Hybrid chest lesion is an uncommon congenital thoracic anomaly. We report a case of hybrid chest lesion in a neonate, who was initially treated for congenital pneumonia. The initial computed tomography thorax in portovenous phase was performed due to persistent opacities at right mid and lower zones on chest radiograph. The echocardiographic findings were suspicious of congenital cardiovascular anomalies. The subsequent ECG-gated CT angiography thorax demonstrated features consistent with hybrid lesion, together with its vascular anomalies which were confirmed intraoperatively and histologically. The baby underwent a successful surgery to resect the sequestrated lobe with plication of the right diaphragm and is doing well.