grade 3 toxicity was recorded in 90.9% of the patients after undergoing the HDC-ASCT, and the most common grade 3 adverse event was febrile neutropenia without sepsis. Conclusion The discussed treatment approach is feasible in patients with newly diagnosed PCNSL, yielding encouraging results.

PURPOSE: The purpose of this research was to develop and evaluate the effect of a mind map for relief of emotional labor and burnout among nurses in outpatient departments in cancer hospitals. METHODS: We developed a mind map to reduce emotional labor and burnout. A quasi-experimental study was used with a nonequivalent control group pretest-posttest design. Data were collected from December 2012 to April 2013. Participants were 35 nurses working in the outpatient department of a cancer hospital. The experimental group participated in the mind map program biweekly for 10 weeks. Data were analyzed using chi2-test, Mann-Whitney U test, paired t-test, and Wilcoxon sign rank test with the SPSS 21.0 program. RESULTS: The physical burnout and total burnout scores decreased significantly in the intervention group which took the mind map program. CONCLUSION: Findings indicate that the mind map is an effective intervention to reduce burnout in outpatient department nurses.
Cancer Care Facilities* ; Humans ; Outpatients*

Meningeal melanocytoma is a rare benign tumor with relatively good prognosis. However, local aggressive behavior of meningeal melanocytoma has been reported, especially in cases of incomplete surgical resection. Malignant transformation was raised as possible cause by prior reports to explain this phenomenon. We present an unusual case of meningeal melanocytoma associated with histologically benign leptomeningeal spread and its subsequent aggressive clinical course, and describe its radiological findings.
Adult ; Humans ; Magnetic Resonance Imaging ; Male ; Melanoma/*pathology/surgery ; Meningeal Neoplasms/*pathology/surgery ; Neoplasm Invasiveness/pathology ; Prognosis

Desmoplastic fibroma is a rare benign primary bone tumor that is histologically similar to the soft tissue desmoid tumor. It most often involves the mandible, large long bone or iliac bone. Desmoplastic fibroma in a toe has been extremely rarely reported. Authors report a rare case of desmoplastic fibroma of bone occurring in the distal phalanx of a foot, with descriptions of the radiographic and MRI findings, correlation of the radiologic and pathologic findings, and discussion on the differential diagnosis of the tumor.
Adolescent ; Bone Neoplasms/*diagnosis ; Diagnosis, Differential ; Female ; Fibroma, Desmoplastic/*diagnosis ; Humans ; Magnetic Resonance Imaging ; Male ; Toes/*pathology

OBJECTIVES: Psychiatric patients had less access to psychiatric care due to a stigma associated with psychiatric care. However there have been numerous efforts to break down the stigma. One of them was to change the name of the discipline to Mental Health Medicine, which was established nationwide in August, 2011. Authors try to understand the change of concepts by according to the change of the name of psychiatry. Subjects consisted of undergraduate and graduate students, and university faculty members. METHODS: The survey was conducted by the Kyung Hee University mass e-mail system. Mails were delivered to the undergraduate and graduate students, and university faculty members. The contents of the survey consisted of questions regarding awareness of the name change (psychiatry-->mental health medicine), positive or negative impressions of the name change, psychiatric history, and eligibility of access to the psychiatric clinic. RESULTS: Most respondents were not aware of the name change (90.8%), however they generally responded to the changed name positively (92.7%). Also they responded that by changing the name, the possibility of the easy access to psychiatric treatment would be expected. The undergraduate students group, the graduate students group, and the below 22 year old group responded more favorably to the name change compared to the faculty group and the above 22-year-old group. They also responded positively to the improvement of easy access to psychiatric treatment. However, regarding the effects of the name change on deciding to receive the psychiatric treatment, only small numbers were agreed to accept treatment. CONCLUSION: This survey showed that the less-than-22-year-old group, undergraduate students group, and graduate students group thought more positively to the name change (psychiatry->mental health medicine) compared to the group of more than the 22 years old and the faculty group. However, only small numbers of those groups answered that they can visit and receive psychiatric treatment when they are needed. One of the reasons they are reluctant to receive psychiatric care is due to the concern of the discrimination in employment and insurance coverage. Campaigns against stigmas for the psychiatric care via the proper method and time are needed nationwide, and should be enhanced. Practical policy should be re-established.
Surveys and Questionnaires ; Discrimination (Psychology) ; Electronic Mail ; Employment ; Humans ; Insurance Coverage ; Mental Health ; Postal Service ; Young Adult

