Background: and Purpose To investigate the association between derivatives of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP) and the risk of stroke by subtype, and ischemic heart disease (IHD). Methods: We employed a case cohort design consisting of cardiovascular disease cases (n=1,521; stroke, n=1,271; IHD, n=265) and a random sub-cohort (n=4,761) in a large Japanese population-based study. d-ROMs and BAP were measured in plasma samples collected between 1995 and 1999. Hazard ratios (HRs) were estimated using weighted Cox proportional hazards methods according to d-ROMs and BAP quartiles, adjusted for age, sex, area, and potential confounding factors. Results: Analysis revealed a positive association between d-ROMs and the risk of total stroke, ischemic stroke, IHD, and the composite outcome of ischemic stroke and IHD. The multivariable HRs and 95% confidence intervals (CIs) for the highest versus lowest quartiles for d-ROMs were 1.34 (95% CI: 1.11–1.63) for total stroke (P for trend<0.001), 1.47 (1.16–1.86) for ischemic stroke (P for trend<0.001), 1.47 (1.02–2.11) for IHD (P for trend=0.072), 1.47 (0.87–2.49) for subarachnoid hemorrhage (P for trend=0.101), and 1.01 (0.72–1.41) for intraparenchymal hemorrhage (P for trend=0.618). In contrast, no significant association was detected between BAP levels and the risk of cardiovascular disease. Conclusions Analysis revealed that d-ROMs levels were positively associated with the risk of ischemic stroke and heart disease but not with hemorrhagic stroke.

BACKGROUND: Pneumonia is a major global public health concern. Taking antioxidant nutrients has attracted attention for their potential role in reducing pneumonia mortality. Although studies in Western countries have evaluated this association, the current evidence remains controversial, and research in Asia remains limited. This cohort study investigated the association between dietary antioxidant nutrients intake and pneumonia mortality in Japanese population. METHODS: Data were collected from the Japan Public Health Center-based Prospective Study between 1995 and 1998, with follow-up until the end of 2018. The intake of antioxidant nutrients was assessed using a validated food-frequency questionnaire. The Cox proportional hazard model was employed to calculate hazard ratios (HRs) and p-trends for pneumonia mortality, adjusting for potential confounding factors including age, area, body mass index, smoking status, alcohol intake, physical activity, postmenopausal status, occupation, coffee intake, green tea intake, antihypertensive medication use, vitamin-supplement use, and total energy intake. RESULTS: The analysis included data from 39,850 men and 46,705 women. Over a median follow-up of 20.8 years, 813 men and 477 women died from pneumonia. The multivariable model revealed that a higher intake of cryptoxanthin (p-trend = 0.027 in men; 0.019 in women), lycopene (p-trend = 0.016 in women), vitamin C (p-trend = 0.022 in men), and vitamin E (p-trend = 0.031 in women) was significantly associated with a reduction in pneumonia mortality. CONCLUSIONS Higher dietary intake of cryptonxanthin, lycopene, and vitamins C and E was associated with a low risk of pneumonia mortality in Japanese adults.
Humans ; Male ; Japan/epidemiology* ; Female ; Prospective Studies ; Middle Aged ; Pneumonia/mortality* ; Antioxidants/administration & dosage* ; Diet/statistics & numerical data* ; Aged ; Adult ; Nutrients ; East Asian People

BACKGROUND: The association between meat, fish, or fatty acid intake and acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) has been investigated in a few studies, and the results were inconsistent. In addition, most studies are mainly based on the United States and European countries, in which the dietary patterns differ from that in Asia. Therefore, the risk of AML/MDS from meat, fish, or fatty acid intake in Asia requires further exploration. The aim of this study was to investigate the association between AML/MDS incidence and meat, fish, or fatty acid intake using the Japan Public Health Center-based prospective study. METHODS: The present study included 93,366 participants who were eligible for analysis and followed up from the 5-year survey date until December 2012. We estimated the impact of their intake on AML/MDS incidence using a Cox proportional hazards model. RESULTS: The study participants were followed up for 1,345,002 person-years. During the follow-up period, we identified 67 AML and 49 MDS cases. An increased intake of processed red meat was significantly associated with the incidence of AML/MDS, with a hazard ratio of 1.63 (95% confidence interval, 1.03-2.57) for the highest versus lowest tertile and a P_trend of 0.04. Meanwhile, the intake of other foods and fatty acids was not associated with AML/MDS. CONCLUSION In this Japanese population, processed red meat was associated with an increased incidence of AML/MDS.
Animals ; Japan/epidemiology* ; Prospective Studies ; Incidence ; Public Health ; Meat/adverse effects* ; Fatty Acids/adverse effects* ; Leukemia, Myeloid, Acute ; Myelodysplastic Syndromes/epidemiology*