Objective ToinvestigatetheapplicationvalueofMSCTinthedifferentialdiagnosisofadvancedgastriccancerand gastriclymphoma.Methods AretrospectiveanalysisofCTimagingdatawascarriedoutin48patientswithadvancedgastriccancer and16patientswithgastriclymphoma,confirmedbypathology.ThedifferencesofCT manifestations,includingtumorsiteinthe stomach,gastricwallchanges,gastricmucosachanges,changesofgastriccavity,densityandtheenhancementpatterns,adjacentadiposetissue changes,otherorganinvolvementandlymphnodemetastasis,wereanalyzed.Results Foradvancedgastriccancer,thetumorswere locatedinthegastricantrumin21casesandinmultiplesitesin11cases.Forgastriclymphoma,thetumorswerelocatedinthegastric bodyin2casesandinmultiplesitesin10cases.Foradvancedgastriccancer,gastricmucosaldisruptionwasfoundin33cases,stenosisofthe gastriclumenin27cases,andinhomogeneousenhancementin36cases.Forgastriclymphoma,gastricmucosaldisruptionwasfound in2cases,stenosisofthegastriclumenin3cases,andinhomogeneousenhancementin2cases.Foradvancedgastriccancer,morethan twogroupsoflymphnodesaroundthestomachwereinvolvedin23cases,andretroperitoneallymphadenopathybelowthelevelofrenalhilumin 9cases.Forgastriclymphoma,morethantwogroupsoflymphnodesaroundthestomachwereinvolvedin8cases,andretroperitoneal lymphadenopathybelowthelevelofrenalhilumin4cases.TherewerestatisticallysignificantdifferencesinCTmanifestationsmentionedabove, notinotherCT manifestationsbetweenthetwogroups.Conclusion MSCTcanwelldemonstratethethicknessofthediseasedgastricwall,the lesion’sdensity,siteandextent,theinvolvementofadjacentorgans,andboththeabdominalandretroperitoneallymphadenopathy. MSCTfindingsofadvancedgastriccancerandgastriclymphomahavecertaindifferenceandtheirowncharacteristics,providingCT evidencesforthedifferentialdiagnosiswhichishelpfulforthediagnosisandtreatment.