BACKGROUND/AIMS: Rectal carcinoid tumors, at diagnosis, are as small as 10 mm or less in about 80% of patients. These tumors are generally removed by endoscopic resection. The aim of this study was to compare treatment efficacy and safety between endoscopic submucosal resection with band ligation (ESMR-L) and conventional polypectomy. METHODS: Between January 2005 and September 2010, a total of 88 patients, who visited at Busan Paik Hospital and Kosin University Gospel Hospital for endoscopic resection of rectal carcinoid, were reviewed, retrospectively. RESULTS: Thirty-three cases were treated by ESMR-L, and 55 cases by conventional polypectomy. There were no significant difference in the size of tumor between ESMR-L group and polypectomy group (6.02+/-2.36 vs. 6.49+/-3.24 mm, p=0.474). The rate of positive resection margin was significantly lower in ESMR-L group (2/33, 6.1%) than in polypectomy group (19/55, 34.5%; p=0.002). The rate of positive vertical resection margin, among others, was markedly lower in ESMR-L group (1/33, 3.0%) compared to polypectomy group (19/55, 34.5%; p<0.001). CONCLUSIONS: ESMR-L, rather than conventional polypectomy, is a useful treatment option for removal of rectal carcinoid tumors less than 10 mm in diameter.
Carcinoid Tumor ; Humans ; Ligation ; Treatment Outcome

Primary cardiac angiosarcoma is a very rare disease with a poor prognosis. We report a case of a patient with a primary cardiac angiosarcoma who presented with cardiac tamponade; the angiosarcoma was successfully resected surgically.
Cardiac Tamponade ; Heart Neoplasms ; Hemangiosarcoma ; Humans ; Pericardial Effusion ; Prognosis ; Rare Diseases

Spontaneous disappearance of breast calcification has rarely been reported. The majority of cases of spontaneously resolving calcifications have been concerned with benign processes. We report here on breast papillary carcinoma that showed spontaneously resolving microcalcifications without newly developed parenchymal changes on the follow-up mammogram.
Breast Neoplasms ; Breast* ; Carcinoma, Papillary* ; Follow-Up Studies

Hemangioma is the most common soft tissue tumor in the body. Though it may occur anywhere in the body, hemangioma of the uterus is a very rare tumor. Hemangioma is almost asymptomatic, but it is sometimes clinically important because it can cause massive hemorrhage and this is a life-threatening condition. We report here on the magnetic resonance imaging and pathologic findings of cavernous hemangioma of the uterus in a 32-year-woman with menorrhagia.
Female ; Hemangioma ; Hemangioma, Cavernous* ; Hemorrhage ; Magnetic Resonance Imaging* ; Menorrhagia ; Uterine Neoplasms ; Uterus*

PURPOSE: To assess the applicability of quantitative MR microscopy for the detection of glycosaminoglycan (GAG) depletion as an early sign of degeneration in the articular cartilage of humans treated by trypsin. MATERIALS AND METHODS: Four cartilage-bone blocks were obtained from the patient who had suffered from osteoarthritis of the knee and underwent a total knee replacement arthroscopy. Each articular cartilage segment was resected as to a round disk shape (8 mm in diameter) with a remnant of subchondral bone 1 mm in thickness. Four different culture solutions were prepared, and these solutions were 0.2 mg/ml of trypsin solution (group 1), 1 mM of Gd (DTPA) 2-mixed trypsin solution (group 2), phosphate buffered saline (PBS) (group 3), and 1 mM of Gd (DTPA) 2-mixed PBS (group 4). The cartilages were cultured and then MR imagings were performed every hour for 5 hrs, and we continued the additional cultures of 24 hrs, 36 hrs and 48 hrs. Three imaging sequences were used: T1-weighted spin echo (TR/TE, 450/22), proton density turbo spin echo with fat suppression (TR/TE, 3000/25), and CPMG (Carr-Purcell-Meiboom-Gill) (TR/TE/TI, 760/21-168, 360). MR imaging data were analyzed with pixel-by-pixel comparisons in all groups. RESULTS:The GAG loss in the articular cartilage was increased proportionately to the culture duration. Mean changes of T1 relaxation time were 1.2% for group 1, -1.9% for group 3, -54.7% for group 2 and -64.2% for group 4 (p<0.05). When comparing by linear profile on the T1-weighted images, SNR increased and T1 relaxation time decreased for group 2 and 4, as the culture duration increased (p<0.05). On the correlation analysis, there is significant correlation between GAG loss and Gd (DTPA) 2-enhancement for group 2 (p=0.0431), but there was no significant difference for group 4 (p=0.0918). More enhancement with Gd (DTPA) 2-was noted for group 2 than for group 4. Group 2 showed a diffuse enhancement in all the layers of cartilage, but for group 4, prominent enhancement was noted only in the superficial layer. CONCLUSION: Early degenerative changes of the articular cartilage were not noted on the T1-weighted images, turbo spin echo with fat suppresison and T1, T2, or the rho relaxometry by a 1.5 T machine. Only Gd (DTPA) 2- enhancement was useful in the detection of early degeneration of the articular cartilage.
Arthroplasty, Replacement, Knee ; Arthroscopy ; Cartilage ; Cartilage, Articular* ; Humans* ; Knee ; Magnetic Resonance Imaging* ; Microscopy ; Osteoarthritis ; Protons ; Relaxation ; Trypsin